James C. Liao
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View article: Design and Evolution of New Metabolism for Greenhouse Gas Assimilation
Design and Evolution of New Metabolism for Greenhouse Gas Assimilation Open
Nature has evolved several molecular systems to fix one-carbon (C1) compounds such as CO2, methane, and methanol. However, such systems are insufficient to deal with the increased challenge posed by the increased carbon emission due to hum…
View article: Application of Modern Intelligent Algorithms in Retrosynthesis Prediction
Application of Modern Intelligent Algorithms in Retrosynthesis Prediction Open
In recent years, the rapid advancements in computer science have spurred the development of various cutting-edge intelligent algorithms. Among these, the transformer, which is built upon a multi-head attention mechanism, is one of the most…
View article: Effects of Lactobacillus brevis additives on nutrient composition, fermentation quality, microflora structure and metabolites of Pennisetum giganteum silage
Effects of Lactobacillus brevis additives on nutrient composition, fermentation quality, microflora structure and metabolites of Pennisetum giganteum silage Open
The current situation of feed resource shortage can be effectively solved by high-value utilization of Pennisetum giganteum . This study investigated the effects of Lactobacillus brevis R-09 on P. giganteum silage quality, microbial struct…
View article: First experiment using post-accelerated unstable ion beams at BRIF: angular distribution of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si13.svg"> <mml:mrow> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mn>21</mml:mn> <mml:mo>,</mml:mo> <mml:mn>22</mml:mn> </mml:mrow> </mml:msup> <mml:mtext>Na</mml:mtext> </mml:mrow> </mml:math> elastic scattering from doubly magic <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si14.svg"> <mml:mrow> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mn>40</mml:mn> </mml:mrow> </mml:msup> <mml:mtext>Ca</mml:mtext> </mml:mrow> </mml:math>
First experiment using post-accelerated unstable ion beams at BRIF: angular distribution of the elastic scattering from doubly magic Open
View article: Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma
Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma Open
The persistence of chimeric antigen receptor (CAR) T cells in the tumor microenvironment limits their antitumor effects against solid tumors. Many studies have reported that the in vitro phenotype and metabolism of CAR-T cells corre…
View article: Optimization design of structural parameters for porous media permeable nozzle
Optimization design of structural parameters for porous media permeable nozzle Open
The porous media permeable nozzle has garnered significant attention due to its superior low-altitude compensation abilities. However, research has shown that permeable nozzles with good low-altitude compensation performance often suffer f…
View article: Evaluating disability, comorbidities and risk factors after TB treatment: an 18–24 month follow-up
Evaluating disability, comorbidities and risk factors after TB treatment: an 18–24 month follow-up Open
BACKGROUNDSeveral countries have developed national strategic plans to address post-TB disability and comorbidities. However, their feasibility and added value within routine programmatic settings remain undocumented.METHODSWe followed up …
View article: Multi-strategy hybrid adaptive dung beetle optimization for UAV photogrammetric 3D path planning under complex constraints
Multi-strategy hybrid adaptive dung beetle optimization for UAV photogrammetric 3D path planning under complex constraints Open
Three-dimensional UAV path planning necessitates strong global search capabilities due to its high-dimensional optimization nature. To address premature convergence and enhance local search efficiency in comparison to traditional DBO metho…
View article: Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice
Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice Open
Curcumin, recognized for its antioxidant and anti-inflammatory properties, is a promising dietary supplement for liver protection. However, its role in preventing obesity-induced hepatic steatosis is not fully understood. This study aims t…
View article: Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions
Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions Open
View article: Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO <sub>2</sub> @Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy
Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO <sub>2</sub> @Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy Open
Despite the promise of sonodynamic therapy (SDT)‐mediated immunotherapy, the anticancer efficacy of current sonosensitizers is greatly limited by the immunosuppressive tumor microenvironment (TME) and their inability to selectively respond…
View article: Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer
Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer Open
