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View article: Supplementary Table 5 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Table 5 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
RNASeq data for the MDA cohort (n=61) with associated clinical info.
View article: Supplementary Figure S4 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S4 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Immune cell analysis by BMI. A. Immunohistochemistry (IHC) analysis for CD8-, CD45RO-, FOXP3-, CD68-, GZMB-, PD-1-, LAG-3-, and CD3-positive cells in overweight/obese (OW/OB) verse normal (NL) tumors as defined by body mass index from the …
View article: Supplementary Table 3 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Table 3 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Differential gene expression analysis for each subgroup.
View article: Supplementary Figure S6 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S6 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Direct metabolite measurements from a subset of The Cancer Genome Atlas (TCGA) cohort. Comparison of additional tricarboxylic acid cycle metabolites measured by liquid chromatography/mass spectrometry between metastatic melanoma tumors fro…
View article: Supplementary Table 2 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Table 2 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Differential gene expression analysis for covariates controlled.
View article: Supplementary Figure S5 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S5 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Immune cell analysis by BMI and sex. A. Immunohistochemistry (IHC) analysis of the MDA cohort stratified by BMI and sex. Line represents median +/- interquartile range; each dot represents a single tumor. B. IHC analysis of the Gide cohort…
View article: Supplementary Tables 1 and 6-8 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Tables 1 and 6-8 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Supplementary Table 1: Baseline characteristics for patients included in the integrated gene set enrichment analysis (Figure 2-3) by cohort; Supplementary Table 6: The most frequent somatic alterations (alts) in patients with regionally me…
View article: Supplementary Figure S7 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S7 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Beta-diversity analysis stratified by sex based on Bray-Curtis dissimilarity represents microbiome samples with metastatic melanoma in terms of the two top principal components (explaining around 17% of variance) obtained from the principa…
View article: Supplementary Figure S2 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S2 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Reverse phase protein array of the PI3K pathway expression by BMI. Box plot represents the median bar with the box bounding IQR and whiskers the minimum and maximum values.
View article: Supplementary Figure S1 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Figure S1 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Integrated gene set enrichment analysis by body mass index (BMI) with correction for S phase. This figure presents a dotplot of genes differentially up- or downregulated in OW/OB patients versus NL BMI patients. Red indicates upregulation …
View article: Supplementary Table 4 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Supplementary Table 4 from Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma Open
Body mass index values by patient ID for all RNASeq cohorts.
View article: Low and uneven rural road lighting coverage in Africa
Low and uneven rural road lighting coverage in Africa Open
Africa’s rapid urbanization and infrastructure expansion are driving demand for road lighting across the continent. However, the current knowledge regarding road lighting coverage is fragmented. Here, we employed high-resolution nighttime …
View article: ASO Visual Abstract: Skeletal Muscle Gauge as a Prognosticator of Survival in Resected Early-Stage Non-Small Cell Lung Cancer
ASO Visual Abstract: Skeletal Muscle Gauge as a Prognosticator of Survival in Resected Early-Stage Non-Small Cell Lung Cancer Open
View article: CT-based emphysema score is associated with prolonged air leak after lung resection: a retrospective cohort study
CT-based emphysema score is associated with prolonged air leak after lung resection: a retrospective cohort study Open
View article: Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance
Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance Open
Bacillus Calmette‐Guérin (BCG) immunotherapy is limited by resistance in ∼50% of patients, linked to tumor microenvironment (TME) angiogenesis. The work explored if BCG‐activated tumor‐associated macrophages (TAMs) drive angiogenesis via h…
View article: Primary breast diffuse large B-cell lymphoma (germinal center B-cell-like subtype): a case report and literature review
Primary breast diffuse large B-cell lymphoma (germinal center B-cell-like subtype): a case report and literature review Open
