James Heaf
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View article: Differences in association between hypoalbuminaemia and mortality among younger versus older patients on haemodialysis
Differences in association between hypoalbuminaemia and mortality among younger versus older patients on haemodialysis Open
Background Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum albumin <4.0 g/dl. This …
View article: Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients
Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients Open
Background Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease–mineral and bone disorders (CKD-MBD) and bone fr…
View article: Far infrared treatment on the arteriovenous fistula induces changes in sVCAM and sICAM in patients on hemodialysis
Far infrared treatment on the arteriovenous fistula induces changes in sVCAM and sICAM in patients on hemodialysis Open
Introduction There is a substantial risk of developing stenosis and dysfunction in the arteriovenous fistula (AVF) in patients on hemodialysis (HD). Far infrared radiation (FIR) is a non-invasive local intervention with a potentially benef…
View article: Rate and Risk Factors of Acute Myocardial Infarction after Debut of Chronic Kidney Disease—Results from the KidDiCo
Rate and Risk Factors of Acute Myocardial Infarction after Debut of Chronic Kidney Disease—Results from the KidDiCo Open
Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease, including acute myocardial infarction. However, whether this risk is only associated with severe kidney disease or is also related to mildly impaired kidney fu…
View article: Referral rate of chronic kidney disease patients to a nephrologist in the Region of Southern Denmark: results from KidDiCo
Referral rate of chronic kidney disease patients to a nephrologist in the Region of Southern Denmark: results from KidDiCo Open
Background Data on the referral rate of chronic kidney disease (CKD) patients to specialists are sparse. Investigating referral rates and characterizing patients with kidney disease not followed by a nephrologist are relevant for future me…
View article: Bayesian parameter estimation for phosphate dynamics during hemodialysis
Bayesian parameter estimation for phosphate dynamics during hemodialysis Open
Hyperphosphatemia in patients with renal failure is associated with increased vascular calcification and mortality. Hemodialysis is a conventional treatment for patients with hyperphosphatemia. Phosphate kinetics during hemodialysis may be…
View article: MO742: The Influence of Haemodialysis on Ultra-Sensitive and High Sensitive Troponin I—A Systematic Review
MO742: The Influence of Haemodialysis on Ultra-Sensitive and High Sensitive Troponin I—A Systematic Review Open
BACKGROUND AND AIMS Troponin is the preferred biomarker for diagnosing acute myocardial infarction (AMI). The new generations of high-sensitive troponin (hs-cTnI) assays are now the most commonly used including ultra-sensitive assays. If, …
View article: Troponin Cut-Offs for Acute Myocardial Infarction in Patients with Impaired Renal Function—A Systematic Review and Meta-Analysis
Troponin Cut-Offs for Acute Myocardial Infarction in Patients with Impaired Renal Function—A Systematic Review and Meta-Analysis Open
Identifying acute myocardial infarction in patients with renal disease is notoriously difficult, due to atypical presentation and chronically elevated troponin. The aim of this study was to identify a specific troponin T/troponin I cut-off…
View article: Bayesian parameter estimation for phosphate dynamics during hemodialysis
Bayesian parameter estimation for phosphate dynamics during hemodialysis Open
Hyperphosphatemia in patients with renal failure is associated with increased vascular calcification and mortality. Hemodialysis is a conventional treatment for patients with hyperphosphatemia. Phosphate kinetics during hemodialysis may be…
View article: Association of Prescription With Body Composition and Patient Outcomes in Incident Peritoneal Dialysis Patients
Association of Prescription With Body Composition and Patient Outcomes in Incident Peritoneal Dialysis Patients Open
Objective: The nutritional status of patients on peritoneal dialysis (PD) is influenced by patient- and disease-related factors and lifestyle. This analysis evaluated the association of PD prescription with body composition and patient out…
View article: Kidney Disease Cohort (KidDiCo) of Southern Denmark: Design, Coverage, Generalizability and Implications for Use
Kidney Disease Cohort (KidDiCo) of Southern Denmark: Design, Coverage, Generalizability and Implications for Use Open
Based on coverage of 78% together with similar characteristics in terms of gender and age, the KiDiCo is a representative cohort of patients in the Region of Southern Denmark. Combining laboratory data with high-quality Danish administrati…
View article: Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the FAITH on fistula trial
Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the FAITH on fistula trial Open
Background An arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis treatment. After creation many of the AVFs will never mature or if functioning will need an intervention within 1 year due to an AVF stenosis. Stud…
