James C. S. Ho
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View article: Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte (Adv. Mater. Interfaces 20/2025)
Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte (Adv. Mater. Interfaces 20/2025) Open
View article: Direct Partial Oxidation of Methane to Methanol at Plasma-Catalyst-Liquid Interfaces
Direct Partial Oxidation of Methane to Methanol at Plasma-Catalyst-Liquid Interfaces Open
The direct and selective partial oxidation of methane to methanol remains a major challenge in chemistry. Here, we introduce engineered plasma-catalyst-liquid interfaces that enable a one-step, ambient pressure, and room temperature pathwa…
View article: Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte
Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte Open
Conjugated oligoelectrolytes (COEs) spontaneously intercalate into and modulate lipid membranes thanks to their hydrophobic backbone and hydrophilic ionic termini, enabling applications in biosensing, fluorescence imaging, antimicrobial th…
View article: Accelerated carbon dioxide mineralization and polymorphic control facilitated by nonthermal plasma bubbles
Accelerated carbon dioxide mineralization and polymorphic control facilitated by nonthermal plasma bubbles Open
Underwater plasma discharges accelerated carbon capture and mineralization.
View article: Intravesicular Solute Delivery and Surface Area Regulation in Giant Unilamellar Vesicles Driven by Cycles of Osmotic Stresses
Intravesicular Solute Delivery and Surface Area Regulation in Giant Unilamellar Vesicles Driven by Cycles of Osmotic Stresses Open
Phospholipid bilayers are dynamic cellular components that undergo constant changes in their topology, facilitating a broad diversity of physiological functions including endo- and exocytosis, cell division, and intracellular trafficking. …
View article: Volume 44 Number 2
Volume 44 Number 2 Open
Recent studies on the formation, organisation and dynamics of biofilms highlight the interplay between physical forces and biological programs.Two complementary generalised pathways that explain the mechanisms driving biofilm formation hav…
View article: Viewing biofilm formation through a multifocal lens of physics and biology
Viewing biofilm formation through a multifocal lens of physics and biology Open
Recent studies on the formation, organisation and dynamics of biofilms highlight the interplay between physical forces and biological programs. Two complementary generalised pathways that explain the mechanisms driving biofilm formation ha…
View article: Surface-layer protein is a public-good matrix exopolymer for microbial community organisation in environmental anammox biofilms
Surface-layer protein is a public-good matrix exopolymer for microbial community organisation in environmental anammox biofilms Open
Extracellular polymeric substances (EPS) are core biofilm components, yet how they mediate interactions within and contribute to the structuring of biofilms is largely unknown, particularly for non-culturable microbial communities that pre…
View article: Mechanisms of a Mycobacterium tuberculosis Active Peptide
Mechanisms of a Mycobacterium tuberculosis Active Peptide Open
Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. Previously, we identified a cationic host defense peptide with activity against Mycobacterium tuberculosis in vivo and with a bactericidal effect against M…
View article: Biomimetic Stratum Corneum Liposome Models: Lamellar Organization and Permeability Studies
Biomimetic Stratum Corneum Liposome Models: Lamellar Organization and Permeability Studies Open
The stratum corneum (SC), the outer layer of the skin, plays a crucial role as a barrier protecting the underlying cells from external stress. The SC comprises three key components: ceramide (CER), free fatty acid (FFA), and cholesterol, a…
View article: Microbial biofilms are shaped by the constant dialogue between biological and physical forces in the extracellular matrix
Microbial biofilms are shaped by the constant dialogue between biological and physical forces in the extracellular matrix Open
The biofilm matrix, with its diversity of extracellular polymeric substances (EPS), remains a poorly understood entity. It consists of a heterogeneous, multifunctional microenvironment that imparts a range of emergent properties to the bio…
View article: Surfactant-Mediated Solubilization of Myelin Figures: A Multistep Morphological Cascade
Surfactant-Mediated Solubilization of Myelin Figures: A Multistep Morphological Cascade Open
Lamellar mesophases of insoluble lipids are readily solubilized by the micellar mesophases of soluble surfactants. This simple process underscores a broad array of biochemical methodologies, including purification, reconstitution, and crys…
View article: Amphiphilic Membrane Environments Regulate Enzymatic Behaviors of <i>Salmonella</i> Outer Membrane Protease
Amphiphilic Membrane Environments Regulate Enzymatic Behaviors of <i>Salmonella</i> Outer Membrane Protease Open
