James Geraghty
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View article: Fewer than 1 in 4 Australians work in a gender-balanced occupation. Fixing it is in all our interests
Fewer than 1 in 4 Australians work in a gender-balanced occupation. Fixing it is in all our interests Open
View article: A Qualitative Study to Understand the Barriers and Facilitators in Smoking Cessation Practices Among Oncology Health Care Practitioners in One Health System
A Qualitative Study to Understand the Barriers and Facilitators in Smoking Cessation Practices Among Oncology Health Care Practitioners in One Health System Open
Introduction Despite the benefits of quitting smoking for those who have cancer, including improved health outcomes and reduced therapeutic toxicities, it is unclear how many people are supported in quit attempts during this time. Variatio…
View article: Invasive lobular carcinoma of the breast; clinicopathologic profile and response to neoadjuvant chemotherapy over a 15-year period
Invasive lobular carcinoma of the breast; clinicopathologic profile and response to neoadjuvant chemotherapy over a 15-year period Open
Atypical ILCs have distinct characteristics. They are more frequently of a higher grade and demonstrate a superior response to NACT. Despite the latter, atypical ILCs have a worse 5-year DFS which should be taken into consideration in term…
View article: Real-World Analysis of the Clinical and Economic Impact of the 21-Gene Recurrence Score (RS) in Invasive Lobular Early-Stage Breast Carcinoma in Ireland
Real-World Analysis of the Clinical and Economic Impact of the 21-Gene Recurrence Score (RS) in Invasive Lobular Early-Stage Breast Carcinoma in Ireland Open
Background: This study, using real-world data, assesses the impact of RS testing on treatment pathways and the associated economic consequences of such testing. This paper pertains to lobular breast cancer. Methods: A retrospective, observ…
View article: Letter to the Editor: Recognizing patient harm through inclusive study recruitment
Letter to the Editor: Recognizing patient harm through inclusive study recruitment Open
In March 2023, Ledger et al. published a paper entitled Patient perceptions and understanding of pressure ulcer (PU) risk in the community: Empirical Research Qualitative. This study aimed to explore patient perceptions and understanding o…
View article: Nodal positivity in patients with clinically and radiologically node-negative breast cancer treated with neoadjuvant chemotherapy: multicentre collaborative study
Nodal positivity in patients with clinically and radiologically node-negative breast cancer treated with neoadjuvant chemotherapy: multicentre collaborative study Open
Background The necessity of performing a sentinel lymph node biopsy in patients with clinically and radiologically node-negative breast cancer after neoadjuvant chemotherapy has been questioned. The aim of this study was to determine the r…
View article: Correlation between the Clinical Treatment Score Post 5 years (CTS5) and the Oncotype DX 21-gene recurrence score (ODX-RS); can we accurately predict patients who require extended adjuvant hormonal manipulation.
Correlation between the Clinical Treatment Score Post 5 years (CTS5) and the Oncotype DX 21-gene recurrence score (ODX-RS); can we accurately predict patients who require extended adjuvant hormonal manipulation. Open
Background . While hormone receptor-positive (HR+), HER 2-negative (HER2-), node-negative breast cancer is associated with an excellent overall prognosis, it possesses a unique penchant for late recurrence. Estimating breast cancer recurre…
View article: The association between breast density and breast cancer pathological response to neoadjuvant chemotherapy
The association between breast density and breast cancer pathological response to neoadjuvant chemotherapy Open
View article: AB011. SOH22ABS170. Incidence of treatment effect in patients with an axillary pathologic complete response after neoadjuvant chemotherapy for breast cancer
AB011. SOH22ABS170. Incidence of treatment effect in patients with an axillary pathologic complete response after neoadjuvant chemotherapy for breast cancer Open
Background: De-escalation of axillary surgery following neoadjuvant chemotherapy (NACT) for patients with node positive disease at diagnosis have focused on ensuring a low false negative rate for those who undergo sentinel lymph node biops…
View article: AB171. SOH22ABS198. Has the coronavirus disease (COVID) pandemic resulted in delayed presentations in in elderly patients with breast cancer?
