Explanipedia

Racial and Ethnic Minorities Are Underrepresented Among Studies Informing North American Spine Society Appropriate Use Criteria for Degenerative Spine Conditions Open

Jason Silvestre, Robert J. Ferdon, S Bradley, Robert Ravinsky, James P. Lawrence , et al. · 2025

Study Design Comparative study. Objectives To compare the racial and ethnic representation of study participants in primary literature used to develop North American Spine Society (NASS) appropriate use criteria (AUCs) relative to their pr…

Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective Open

Charu Jain, James Huang, Yunsoo Lee, Saad B. Chaudhary, Andrew C. Hecht , et al. · 2025

Background Intervertebral disc (IVD) degeneration (IVDD) is a major cause of global disability. Three papers on puncture models of IVDD were published 20 years ago, transforming the application of preclinical animal models for pathophysiol…

Clinical outcomes and risk factors of Pneumocystis jirovecii pneumonia in pediatric acute lymphoblastic leukemia: a 10-year single-center study Open

Sungsu Jung, Eunha Hwang, James D. Kang, Younga Kim · 2025

0684 Modified Scoring Criteria to Improve Accuracy of the Home Sleep Apnea Test Open

Philip Cushman, Matthew Brock, Zahari Tchopev, Aaron Burch, James D. Kang , et al. · 2025

Introduction The Home Sleep Apnea Test (HSAT) has good diagnostic performance for patients with a high pretest probability of moderate to severe obstructive sleep apnea (OSA). However, the false negative rate has been reported to range fro…

1184 Enhancing Diagnosis of Nightmare Disorder at an Academic Sleep Disorders Center: A Quality Improvement Initiative Open

Andrea Radtke, Aaron Burch, James D. Kang, Philip Cushman, H Samuel Scheuller , et al. · 2025

Introduction Nightmare Disorder (NDO) is estimated to impact at least 4% of the US adult population yet is reported to be much higher among service members (SMs). Our Center has previously reported 31.2% of referred SMs had probable NDO ba…

1263 Understanding Bedtime Procrastination in the Military Population Open

Aaron Burch, Lauren Cornell, Jordan M. Ellis, Catherine Holtz, Tarjani Shukla , et al. · 2025

Introduction Bedtime procrastination (BP) is considered a form of self-harm. BP contributes to insufficient sleep leading to multiple negative cognitive and physiologic sequelae. The prevalence of BP is not currently established among mili…

Postural control adaptations to different visual conditions in dancers and non-dancers with chronic ankle instability Open

Eun Ji Hong, James D. Kang, Hyung Gyu Jeon, Sae Yong Lee, Kyeongtak Song · 2025

Purpose Even though dancers have good postural control ability, ankle sprain is the most common injury among dancers, developing into chronic ankle instability (CAI). While dancers rely on visual cues during stage and practice, it is unkno…

Issue Information Open

Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2024

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting <span>mTORC1</span> and inducing autophagy through Akt activation Open

Takashi Yurube, William Buchser, Zhongying Zhang, Prashanta Silwal, Michael T. Lotze , et al. · 2024

Background Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) si…

Musculoskeletal health: an ecological study assessing disease burden and research funding Open

Andrew Nguyen, Izzuddin M. Aris, Brian D. Snyder, Mitchel B. Harris, James D. Kang , et al. · 2024

No funding.

Cellular behavior and extracellular matrix turnover in bovine annulus fibrosus cells under hydrostatic pressure and deviatoric strain Open

Ryo Taiji, James D. Kang, Shuichi Mizuno · 2023

Intervertebral disc herniation is a common spinal disorder that is often treated with discectomy when conservative measures fail. To devise therapeutic strategies for tears in the annulus fibrosus (AF), the regenerative capability of AF ce…

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Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2023

THE DOUBLE BIND: AN ETHICAL CONUNDRUM OF A BRAIN-DEAD PREGNANT PATIENT IN THE ICU Open

James D. Kang, BHANU SIVA KUMAR S. SABBULA, SHIVA M. ARJUN, JAGADISH AKELLA, Javed Iqbal , et al. · 2023

Geriatric Surgery Produces a Hypoactive Molecular Phenotype in the Monocyte Immune Gene Transcriptome Open

Rachel Oren, Rachel Grasfield, Matthew B. Friese, Lori B. Chibnik, H. John , et al. · 2023

Surgery is a major challenge for the immune system, but little is known about the immune response of geriatric patients to surgery. We therefore investigated the impact of surgery on the molecular signature of circulating CD14+ monocytes, …

