James C. Murphy
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View article: EMG1 methyltransferase activity affects ribosome occupancy at KSHV uORFs
EMG1 methyltransferase activity affects ribosome occupancy at KSHV uORFs Open
Viruses lack their own translational machinery and rely exclusively on the host cell for synthesis of viral proteins. Viruses have evolved diverse mechanisms to redirect the host cell translation apparatus to favor viral transcripts. A uni…
View article: EMG1 methyltransferase activity regulates ribosome occupancy at viral uORFs
EMG1 methyltransferase activity regulates ribosome occupancy at viral uORFs Open
Summary Viruses do not encode their own translational machinery and rely exclusively on the translational machinery of the host cell for the synthesis of viral proteins. Viruses have evolved diverse mechanisms to redirect the cellular tran…
View article: Kaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs
Kaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs Open
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which…
View article: The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex
The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex Open
Human respiratory syncytial virus (HRSV) is a leading cause of respiratory illness, particularly in the young, elderly, and immunocompromised, and has also been linked to the development of asthma. HRSV replication depends on P and L, wher…
View article: Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD
Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD Open
Viral-bacterial co-infections are associated with severe exacerbations of COPD. Epithelial antimicrobial peptides, including human β-defensin-2 (HBD-2), are integral to innate host defenses. In this study, we examined how co-infection of a…