James L. Boyer
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View article: Conjugated bile acid-driven CD14+CD16+ monocyte infiltration promotes cholestatic liver injury by enhancing hepatocyte necroptosis
Conjugated bile acid-driven CD14+CD16+ monocyte infiltration promotes cholestatic liver injury by enhancing hepatocyte necroptosis Open
This study revealed that CD14+CD16+ monocyte-derived tumor necrosis factor-alpha (TNFα) and factor-related apoptosis ligand (FASL) drive hepatocyte necroptosis via the receptor-interacting serine/threonine-protein kin…
View article: PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress
PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress Open
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are characterized by the destruction of the small bile ducts and the formation of multifocal biliary strictures, respectively, impairing bile flow. This leads to th…
View article: Primary biliary cholangitis, a rising health burden
Primary biliary cholangitis, a rising health burden Open
Primary biliary cholangitis (PBC) is a rare immune-mediated disease, commonly affecting women in their 40s, and ultimately progressing to liver failure. The incidence and prevalence of the disease are increasing worldwide, possibly due to …
View article: PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases
PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases Open
Cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), result from an impairment of bile flow that leads to the hepatic retention of bile acids, causing liver injury. Until recentl…
View article: Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation
Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation Open
Background and Aims: Inflammatory response is crucial for bile acid (BA)-induced cholestatic liver injury, but molecular mechanisms remain to be elucidated. Solute Carrier Family 35 Member C1 (SLC35C1) can transport Guanosine diphosphate-f…
View article: Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease Open
Exploring the pathogenesis of and developing therapies for cholestatic liver diseases such as primary sclerosing cholangitis (PSC) remains challenging, partly due to a paucity of in vitro models that capture the complex environments contri…
View article: Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing Cholangitis
Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing Cholangitis Open
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease in which the bile ducts of the liver become inflamed and scarred. Scarred bile ducts eventually narrow and obstruct and can cause additional liver pathology includ…
View article: Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis Open
Cholangiocytes play a crucial role in bile formation. Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of PBC remains unclear despite being characterized as an autoimmune disease. …
View article: Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling
Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling Open
Background and Aims: Bile acids trigger a hepatic inflammatory response, causing cholestatic liver injury. Runt-related transcription factor-1 (RUNX1), primarily known as a master modulator in hematopoiesis, plays a pivotal role in mediati…
View article: Bile Acid Induced Inflammation and the Role of β-Catenin
Bile Acid Induced Inflammation and the Role of β-Catenin Open
View article: Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans Open
View article: SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface Open
Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces fatty acid (FA) oxidation. Here, we identified 17 individuals w…
View article: Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis Open
View article: Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis Open
View article: Effects of immunosuppressive drugs on COVID‐19 severity in patients with autoimmune hepatitis
Effects of immunosuppressive drugs on COVID‐19 severity in patients with autoimmune hepatitis Open
Background We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID‐19) in autoimmune hepatitis (AIH). Patients and methods Data of AIH patients with laboratory confirmed …
View article: A homozygous R148W mutation in <i>Semaphorin 7A</i> causes progressive familial intrahepatic cholestasis
A homozygous R148W mutation in <i>Semaphorin 7A</i> causes progressive familial intrahepatic cholestasis Open
View article: Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis
Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis Open
Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (…
View article: Paul David Berk, editor extraordinaire and bilirubinologist
Paul David Berk, editor extraordinaire and bilirubinologist Open
Paul D. Berk passed away on July 11, 2021 after a prolonged illness. The Hepatology Community mourns his loss. He was 83. Paul was born on April 3rd, 1938 in Brooklyn, N.Y. He showed an early interest in editing, serving as Editor-in- Chie…
View article: In Memoriam: Peter J. Meier (1947–2021)
In Memoriam: Peter J. Meier (1947–2021) Open
View article: Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids Open
View article: The role of bile acids in cholestatic liver injury
The role of bile acids in cholestatic liver injury Open
Clinical disorders that impair bile flow result in retention of bile acids and cholestatic liver injury, characterized by parenchymal cell death, bile duct proliferation, liver inflammation and fibrosis. However, the pathogenic role of bil…
View article: Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study
Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study Open
Background and Aims Data regarding outcome of COVID‐19 in patients with autoimmune hepatitis (AIH) are lacking. Approach and Results We performed a retrospective study on patients with AIH and COVID‐19 from 34 centers in Europe and the Ame…
View article: The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology Open
View article: Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR)
Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR) Open
View article: Arsenic (+ 3 Oxidation State) Methyltransferase and the Methylation of Arsenicals in the Invertebrate Chordate Ciona intestinalis
Arsenic (+ 3 Oxidation State) Methyltransferase and the Methylation of Arsenicals in the Invertebrate Chordate Ciona intestinalis Open
Biotransformation of inorganic arsenic (iAs) involves methylation catalyzed by arsenic (+ 3 oxidation state) methyltransferase (As3mt) yielding mono-, di-, and trimethylated arsenicals. To investigate the evolution of molecular mechanisms …
View article: Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis Open
View article: Co-culture of bile-derived organoids from primary sclerosing cholangitis patients with CD4+ T cells replicates pathogenic, CCL20 dependent biliary-immune interactions
Co-culture of bile-derived organoids from primary sclerosing cholangitis patients with CD4+ T cells replicates pathogenic, CCL20 dependent biliary-immune interactions Open
View article: Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol
Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol Open
Cholestatic liver diseases result in the hepatic retention of bile acids, causing subsequent liver toxicity. Peroxisome proliferator‐activated receptor alpha (PPARα) regulates bile acid metabolism. In this retrospective observational study…
View article: Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis Open
The inflammatory response plays an important role in cholestatic liver injury where bile acid (BA) induction of proinflammatory cytokines in hepatocytes is an initial pathophysiologic event. However, the signaling pathways involving BA sti…
View article: A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis Open