The role of an amphiphilic environment in the functional regulation of integral membrane proteins is well appreciated but how specific amphiphilic surrounding influences the conformational plasticity and function of a protein is less obvio…
View article: A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate Open
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and r…
View article: Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex Open
View article: Gram Typing: Gram‐Typing Using Conjugated Oligoelectrolytes (Adv. Funct. Mater. 42/2020)
Gram Typing: Gram‐Typing Using Conjugated Oligoelectrolytes (Adv. Funct. Mater. 42/2020) Open
In article number 2004068, Jamie Hinks, Guillermo C. Bazan, and co-workers develop a membrane-specific fluorescent dye that selectively stains Gram-positive bacteria based on a conjugated oligoelectrolyte molecular structure. The conjugate…
View article: Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments
Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments Open
A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can cre…
View article: Facile Mixing of Phospholipids Promotes Self-Assembly of Low-Molecular-Weight Biodegradable Block Co-Polymers into Functional Vesicular Architectures
Facile Mixing of Phospholipids Promotes Self-Assembly of Low-Molecular-Weight Biodegradable Block Co-Polymers into Functional Vesicular Architectures Open
In this work, we have used low-molecular-weight (PEG12-b-PCL6, PEG12-b-PCL9 or PEG16-b-PLA38; MW, 1.25–3.45 kDa) biodegradable block co-polymers to construct nano- and micron-scaled hybrid (polymer/lipid) vesicles, by solvent dispersion an…
View article: Conjugated Oligoelectrolytes: A Chain‐Elongated Oligophenylenevinylene Electrolyte Increases Microbial Membrane Stability (Adv. Mater. 18/2019)
Conjugated Oligoelectrolytes: A Chain‐Elongated Oligophenylenevinylene Electrolyte Increases Microbial Membrane Stability (Adv. Mater. 18/2019) Open
Achieving biotechnological strain improvement using synthetic materials represents a simple approach compared to genetic techniques. In article 1808021, Jamie Hinks, Guillermo C. Bazan, and co-workers demonstrate a novel membrane-intercala…
View article: Minimal Reconstitution of Membranous Web Induced by a Vesicle–Peptide Sol–Gel Transition
Minimal Reconstitution of Membranous Web Induced by a Vesicle–Peptide Sol–Gel Transition Open
Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous…
View article: Response of microbial membranes to butanol: interdigitation<i>vs.</i>disorder
Response of microbial membranes to butanol: interdigitation<i>vs.</i>disorder Open
Elucidating butanol interactions with lipid bilayers will inform membrane engineering approaches for improving butanol tolerance in industrial fermentations.
View article: Nanoplasmonic Sensing from the Human Vision Perspective
Nanoplasmonic Sensing from the Human Vision Perspective Open
Localized surface plasmon resonance (LSPR) constitutes a versatile technique for biodetection, exploiting the sensitivity of plasmonic nanostructures to small changes in refractive index. The optical shift in the LSPR band caused by molecu…
View article: Volume and Surface Area Dynamics of Giant Unilamellar Vesicles
Volume and Surface Area Dynamics of Giant Unilamellar Vesicles Open
View article: Pulsatile Lipid Vesicles under Osmotic Stress
Pulsatile Lipid Vesicles under Osmotic Stress Open
View article: Osmotic Pulsations of Lipid Vesicles under Hypotonic Stress
Osmotic Pulsations of Lipid Vesicles under Hypotonic Stress Open
View article: Protein-dependent Membrane Interaction of A Partially Disordered Protein Complex with Oleic Acid: Implications for Cancer Lipidomics
Protein-dependent Membrane Interaction of A Partially Disordered Protein Complex with Oleic Acid: Implications for Cancer Lipidomics Open
Bovine α-lactalbumin (BLA) forms cytotoxic complexes with oleic acid (OA) that perturbs tumor cell membranes, but molecular determinants of these membrane-interactions remain poorly understood. Here, we aim to obtain molecular insights int…
View article: Pulsatile lipid vesicles under osmotic stress
Pulsatile lipid vesicles under osmotic stress Open
The response of lipid bilayers to osmotic stress is an important part of cellular function. Previously, in (Oglecka et al., 2014), we reported that cell-sized giant unilamellar vesicles (GUVs) exposed to hypotonic media, respond to the osm…
View article: Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity
Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity Open
Using single-particle tracking, we investigate the interaction of small unilamellar vesicles (SUVs) that are electrostatically tethered to the freestanding membrane of a giant unilamellar vesicle (GUV). We find that the surface mobility of…
View article: Urinary Tract Infection Molecular Mechanisms and Clinical Translation
Urinary Tract Infection Molecular Mechanisms and Clinical Translation Open
Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance t…
View article: Irreversible Thermodynamics of Lipid Vesicles under Osmotic Stress
Irreversible Thermodynamics of Lipid Vesicles under Osmotic Stress Open