AB171. SOH22ABS198. Has the coronavirus disease (COVID) pandemic resulted in delayed presentations in in elderly patients with breast cancer? Open
Background: The pressure on the Irish healthcare system imparted by the coronavirus disease 2019 (COVID-19) pandemic has raised concerns that related care delays will result in excess cancer-related deaths. Studies of non-oncology, chronic…
View article: AB005. SOH22ABS117. Prospective evaluation of the 2021 National Cancer Control Program (NCCP) mammogram only pathway
AB005. SOH22ABS117. Prospective evaluation of the 2021 National Cancer Control Program (NCCP) mammogram only pathway Open
Background: Referral numbers to symptomatic breast clinics in Ireland continue to increase. In April 2021, the National Cancer Control Program (NCCP) launched a new symptomatic breast referral guideline. This included a ‘Mammogram Only’ st…
View article: AB007. SOH22ABS130. The role of routine sentinel lymph node biopsy in elderly patients with breast cancer
AB007. SOH22ABS130. The role of routine sentinel lymph node biopsy in elderly patients with breast cancer Open
Background: Recent guidelines from the Society of Surgical Oncology recommended against the routine use of sentinel lymph biopsy (SLN) in women over the age of 70 years with pT1 ER-positive breast cancer. The aim of this study was to evalu…
View article: AB010. SOH22ABS169. De-escalation of axillary surgery post neoadjuvant therapy in hormone-positive breast cancer: feasible or futile
AB010. SOH22ABS169. De-escalation of axillary surgery post neoadjuvant therapy in hormone-positive breast cancer: feasible or futile Open
Background: A proportion of patients with breast cancer presenting with nodal metastases will undergo an axillary pathological complete response (pCR) following neoadjuvant chemotherapy (NACT). The probability of an axillary pCR is highly …
View article: Fertility treatment and breast-cancer incidence: meta-analysis
Fertility treatment and breast-cancer incidence: meta-analysis Open
Background The significance of exogenous hormone manipulation as part of fertility treatment and its relationship to the development of breast cancer remains uncertain. Several historical reviews have been performed with conflicting result…
View article: EP.TH.930Contemporary trends in the management of micrometastatic axillary disease in the setting of mastectomy – a 5 year single institution experience
EP.TH.930Contemporary trends in the management of micrometastatic axillary disease in the setting of mastectomy – a 5 year single institution experience Open
Background Since the ACOSOG Z0011 trial, rates of axillary node clearance (ANC) for micrometastatic axillary disease have declined among women undergoing breast conservation surgery (BCS). However, for women undergoing mastectomy, it remai…
View article: AB010. SOH21AS220. Comparison of outcomes between immediate direct-to-implant breast reconstruction versus two-stage implant breast reconstruction: a systematic review and meta-analysis
AB010. SOH21AS220. Comparison of outcomes between immediate direct-to-implant breast reconstruction versus two-stage implant breast reconstruction: a systematic review and meta-analysis Open
Background: Direct-to-implant (DTI) breast reconstruction is increasingly performed as the preferred method of immediate breast reconstruction following mastectomy. The proposed advantages of DTI over two-stage tissue expander (TE)/implant…
View article: AB056. SOH21AS189. The CTS5 score as a predictor of late distant recurrence: a systematic review and meta-analysis
AB056. SOH21AS189. The CTS5 score as a predictor of late distant recurrence: a systematic review and meta-analysis Open
Background: The Clinical Treatment Score post-5 years (CTS5) integrates four clinicopathologic variables to estimate the residual disease recurrence risk in estrogen receptor-positive (ER+) breast cancer patients who have been treated with…
View article: AB002. SOH21AS038. Optimal timing of surgery following breast cancer neoadjuvant chemotherapy: a systematic review and meta-analysis
AB002. SOH21AS038. Optimal timing of surgery following breast cancer neoadjuvant chemotherapy: a systematic review and meta-analysis Open
Background: The indications for neoadjuvant breast cancer treatment have expanded rapidly in recent decades. Administration of chemotherapy before surgery has the potential to reduce the risk of distant recurrence by targeting circulating …
View article: AB193. SOH21AS245. Atypical invasive lobular carcinoma of the breast: clinicopathologic profile and outcomes over a 10-year period
AB193. SOH21AS245. Atypical invasive lobular carcinoma of the breast: clinicopathologic profile and outcomes over a 10-year period Open
Background: Invasive lobular carcinoma (ILC) accounts for 10–15% of invasive breast cancers. Typical ILC is estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER2) negative. Atypical lobular subtypes appear to d…
View article: O79: THE ROLE OF SENTINEL LYMPH NODE BIOPSY IN BREAST CANCER PATIENTS OVER THE AGE OF 80 – HOW MUCH IS ENOUGH?
