Explanipedia

Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers Open

Nabila Dahodwala, Theodore Kapogiannis, Amanda Cruz, James C. Beck, Thomas L. Davis , et al. · 2025

Background Real‐world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data. Objectives We sought to identify treatment patterns and t…

Improving Prediction of Falls and Cognitive Impairment in Parkinson Disease: Protocol for a Decentralized Observational Study Open

A HOYT, Casey Dorney, Peggy Auinger, Kathryn Murphy, Michelle Porto , et al. · 2025

Background Falls and cognitive impairment are major sources of disability in Parkinson disease (PD). The ability to accurately identify individuals with PD at high risk for falls and cognitive impairment would provide an opportunity for in…

The potential of distributed diagnostics for the early detection of Parkinson's disease Open

A. Jay Khanna, James C. Beck, Kathleen L. Poston, Michael A. Schwarzschild, Graham B. Jones · 2025

Parkinson's disease represents a major healthcare burden with over 1 million confirmed cases and economic costs of care exceeding $50 billion in the United States alone. A challenge in the evaluation of potentially disease delaying, preven…

The diverse effects of ketamine, jack-of-all-trades: a narrative review Open

Nicholas David Richards, Simon Howell, Michael Bellamy, James C. Beck · 2025

Participant-reported personal utility of genetic testing for Parkinson’s disease and interest in clinical trial participation Open

Hannah Oas, Lola Cook, Tae‐Hwi Schwantes‐An, Laurence E. Walsh, Anne‐Marie Wills , et al. · 2024

Parkinson’s disease variant detection and disclosure: PD GENEration, a North American study Open

Lola Cook, Jennifer Verbrugge, Tae‐Hwi Schwantes‐An, Jeanine Schulze, Tatiana Foroud , et al. · 2024

Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinson’s disease; however, individuals with Parkinson’s disease are often unaware of their genetic status…

Improving Parkinson's Disease Care through Systematic Screening for Depression Open

Connie Marras, Zachary Meyer, Hongliang Liu, Sheng Luo, Sneha Mantri , et al. · 2024

Background Depression is common in Parkinson's disease (PD) but is underrecognized clinically. Although systematic screening is a recommended strategy to improve depression recognition in primary care practice, it has not been widely used …

Participant-reported personal utility of genetic testing for Parkinson’s disease and interest in clinical trial participation Open

Jennifer Verbrugge, Hannah Oas, Lola Cook, Tae‐Hwi Schwantes‐An, Laurence J. Walsh , et al. · 2024

Genetic testing for Parkinson’s disease (PD) is infrequently performed in clinical settings due to providers’ perception of low utility, yet patients may find the results useful. We investigated the reported personal utility of genetic tes…

Care access and utilization among medicare beneficiaries living with Parkinson’s disease Open

Caroline Pearson, Alex Hartzman, Dianne Munevar, Megan Feeney, Rachel Dolhun , et al. · 2023

Providing genetic testing and genetic counseling for Parkinson’s disease to the community Open

Lola Cook, Jennifer Verbrugge, Tae‐Hwi Schwantes‐An, Jeanine Schulze, James C. Beck , et al. · 2023

Association of Dental Infections with Intracranial Atherosclerotic Stenosis Open

Souvik Sen, Jaclyn Meyer, Rachel Mascari, Tushar Trivedi, Fareed Suri , et al. · 2023

Introduction: Periodontal disease (PD) and dental caries are oral infections leading to tooth loss that are associated with atherosclerosis and cerebrovascular disease. We assessed the hypothesis that PD and caries are associ…

Racial and Ethnic Differences in Health-Related Quality of Life for Individuals With Parkinson Disease Across Centers of Excellence Open

Daniel G. Di Luca, Sheng Luo, Hongliang Liu, Mélanie Cohn, Thomas L. Davis , et al. · 2023

There were differences in PD outcomes across racial and ethnic groups, even after adjustment for sex, disease duration, HY stage, age, and some comorbid conditions. Most notably, there was worse HRQoL among non-White patients when compared…

Informing People with Parkinson's Disease of Their Gene Variant Status: PD GENEration, a North American Observational and Registry Study Open

Roy N. Alcalay, Lola Cook, Jennifer Verbrugge, Tae-Hwi Schwantes, Tatiana Foroud , et al. · 2023

Incidence of Parkinson disease in North America Open

Allison W. Willis, Eric Roberts, James C. Beck, Brian Fiske, Web Ross , et al. · 2022

Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater tha…

Tools for communicating risk for Parkinson’s disease Open

Lola Cook, Jeanine Schulze, Wendy R. Uhlmann, Jennifer Verbrugge, Karen Marder , et al. · 2022

