James D. Eason
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View article: Comparative Landscape of Small RNAs in Tissue and Liquid Biopsies for Liver Transplant Outcomes
Comparative Landscape of Small RNAs in Tissue and Liquid Biopsies for Liver Transplant Outcomes Open
Background Ischemia-reperfusion injury (IRI) is an inevitable consequence of liver transplantation, arising during donor organ procurement and reoxygenation. Severe IRI is a leading contributor to early allograft dysfunction (EAD), a post-…
View article: Unveiling APOL1 haplotypes in a predominantly African-American cohort of kidney transplant patients: a novel classification using probe-independent quantitative real-time PCR
Unveiling APOL1 haplotypes in a predominantly African-American cohort of kidney transplant patients: a novel classification using probe-independent quantitative real-time PCR Open
Introduction Apolipoprotein-L1 (APOL1) is a primate-specific protein component of high-density lipoprotein (HDL). Two variants of APOL1 (G1 and G2), provide resistance to parasitic infections in African Americans but are also implicated in…
View article: Which cava anastomotic techniques are optimal regarding immediate and short‐term outcomes after liver transplantation: A systematic review of the literature and expert panel recommendations
Which cava anastomotic techniques are optimal regarding immediate and short‐term outcomes after liver transplantation: A systematic review of the literature and expert panel recommendations Open
Background It has long been debated whether cava anastomosis should be performed with the piggyback technique or cava replacement, with or without veno‐venous bypass (VVB), with or without temporary portocaval shunt (PCS) in the setting of…
View article: MicroRNAs: Novel Targets in Hepatic Ischemia–Reperfusion Injury
MicroRNAs: Novel Targets in Hepatic Ischemia–Reperfusion Injury Open
Hepatic ischemia–reperfusion injury (IRI) is one of the main factors for early allograft dysfunction (EAD), which may lead to graft rejection, graft loss, or shortened graft life in liver transplantation. Hepatic IRI appears to be inevitab…
View article: Artificial Intelligence May Predict Early Sepsis After Liver Transplantation
Artificial Intelligence May Predict Early Sepsis After Liver Transplantation Open
Background: Sepsis, post-liver transplantation, is a frequent challenge that impacts patient outcomes. We aimed to develop an artificial intelligence method to predict the onset of post-operative sepsis earlier. Methods: This pilot study a…
View article: FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury Open
Dendritic cells (DCs) are central in regulating immune responses of kidney ischemia-reperfusion injury (IRI), and strategies to alter DC function may provide new therapeutic opportunities. Sphingosine 1-phosphate (S1P) modulates immunity t…
View article: Longitudinal Renal Function in Liver Transplant Recipients With Acute-on-Chronic Liver Failure
Longitudinal Renal Function in Liver Transplant Recipients With Acute-on-Chronic Liver Failure Open
INTRODUCTION: To analyze the impact of acute-on-chronic liver failure (ACLF) immediately before liver transplantation (LT) on short-term kidney function. METHODS: In this retrospective study, we included 416 of 687 consecutive patients who…
View article: Validation of Prognostic Index for Allograft Outcome in Kidney Transplant Recipients With Transplant Glomerulopathy
Validation of Prognostic Index for Allograft Outcome in Kidney Transplant Recipients With Transplant Glomerulopathy Open
Transplant glomerulopathy (TG) is a histological lesion of kidney allograft characterized by thickening or duplication of glomerular basement membrane, double contour formation, and mesangial interposition seen on light and electron micros…
View article: Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference
Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference Open
Liver transplantation (LT) for unresectable colorectal liver metastases has long been abandoned because of dismal prognoses. After the dark ages, advances in chemotherapy and diagnostic imaging have enabled strict patient selection, and th…
View article: The incidence of cytomegalovirus infection after deceased-donor kidney transplantation from hepatitis-C antibody positive donors to hepatitis-C antibody negative recipients
The incidence of cytomegalovirus infection after deceased-donor kidney transplantation from hepatitis-C antibody positive donors to hepatitis-C antibody negative recipients Open
Deceased-donor kidney transplantation (KT) from hepatitis C (HCV)-infected donors into HCV-uninfected recipients (HCV D+/R−) could become standard care in the near future. However, HCV viral replication by viral transmission might lead to …
View article: Association between longer hospitalization and development of <i>de novo</i> donor specific antibodies in simultaneous liver–kidney transplant recipients
Association between longer hospitalization and development of <i>de novo</i> donor specific antibodies in simultaneous liver–kidney transplant recipients Open
Background: De novo Donor Specific Antibodies (DSA) are considered as a risk factor for the kidney allograft outcomes in recipients after simultaneous liver-kidney transplantation (SLKT). We hypothesized that length of hospital stay (LOS) …
View article: Association between post‐transplant donor‐specific antibodies and recipient outcomes in simultaneous liver–kidney transplant recipients: single‐center, cohort study
Association between post‐transplant donor‐specific antibodies and recipient outcomes in simultaneous liver–kidney transplant recipients: single‐center, cohort study Open
There is a dearth of published data regarding the presence of post-transplant donor-specific antibodies (DSA), especially C1q-binding DSA (C1q+DSA), and patient and kidney allograft outcomes in simultaneous liver-kidney transplant (SLKT) r…
View article: Outcomes of Liver Transplant Recipients With Autoimmune Liver Disease Using Long-Term Dual Immunosuppression Regimen Without Corticosteroid
Outcomes of Liver Transplant Recipients With Autoimmune Liver Disease Using Long-Term Dual Immunosuppression Regimen Without Corticosteroid Open
Background Liver transplant (LT) recipients with autoimmune liver disease (primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis) are at increased risk of developing acute cellular rejection (ACR), and in many c…
View article: Cardiovascular mortality among liver transplant recipients with nonalcoholic steatohepatitis in the United States-a retrospective study
Cardiovascular mortality among liver transplant recipients with nonalcoholic steatohepatitis in the United States-a retrospective study Open
Nonalcoholic steatohepatitis (NASH) has become an increasingly important indication for liver transplantation (LT), and there has been a particular concern of excessive cardiovascular-related mortality in this group. Using the United Netwo…
View article: Do we really need more evidence to use hepatitis C positive donor kidney more liberally?
Do we really need more evidence to use hepatitis C positive donor kidney more liberally? Open
The number of patients listed active for kidney transplantation has continued to rise over the last 10 years, leading to significantly increased wait-list time for patients awaiting kidney transplantation in the USA. This increased demand …
View article: An aggressive case of sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid: a case report
An aggressive case of sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid: a case report Open
Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia (SMECE) of the thyroid is a rare disease with approximately 50 cases reported worldwide. We describe SMECE of the thyroid affecting a 44 year old female and the first reported c…
View article: Outcome of Liver Transplant Recipients With Revascularized Coronary Artery Disease
Outcome of Liver Transplant Recipients With Revascularized Coronary Artery Disease Open
Severity or extent of CAD does not impact post-LT survival, if appropriately revascularized. Early postoperative cardiac events are associated with inferior survival in LT recipients, irrespective of underlying CAD.
View article: Simultaneous Liver—Kidney Transplantation
Simultaneous Liver—Kidney Transplantation Open
In 2014, simultaneous liver kidney transplants (SLK) accounted for 8.2 % of all liver transplants performed in the USA. Prior to introduction of the model of end stage liver disease (MELD) system, SLK accounted for 2.5 % in 2001 and only 1…