View article: First-year mortality in incident dialysis patients: results of the Peridialysis study
First-year mortality in incident dialysis patients: results of the Peridialysis study Open
Background : Controversy surrounds which factors are important for predicting early mortality after dialysis initiation (DI). We investigated associations of predialysis course and circumstances affecting planning and execution of DI with …
View article: Choice of dialysis modality among patients initiating dialysis: results of the Peridialysis study
Choice of dialysis modality among patients initiating dialysis: results of the Peridialysis study Open
Background In patients with end-stage kidney disease (ESKD), home dialysis offers socio-economic and health benefits compared with in-centre dialysis but is generally underutilized. We hypothesized that the pre-dialysis course and institut…
View article: Effect of comorbidities on survival in patients &gt;80 years of age at onset of renal replacement therapy: data from the ERA-EDTA Registry
Effect of comorbidities on survival in patients >80 years of age at onset of renal replacement therapy: data from the ERA-EDTA Registry Open
Background The number of elderly patients on renal replacement therapy (RRT) is increasing. The survival and quality of life of these patients may be lower if they have multiple comorbidities at the onset of RRT. The aim of this study was …
View article: The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA‐EDTA Registry – a retrospective study
The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA‐EDTA Registry – a retrospective study Open
In this study we aimed to compare patient and graft survival of kidney transplant recipients who received a kidney from a living-related donor (LRD) or living-unrelated donor (LUD). Adult patients in the ERA-EDTA Registry who received thei…
View article: Increased incidence and improved prognosis of glomerulonephritis: a national 30-year study
Increased incidence and improved prognosis of glomerulonephritis: a national 30-year study Open
Background While there are many cross-sectional studies of glomerulonephritis (GN) incidence, changes in incidence over time, particularly in the 21st century have received less attention. Similarly, little is known about temporal changes …
View article: P1448FACTORS ASSOCIATED WITH INCREASED MORTALITY AFTER DIALYSIS INITIATION. RESULTS OF THE PERIDIALYSIS STUDY
P1448FACTORS ASSOCIATED WITH INCREASED MORTALITY AFTER DIALYSIS INITIATION. RESULTS OF THE PERIDIALYSIS STUDY Open
Background and Aims Home dialysis with peritoneal dialysis (PD) or home hemodialysis (HD) has medical and socioeconomic benefits but home dialysis is generally underutilized. While many factors determine choice of initial dialysis modality…
View article: Suboptimal dialysis initiation is associated with comorbidities and uraemia progression rate but not with estimated glomerular filtration rate
Suboptimal dialysis initiation is associated with comorbidities and uraemia progression rate but not with estimated glomerular filtration rate Open
Background Despite early referral of uraemic patients to nephrological care, suboptimal dialysis initiation (SDI) remains a common problem associated with increased morbimortality. We hypothesized that SDI is related to pre-dialysis care. …
View article: Non-medical barriers reported by nephrologists when providing renal replacement therapy or comprehensive conservative management to end-stage kidney disease patients: a systematic review
Non-medical barriers reported by nephrologists when providing renal replacement therapy or comprehensive conservative management to end-stage kidney disease patients: a systematic review Open
Background Large international differences exist in access to renal replacement therapy (RRT) modalities and comprehensive conservative management (CCM) for patients with end-stage kidney disease (ESKD), suggesting that some patients are n…
View article: The impact of volume overload on technique failure in incident peritoneal dialysis patients
The impact of volume overload on technique failure in incident peritoneal dialysis patients Open
Background Technique failure in peritoneal dialysis (PD) can be due to patient- and procedure-related factors. With this analysis, we investigated the association of volume overload at the start and during the early phase of PD and techniq…
View article: Hypertensive nephropathy is associated with an increased risk of myeloma, skin, and renal cancer
Hypertensive nephropathy is associated with an increased risk of myeloma, skin, and renal cancer Open
Previous studies suggest an increased cancer risk in hypertension. Patients with hypertensive nephropathy have not been studied. A national registry study was performed to assess the presence and size of this association. Clinical data and…
View article: Evolution Over Time of Volume Status and PD-Related Practice Patterns in an Incident Peritoneal Dialysis Cohort
Evolution Over Time of Volume Status and PD-Related Practice Patterns in an Incident Peritoneal Dialysis Cohort Open
Background and objectives Volume overload is frequent in prevalent patients on kidney replacement therapies and is associated with outcome. This study was devised to follow-up volume status of an incident population on peritoneal dialysis …