O79: THE ROLE OF SENTINEL LYMPH NODE BIOPSY IN BREAST CANCER PATIENTS OVER THE AGE OF 80 – HOW MUCH IS ENOUGH? Open
Introduction Recent studies have suggested that sentinel lymph node biopsy (SLNB) can be omitted in newly diagnosed elderly breast cancer (BC) patients as it may not influence decisions regarding further therapeutic intervention. The aim o…
View article: AB028. Assessing the oncotype dx breast recurrence score assay on core biopsy to predict response to neoadjuvant treatment in patients with breast cancer—a systematic review and meta-analysis
AB028. Assessing the oncotype dx breast recurrence score assay on core biopsy to predict response to neoadjuvant treatment in patients with breast cancer—a systematic review and meta-analysis Open
Background: The Oncotype DX breast recurrence score (RS) has been validated to predict the benefits of adjuvant chemotherapy in patients with estrogen receptor (ER)-positive, HER2-negative breast cancer. The use of RS assessment for predic…
View article: AB025. The role of sentinel lymph node biopsy in breast cancer patients over the age of 80—how much is enough?
AB025. The role of sentinel lymph node biopsy in breast cancer patients over the age of 80—how much is enough? Open
Background: Recent studies have suggested that sentinel lymph node biopsy (SLNB) can be omitted in newly diagnosed elderly breast cancer (BC) patients as it may not influence decisions regarding further therapeutic intervention. The aim of…
View article: AB026. Does post-operative morbidity affect oncological outcomes in breast cancer patients undergoing mastectomy and reconstruction?—a systematic review and meta-analysis
AB026. Does post-operative morbidity affect oncological outcomes in breast cancer patients undergoing mastectomy and reconstruction?—a systematic review and meta-analysis Open
View article: AB027. A systematic review and meta-analysis of the utility of lymphoscintigraphy in the management of clinically node-negative breast cancer
AB027. A systematic review and meta-analysis of the utility of lymphoscintigraphy in the management of clinically node-negative breast cancer Open
Background: This systematic review aimed to determine if preoperative lymphoscintigraphy (LSG) enhances the sentinel node identification rate in clinically node-negative breast cancer and evaluate if LSG affects the false negative rate of …
View article: The approach to an isolated close anterior margin in breast conserving surgery
The approach to an isolated close anterior margin in breast conserving surgery Open
Introduction Although close radial margins after breast-conserving surgery routinely undergo re-excision, appropriate management of patients with close anterior margins remains a topic of controversy. An increasing body of literature sugge…
View article: AB016. 114. Yield from systemic staging of breast cancer patients following a positive sentinel node biopsy
AB016. 114. Yield from systemic staging of breast cancer patients following a positive sentinel node biopsy Open
Background: The prognostic significance of axillary lymph node metastases in patients with breast cancer has long been established. Despite advances in the molecular profiling of breast cancers, nodal status remains an important determinan…
View article: AB021. 189. The incidence of breast carcinoma recurrence post breast conserving surgery
AB021. 189. The incidence of breast carcinoma recurrence post breast conserving surgery Open
Background: Since the adoption of breast conserving therapy (BCT) in suitable patients with breast cancer, concerns over local recurrence rates have remained. Surveillance of patients following BCT will inherently involve a rate of ipsilat…
View article: Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project
Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project Open
Initiating trastuzumab more than 12 weeks from diagnosis has a negative impact on clinical outcome. Neo-adjuvant anti-HER2 therapy could be the optimal strategy to treat early stage HER2-positive breast cancer.
View article: AB050. 9. Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breast cancer: a systematic review and meta-analysis
AB050. 9. Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breast cancer: a systematic review and meta-analysis Open
Background: Neoadjuvant chemotherapy (NAC) for breast cancer has the potential to achieve pathological complete response (pCR) in up to 40% of patients, rendering patients who were initially node-positive to node-negative. This raised the …
View article: AB195. 194. Clinicopathological features and management of metaplastic breast cancer: a single institution experience
AB195. 194. Clinicopathological features and management of metaplastic breast cancer: a single institution experience Open
Background: Metaplastic breast carcinoma (MBC) is a rare heterogenous histopathological subtype of primary breast carcinoma arising from both epithelial and mesenchymal elements. It accounts for <1% of all breast malignancies. MBC has poor…