James C. Fuscoe
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View article: A comprehensive rat transcriptome built from large scale RNA-seq-based annotation
A comprehensive rat transcriptome built from large scale RNA-seq-based annotation Open
The rat is an important model organism in biomedical research for studying human disease mechanisms and treatments, but its annotated transcriptome is far from complete. We constructed a Rat Transcriptome Re-annotation named RTR using RNA-…
View article: Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism
Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism Open
View article: Transcriptomics analysis of early embryonic stem cell differentiation under osteoblast culture conditions: Applications for detection of developmental toxicity
Transcriptomics analysis of early embryonic stem cell differentiation under osteoblast culture conditions: Applications for detection of developmental toxicity Open
View article: Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
View article: Stably Expressed Genes Involved in Basic Cellular Functions
Stably Expressed Genes Involved in Basic Cellular Functions Open
Stably Expressed Genes (SEGs) whose expression varies within a narrow range may be involved in core cellular processes necessary for basic functions. To identify such genes, we re-analyzed existing RNA-Seq gene expression profiles across 1…
View article: Additional file 5: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Additional file 5: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
43 significantly differentially expressed miRNAs between 52, 78, and 104 weeks of age males and females compared to 5–21 weeks of age baseline group. Presence or absence of histopathological findings is given with the relative fold change …
View article: Additional file 1: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Additional file 1: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
212 differentially expressed miRNAs by age for each sex. The age contrast with differential expression is given along with fold-ratio, ANOVA FDR, degrees of freedom (df), ANOVA F statistic, and p values for both males and females. (XLSX 23…
View article: Additional file 4: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Additional file 4: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
38 miRNAs with 2-week-old-specific expression. Identification of 2-week-old-specific miRNAs, along with expression level in each rat liver sample, k-means cluster number (from Fig. 2), differential expression by age and/or sex, and chromo…
View article: Additional file 2: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Additional file 2: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
214 miRNAs differentially expressed by age and/or sex. Each miRNA is shown as differentially expressed by age, sex, or both age and sex, along with the k-means cluster number from Fig. 2 and chromosome mapping position. (XLSX 20 kb)
View article: Additional file 3: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Additional file 3: of Sex and age differences in the expression of liver microRNAs during the life span of F344 rats Open
Age-related differences in miRNA expression. Identification of miRNAs in Venn diagrams in Fig. 5. (XLSX 26 kb)
View article: Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice Open
Our findings indicate a primary role of hepatic DNA methylation in the pathogenesis of NAFLD and suggest that individual variations in DNA methylation across the genome may be a factor determining and influencing the vulnerability to NAFLD.
View article: Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats
Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats Open
View article: Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma
Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma Open
Published studies have identified genetic variants, somatic mutations and changes in gene expression profiles that are associated with hepatocellular carcinoma (HCC), particularly involving genes that encode drug metabolizing enzymes (DMEs…
View article: Age and sex differences in kidney microRNA expression during the life span of F344 rats
Age and sex differences in kidney microRNA expression during the life span of F344 rats Open
View article: Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages Open
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Moreover, sex and age are considered major risk factors in the development of CVDs. Mitochondria are vital for normal cardiac function, and regulation of mitochondri…