James E. Crowe
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View article: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity Open
HIV-1 continues to pose a significant global health challenge, requiring ongoing research into effective prevention and treatment strategies. Understanding the B-cell repertoire that can be engaged upon vaccination in humans is crucial for…
View article: Human coronavirus HKU1 neutralization by glycan receptor mimicry
Human coronavirus HKU1 neutralization by glycan receptor mimicry Open
Summary Entry of seasonal human coronavirus HKU1 (HCoV-HKU1) into host cells is facilitated by sequential binding to sialoglycans and transmembrane serine protease 2 (TMPRSS2) receptors. However, the neutralizing capacity of antibodies dis…
View article: Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice
Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice Open
Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1, subsequent Omicron sub-lineages have continued to emerge, challenging the development of intervention and prevention strategies, including monoclonal anti…
View article: The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation
The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation Open
The approval for a respiratory syncytial virus (RSV) maternal vaccination programme by Gavi, The Vaccine Alliance, marks substantial progress toward equitable access, with important work still to come. Several countries, most of which are …
View article: Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants
Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants Open
Dengue virus (DENV) consists of four serotypes (DENV1-4). Current vaccines induce differing levels of immune response against the four serotypes, that might prime recipients to develop severe disease in subsequent infections. Several DENV …
View article: Mature dengue virus particles inactivated by a non-ionic detergent retain quaternary neutralizing epitopes and induce potent neutralizing antibodies
Mature dengue virus particles inactivated by a non-ionic detergent retain quaternary neutralizing epitopes and induce potent neutralizing antibodies Open
Introduction The four serotypes of dengue virus (DENV1-4) are the leading cause of arboviral diseases in humans. Currently, developing a safe and effective DENV vaccine remains a challenge. Previously we reported potently neutralizing huma…
View article: Corrigendum to Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface
Corrigendum to Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface Open
View article: Mouse Adapted Omicron BA.5 Induces A Fibrotic Lung Disease Phenotype in BALB/c Mice.
Mouse Adapted Omicron BA.5 Induces A Fibrotic Lung Disease Phenotype in BALB/c Mice. Open
Following SARS-CoV-2 Omicron BA.1, subsequent Omicron sub-lineages have continued to emerge, challenging the development of intervention and prevention strategies, including monoclonal antibodies and vaccines. To better understand the path…
View article: Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors
Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors Open
The sudden rise of the SARS-CoV-2 virus and the delay in development of effective therapeutics for mitigation made evident a need for ways to screen compounds that can block infection and prevent further pathogenesis and spread. However, i…
View article: The os subfibulare: the not so normal variant
The os subfibulare: the not so normal variant Open
Objective: The os subfibulare is an accessory ossification center and it is controversial whether it is developmental or stigmata from prior trauma. The purpose of this descriptive study is to demonstrate that prior ankle trauma is the und…
View article: Functional and antigenic landscape of the Nipah virus receptor-binding protein
Functional and antigenic landscape of the Nipah virus receptor-binding protein Open
Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here, we use deep mutational scanning to me…
View article: Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus Open
Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young child…
View article: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity Open
HIV-1 continues to pose a significant global health challenge, requiring ongoing research into effective prevention and treatment strategies. Understanding the B cell repertoire that can be engaged upon vaccination in humans is crucial for…
View article: Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen Open
View article: Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques
Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques Open
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused a global pandemic in 2016–2017 with continued ongoing transmission at low levels in several countries. In the absence of an approved ZIKV vaccine, neutralizing monoclonal antibod…
View article: A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein Open
Human respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are frequent drivers of morbidity and mortality in susceptible populations, most often infantile, older adults, and immunocompromised. The primary target of neutraliz…
View article: Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors
Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors Open
The sudden rise of the SARS-CoV-2 virus and the delay in the development of effective therapeutics to mitigate it made evident a need for ways to screen for compounds that can block infection and prevent further pathogenesis and spread. Ye…
View article: Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen Open
An efficacious universal influenza vaccine remains a long-sought goal for human health as current vaccines suffer from shortfalls such as mid to low efficacy and the need for yearly revisions in strains use to account for viral drift/shift…
View article: Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques
Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques Open
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused a global pandemic in 2016-2017 with continued ongoing transmission at low levels in several countries. In the absence of an approved ZIKV vaccine, neutralizing monoclonal antibod…
View article: Author Correction: Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system
Author Correction: Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system Open
complement" but should have been "Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system".
View article: Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine
Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine Open
The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice imm…
View article: Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system
Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system Open
Antibodies to Ebola virus glycoprotein (EBOV GP) represent an important correlate of the vaccine efficiency and infection survival. Both neutralization and some of the Fc-mediated effects are known to contribute the protection conferred by…
View article: Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection
Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection Open
Cellular and molecular characterization of immune responses elicited by influenza virus infection and seasonal vaccination have informed efforts to improve vaccine efficacy, breadth, and longevity. Here, we use negative stain electron micr…
View article: Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines Open
View article: Computationally restoring the potency of a clinical antibody against Omicron
Computationally restoring the potency of a clinical antibody against Omicron Open
View article: Functional and antigenic landscape of the Nipah virus receptor binding protein
Functional and antigenic landscape of the Nipah virus receptor binding protein Open
Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here we use deep mutational scanning to mea…
View article: Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses.
Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses. Open
View article: Transient Generalized Osteosclerosis in a Newborn Mimicking Congenital Osteopetrosis with Negative Comprehensive Genetic Workup: A Case Report
Transient Generalized Osteosclerosis in a Newborn Mimicking Congenital Osteopetrosis with Negative Comprehensive Genetic Workup: A Case Report Open
We present a newborn with transient generalized osteosclerosis and negative genetic workup. The etiology of this condition is unknown. Given overlapping radiologic signs with severe forms of osteopetrosis, familiarity with this condition i…
View article: Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody
Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody Open
SUMMARY/ABSTRACT Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus intervention…
View article: Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boosting
Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boosting Open
Immune imprinting is a phenomenon in which an individual’s prior antigenic experiences influence responses to subsequent infection or vaccination. Here, using antibody depletion and multiplexed spike-binding assays, we characterized the ty…