Objective Given the limitations of immunotherapy for treating non-small cell lung cancer (NSCLC), we investigated the phenotype and function of exhausted CD8 + T cells and analyzed a novel combination immunotherapy to restore the effector …
View article: Ccl-Net: An Conflict-Based Collaborative Learning Net for Semi-Supervised Medical Image Segmentation
Ccl-Net: An Conflict-Based Collaborative Learning Net for Semi-Supervised Medical Image Segmentation Open
View article: Lsrl-Net: A Level Set-Guided Re-Learning Network for Semi-Supervised Cardiac and Prostate Segmentation
Lsrl-Net: A Level Set-Guided Re-Learning Network for Semi-Supervised Cardiac and Prostate Segmentation Open
View article: Evolutionary engineering of methylotrophic E. coli enables fast growth on methanol
Evolutionary engineering of methylotrophic E. coli enables fast growth on methanol Open
View article: SWI/SNF family mutations in advanced NSCLC: genetic characteristics and immune checkpoint inhibitors’ therapeutic implication
SWI/SNF family mutations in advanced NSCLC: genetic characteristics and immune checkpoint inhibitors’ therapeutic implication Open
View article: Evolution engineering of methylotrophic E. coli enables faster growth than native methylotrophs
Evolution engineering of methylotrophic E. coli enables faster growth than native methylotrophs Open
As methanol can be derived from either CO 2 or methane, methanol economy may play a role in combating climate change. In this scenario, rapid utilization of methanol by an industrial microorganism is the first and crucial step for efficien…
View article: Design and Evolution for New Metabolism with Speed and Scale
Design and Evolution for New Metabolism with Speed and Scale Open
View article: Author Correction: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria
Author Correction: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria Open
View article: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria Open
View article: Engineering of metabolic control
Engineering of metabolic control Open
The invention features a method of producing heterologous molecules in cells under the regulatory control of a metabolite and metabolic flux. The method can enhance the synthesis of heterologous polypeptides and metabolites.
View article: Biofuel production by recombinant microorganisms
Biofuel production by recombinant microorganisms Open
Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-…
View article: Recombinant microorganisms having a methanol elongation cycle (MEC)
Recombinant microorganisms having a methanol elongation cycle (MEC) Open
Provided are microorganisms that catalyze the synthesis of chemicals and biochemicals from a methanol, methane and/or formaldehyde. Also provided are methods of generating such organisms and methods of synthesizing chemicals and biochemica…
View article: Method for producing aldehyde from CO.sub.2
Method for producing aldehyde from CO.sub.2 Open
The invention provides recombinant microorganisms capable of producing isobutyraldehyde using CO.sub.2 as a carbon source. The invention further provides methods of preparing and using such microorganisms to produce isobutyraldehyde.
View article: Electro-autotrophic synthesis of higher alcohols
Electro-autotrophic synthesis of higher alcohols Open
The disclosure provides a process that converts CO.sub.2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels th…
View article: Biofuel and chemical production by recombinant microorganisms via fermentation of proteinaceous biomass
Biofuel and chemical production by recombinant microorganisms via fermentation of proteinaceous biomass Open
Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed resul…
View article: SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron
SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron Open
View article: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria Open
Regulation of CO2 fixation in cyanobacteria is important both for the organism and the global carbon balance. Here we show that phosphoketolase in Synechococcus elongatus PCC7942 (SeXPK) possesses a distinct ATP sensing mechanis…
View article: Rural Tourism Marketing Strategy under Natural Protection Environment Based on Deep Learning
Rural Tourism Marketing Strategy under Natural Protection Environment Based on Deep Learning Open
With the development of rural tourism, rural tourism has become one of the fastest growing industries in China's tourism industry.However, the current marketing strategy of rural tourism is relatively simple, which is difficult to meet the…
View article: University Scientific Research Management based on Decision Tree Algorithm Evaluation
University Scientific Research Management based on Decision Tree Algorithm Evaluation Open
The evaluation of scientific research(SR) management in China started late, but developed rapidly.It was not until the 1980s that we began to really pay attention to SR projects and carry out substantive management evaluation activities.Ho…