IN-HOME-PD Caregivers: The effects of a combined home visit and peer mentoring intervention for caregivers of homebound individuals with advanced Parkinson's disease Open

Jori Fleisher, Madhuvanthi Suresh, Ellen C. Klostermann, Jeanette Lee, Serena Hess , et al. · 2022

IN-HOME-PD: The effects of longitudinal telehealth-enhanced interdisciplinary home visits on care and quality of life for homebound individuals with Parkinson's disease Open

Jori Fleisher, Serena Hess, Ellen C. Klostermann, Jeanette Lee, Erica Myrick , et al. · 2022

Health Care Utilization of US Medicare Beneficiaries Living with Parkinson’s Disease Open

Caroline Pearson, Alex Hartzman, Dianne Munevar, Megan Feeney, Rachel Dolhun , et al. · 2022

The number of people living with Parkinson’s disease (PD) is expected to rise in the coming years. This study analyzed health care utilization patterns of Medicare beneficiaries with a PD diagnosis (ICD-10 code G20) who were enrolled in 20…

Attitudes Toward Telehealth Services Among People Living With Parkinson's Disease: A Survey Study Open

Yaqian Xu, Megan Feeney, Matthew Surface, Dan Novak, Michelle S. Troche , et al. · 2022

Background Telehealth has been widely adopted in providing Parkinson's disease care during the coronavirus disease 2019 pandemic. Objective The aim of this study was to survey people living with Parkinson's disease (PwPD) about their attit…

Acknowledgment of Ad Hoc Reviewers Open

Chaona Chen, Shuquan Chen, Katie Hoemann, Kevin King, Jessica P. Lougheed , et al. · 2022

The editorial team of Emotion gratefully acknowledges the many individuals who

The commercial genetic testing landscape for Parkinson's disease Open

Lola Cook, Jeanine Schulze, Jennifer Verbrugge, James C. Beck, Karen Marder , et al. · 2021

COVID-19 manifestations in people with Parkinson’s disease: a USA cohort Open

Yaqian Xu, Matthew Surface, Amanda Chan, Joshua A. Halpern, Nora Vanegas‐Arroyave , et al. · 2021

Longitudinal, Interdisciplinary Home Visits Versus Usual Care for Homebound People With Advanced Parkinson Disease: Protocol for a Controlled Trial Open

Jori Fleisher, Serena Hess, Brianna Sennott, Erica Myrick, Ellen C. Klostermann , et al. · 2021

Background The current understanding of advanced Parkinson disease (PD) and its treatment is largely based on data from outpatient visits. The most advanced and disabled individuals with PD are disconnected from both care and research. A p…

Longitudinal, Interdisciplinary Home Visits Versus Usual Care for Homebound People With Advanced Parkinson Disease: Protocol for a Controlled Trial (Preprint) Open

Jori Fleisher, Serena Hess, Brianna Sennott, Erica Myrick, Ellen C. Klostermann , et al. · 2021

BACKGROUND The current understanding of advanced Parkinson disease (PD) and its treatment is largely based on data from outpatient visits. The most advanced and disabled individuals with PD are disconnected from both care and research. A …

Expediting telehealth use in clinical research studies: recommendations for overcoming barriers in North America Open

Anna Naito, Anne‐Marie Wills, Thomas F. Tropea, Adolfo Ramirez‐Zamora, Robert A. Hauser , et al. · 2021

Weeding through the haze: a survey on cannabis use among people living with Parkinson’s disease in the US Open

Megan Feeney, Danny Bega, Benzi M. Kluger, A. Jon Stoessl, Christiana Evers , et al. · 2021

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism Open

Caroline M. Tanner, Steven R. Cummings, Michael A. Schwarzschild, Ethan Brown, E. Ray Dorsey , et al. · 2021

The impact of COVID-19 and social distancing on people with Parkinson’s disease: a survey study Open

Megan Feeney, Yaqian Xu, Matthew Surface, Hiral Shah, Nora Vanegas‐Arroyave , et al. · 2021

Design of a virtual longitudinal observational study in Parkinson’s disease (AT‐HOME PD) Open

Ruth B. Schneider, Larsson Omberg, Eric A. Macklin, Margaret Daeschler, Lauren Bataille , et al. · 2020

Objective The expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site‐centric therapeutic trials in Parkinson’s disease and generate novel insights. The value…

Cross-sectional associations of oral health measures with cognitive function in late middle–aged adults Open

Supawadee Naorungroj, Victor J. Schoenbach, James C. Beck, Thomas H. Mosley, Rebecca F. Gottesman , et al. · 2020

It has not been established to what extent oral health is associated with cognitive function in late middle–aged adults. In this study, which is part of the national Atherosclerosis Risk in Communities (ARIC) study, the authors investigate…

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