James E. Saunders
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View article: The <i>TECTB-C225Y</i> Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice
The <i>TECTB-C225Y</i> Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice Open
Identifying new genes responsible for non-syndromic hearing loss remains a critical goal, as many individuals with hereditary deafness still lack a molecular diagnosis despite comprehensive genetic testing. The tectorial membrane (TM) is a…
View article: International Consensus Statements on Intraoperative Testing for Cochlear Implantation Surgery
International Consensus Statements on Intraoperative Testing for Cochlear Implantation Surgery Open
Objectives: A wide variety of intraoperative tests are available in cochlear implantation. However, no consensus exists on which tests constitute the minimum necessary battery. We assembled an international panel of clinical experts to dev…
View article: Priorities for hearing loss prevention and estimates of global cause-specific burdens of hearing loss: a systematic rapid review
Priorities for hearing loss prevention and estimates of global cause-specific burdens of hearing loss: a systematic rapid review Open
The US National Institute on Deafness and Other Communication Disorders and the US National Institute on Aging.
View article: Assessment of Central Auditory Processing in Children Using a Novel Tablet-Based Platform: Application for Low- and Middle-Income Countries
Assessment of Central Auditory Processing in Children Using a Novel Tablet-Based Platform: Application for Low- and Middle-Income Countries Open
Objective Evaluate whether a portable, tablet-based central auditory processing (CAP) test system using native language training videos and administered by minimally trained community health workers can produce CAP results comparable to pr…
View article: An analysis of the inclusion of ear and hearing care in national health policies, strategies and plans
An analysis of the inclusion of ear and hearing care in national health policies, strategies and plans Open
Ear- and hearing-related conditions pose a significant global health burden, yet public health policy surrounding ear and hearing care (EHC) in low- and middle-income countries is poorly understood. The present study aims to characterize t…
View article: Povidone-Iodine Fails to Eradicate Chronic Suppurative Otitis Media and Demonstrates Ototoxic Risk in Mice
Povidone-Iodine Fails to Eradicate Chronic Suppurative Otitis Media and Demonstrates Ototoxic Risk in Mice Open
Hypothesis Commercially available povidone-iodine solution can eliminate biofilms and persister cells rapidly in in vivo achievable concentrations without inducing ototoxicity. Background Chronic suppurative otitis media (CSOM) is a substa…
View article: Community health workers and mHealth systems for hearing screening in rural Nicaraguan schoolchildren
Community health workers and mHealth systems for hearing screening in rural Nicaraguan schoolchildren Open
Tablet-based hearing screening administered by minimally trained CHWs is feasible and effective in low- and middle-income countries. Manual audiometry was as efficient as automated audiometry in this setting. The physical exam tasks of oto…
View article: Validation of the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL) in Chile, India, and Nigeria
Validation of the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL) in Chile, India, and Nigeria Open
National Institutes of Health (3UL1-TR002553-03S3 and F30 DC019846).
View article: The predictive power of geographic health care utilization for unintentional fatal fall rates
The predictive power of geographic health care utilization for unintentional fatal fall rates Open
Background Falls are the leading cause of fatal and nonfatal injuries among adults over 65 years old. The increase in fall mortality rates is likely multifactorial. With a lack of key drivers identified to explain rising rates of death fro…
View article: Development and validation of DeciBHAL-US: A novel microsimulation model of hearing loss across the lifespan in the United States
Development and validation of DeciBHAL-US: A novel microsimulation model of hearing loss across the lifespan in the United States Open
This study was funded by the National Institute on Deafness and Other Communication Disorders and the National Institute on Aging (3UL1-TR002553-03S3 and F30 DC019846).
View article: The Predictive Power of State-Level Health Care Utilization for Unintentional Fatal Fall Rates
The Predictive Power of State-Level Health Care Utilization for Unintentional Fatal Fall Rates Open
ObjectiveTo examine the predictive power of state-level care utilization and longitudinal trends in mortality from unintentional falls amongst different demographic and geographic strata.Study DesignNationwide, retrospective cohort study.S…
View article: Perceptions of Sound Quality and Enjoyment After Cochlear Implantation
Perceptions of Sound Quality and Enjoyment After Cochlear Implantation Open
Objectives To characterize the quality and enjoyment of sound by cochlear implant (CI) recipients and identify predictors of these outcomes after cochlear implantation. Study Design Cross‐sectional study. Setting A tertiary care hospital. …
View article: Outcomes of a novel alloplastic technique for external auditory canal repair in tympanomastoidectomy
Outcomes of a novel alloplastic technique for external auditory canal repair in tympanomastoidectomy Open
Objective To analyze surgical outcomes of a novel alloplastic reconstruction technique for partial external auditory canal (EAC) defects in tympanomastoidectomy. Methods Retrospective study of 51 patients with cholesteatoma who underwent r…
View article: Comparison of Transmastoid and Middle Fossa Approaches for Superior Canal Dehiscence Repair: A Multi‐institutional Study
Comparison of Transmastoid and Middle Fossa Approaches for Superior Canal Dehiscence Repair: A Multi‐institutional Study Open
Objective To compare outcomes for patients undergoing a transmastoid approach versus a middle fossa craniotomy approach with plugging and/or resurfacing for repair of superior semicircular canal dehiscence. Outcome measures include symptom…