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Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2023

Regenerative Capability of Human Nucleus Pulposus Cells in Degenerated Disc Under Hydrostatic Pressure Mimicking Physiologically Relevant Intradiscal Pressure In Vitro Open

Yoshiki Takeoka, Yutaro Kanda, James D. Kang, Shuichi Mizuno · 2023

Study Design. Isolated human nucleus pulposus (hNP) cells from the degenerated intervertebral disc (IVD) were incubated under hydrostatic pressure (HP) and evaluated for regenerative potential. Objectives. To characterize metabolic turnove…

Gene Therapy for Intervertebral Disc Degeneration: An Overview of Current Strategies and Applications Open

Melissa Tang, Gwendolyn Sowa, Joon Lee, Nam Vo, James D. Kang · 2023

Intervertebral disc degeneration is a pervasive condition contributing to chronic back pain, affecting up to a third of the population, with risk further increasing with age. It is a significant driver of disability for millions of America…

In-Hospital, 24-Hour Exercise Spaces for Resident and Staff Wellness Open

Harry M. Lightsey, Stephen P. Maier, Christopher M. Bono, James D. Kang, Mitchel B. Harris · 2022

Issue Information Open

Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2022

Issue Information Open

Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2022

Automatic detection and voxel-wise mapping of

Expression of matrix factors in the process of neovascularization of intervertebral disc Open

Pedro Henrique Isoldi Pohl, Thais Cuperman, Thomas P. Lozito, Takashi Yurube, Rocky S. Tuan , et al. · 2022

OBJECTIVE: To investigate the effects of proteins products of endothelial cells (ECs) on the annulus fibrosus (AF) cell metabolism in an in vitro culture.METHODS:Human AF cells were expanded in monolayer cultures and treated with proteins …

Assessing the quality of shared decision making for elective orthopedic surgery across a large healthcare system: cross-sectional survey study Open

K. D. Valentine, Tom Cha, John Giardina, Felisha Marques, Steven J. Atlas , et al. · 2021

Table of Contents Open

Richard Iorio, Patrick R. Peavy, David E. Keyes, Susan M. Dempsey, David R. McCready , et al. · 2021

Augmented Chondroitin Sulfate Proteoglycan Has Therapeutic Potential for Intervertebral Disc Degeneration by Stimulating Anabolic Turnover in Bovine Nucleus Pulposus Cells under Changes in Hydrostatic Pressure Open

Yoshiki Takeoka, Phani Paladugu, James D. Kang, Shuichi Mizuno · 2021

Nucleus pulposus (NP) cells are exposed to changes in hydrostatic pressure (HP) and osmotic pressure within the intervertebral disc. We focused on main disc matrix components, chondroitin sulfate proteoglycan (CSPG) and hyaluronan (HA) to …

Issue Information Open

Mauro Alini, Robert L. Mauck, Daisuke Sakai, Lorin M. Benneker, Lawrence Bonassar , et al. · 2021

Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs Open

Dong Wang, Robert A. Hartman, Chao Han, Chaoming Zhou, Brandon K. Couch , et al. · 2021

Correction to: ISSLS prize in basic science 2021: a novel inducible system to regulate transgene expression of TIMP1 Open

Yingchao Han, Zhi-Hua Ouyang, Richard A. Wawrose, Stephen H. Chen, Maximiliane Hallbaum , et al. · 2021

ISSLS prize in basic science 2021: a novel inducible system to regulate transgene expression of TIMP1 Open

Yingchao Han, Zhihua Ouyang, Richard A. Wawrose, Stephen H. Chen, Maximiliane Hallbaum , et al. · 2021

Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial Open

K. Mikayla Flowers, Megan E Patton, Valerie Hruschak, Kara G. Fields, Emily Schwartz , et al. · 2021

Placebo effects have traditionally involved concealment or deception. However, recent evidence suggests that placebo effects can also be elicited when prescribed transparently as “open-label placebos” (OLPs), and that the pairing of an unc…

Additional file 1 of Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs Open

Dong Wang, Robert A. Hartman, Chao Han, Chaoming Zhou, Brandon K. Couch , et al. · 2021

Additional file 1: Figure S1. Lactate tolerance by AF cells in cell culture. Rabbit AF cells were grown on monolayer culture under physiologic nutrients, e.g. 1% FBS, 1.06 mM glucose and varying exogenously added lactate concentrations (0-…

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