Background Primary breast lymphoma (PBL) is a rare type of extranodal lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype. Due to its nonspecific clinical and imaging features, PBL is frequently…
View article: Clinical utility of a small diameter four-row stapler reload for large vessel transection in lung transplants
Clinical utility of a small diameter four-row stapler reload for large vessel transection in lung transplants Open
Background In lung transplantation, there are multiple factors that can contribute to the need for a left atrial cuff reconstruction. While donor and recipient anatomy are inherent considerations during the procedure, other factors like ty…
View article: An Energy-Efficient Multi-Objective Optimization Framework for QoS-Aware Resource Allocation in 5G Slicing Networks
An Energy-Efficient Multi-Objective Optimization Framework for QoS-Aware Resource Allocation in 5G Slicing Networks Open
This paper investigates decision optimization for wireless resource allocation and energy-efficient scheduling in multi-user, multi-task 5G network slicing scenarios. We propose a hybrid computational framework combining particle swarm opt…
View article: Epidemiology, drug resistance, and clinical risk factors of peritoneal dialysis-associated peritonitis: a five-year multicenter study
Epidemiology, drug resistance, and clinical risk factors of peritoneal dialysis-associated peritonitis: a five-year multicenter study Open
Background Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication in long-term dialysis patients, leading to significant morbidity and healthcare burden. This study aimed to investigate the microbial spectrum, antim…
View article: High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics
High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics Open
View article: Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells
Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells Open
Dysregulated expression of circular RNAs (circRNAs) has been implicated in the initiation and progression of various diseases, including cancer. In this study, we investigated the role of hsa_circ_0005571 in modulating the biological chara…
View article: The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies
The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies Open
Background Low-intensity transcranial ultrasound stimulation (LITUS) is an emerging non-invasive neuromodulation technique for pain treatment, with the unique ability to modulate deep brain nuclei associated with pain. The aim of this stud…
View article: 0779 Topical 5-fluorouracil more effectively eliminates epidermal clonal mutations than photodynamic therapy in a mouse model of early UV carcinogenesis
0779 Topical 5-fluorouracil more effectively eliminates epidermal clonal mutations than photodynamic therapy in a mouse model of early UV carcinogenesis Open
View article: MurreNet: Modeling Holistic Multimodal Interactions Between Histopathology and Genomic Profiles for Survival Prediction
MurreNet: Modeling Holistic Multimodal Interactions Between Histopathology and Genomic Profiles for Survival Prediction Open
Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions. C…
View article: Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble
Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble Open
View article: Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance
Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance Open
Breast cancer is the most common malignancy among women worldwide, with drug therapy playing a crucial role in its treatment. In recent years, poly ADP-ribose polymerase (PARP) inhibitors, such as Olaparib, have shown significant efficacy …
View article: Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment
Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment Open
Pancreatic cancer remains one of the most lethal malignancies in the digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical need highlights the urgency to discover novel, highly efficient small…
View article: Hemodialysis pathway types influence wound healing complications and survival in end-stage renal disease patients in a retrospective cohort study
Hemodialysis pathway types influence wound healing complications and survival in end-stage renal disease patients in a retrospective cohort study Open
This study evaluates the impact of different hemodialysis access types—central venous catheter (CVC), arteriovenous graft (AVG), and autologous arteriovenous fistula (AVF)—on wound healing, complication rates, and long-term survival in pat…
View article: Exploratory Algorithms to Aid in Risk of Malignancy Prediction for Indeterminate Pulmonary Nodules
Exploratory Algorithms to Aid in Risk of Malignancy Prediction for Indeterminate Pulmonary Nodules Open
Background/Objectives: Lung cancer screening can reduce patient mortality. Multiple issues persist including timely management of patients with a radiologically defined indeterminate pulmonary nodule (IPN), which carries unknown pathologic…
View article: Optimizing a Patient-Centered Report of Somatic and Germline Genetic Test Results
Optimizing a Patient-Centered Report of Somatic and Germline Genetic Test Results Open