Martin J. Humphries
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View article: Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells
Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells Open
Background Atherosclerosis develops at arterial sites exposed to disturbed flow, while plaque rupture and plaque erosion predominantly occur in regions subjected to elevated flow. The impact of elevated flow on regulation of endothelial ge…
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines
Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines Open
Integrins bind to extracellular matrix proteins and, upon clustering, form multimolecular integrin adhesion complexes (IACs) that connect to and regulate the cell cytoskeleton, influencing various aspects of normal and tumour cell behaviou…
View article: The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing
The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing Open
Cilia function in the left-right organizer (LRO) is critical for determining internal organ asymmetry in vertebrates. To further understand the genetics of left-right asymmetry, we isolated a mouse mutant with laterality defects, l11Jus27,…
View article: Inhibitory TIGIT signalling is dependent on T cell receptor activation
Inhibitory TIGIT signalling is dependent on T cell receptor activation Open
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cells remain poorly defined, and it is not …
View article: Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit
Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit Open
Our overarching aim was to determine how hypoxia affects the extracellular matrix (ECM). Transcriptomic analysis (21,941 patients; 10 cancer types) identified ECM remodelling as the predominant pathway affected by hypoxia. Multi-omics conf…
View article: A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration Open
SUMMARY Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin-based lamellipodia protrusions, powered by actin polymerizati…
View article: KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism
KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism Open
Background Integrins form focal adhesions (FAs) at the cell edge and fibrillar adhesions (FBs) located centrally. Talin 1 is essential to FAs, while talin2 is found in FAs and FBs. KANK (kidney ankyrin repeat-containing) family proteins re…
View article: The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells Open
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145 PC model to conduct a…
View article: Abstract 1812 Vinculin Expression and Substrate Stiffness Regulate Proliferation, Activin-A Secretion and Mechanosensory Gene Expression in Mesenchymal Stem Cells
Abstract 1812 Vinculin Expression and Substrate Stiffness Regulate Proliferation, Activin-A Secretion and Mechanosensory Gene Expression in Mesenchymal Stem Cells Open
Mesenchymal stem cells (MSCs) are multipotent fibroblast-like stem cells that can differentiate into muscle, bone, cartilage and fat cells. In response to injury, MSCs home to wounded tissue and secrete growth factors, cytokines, extracell…
View article: Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Open
CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has inherent ability to promote wound healing: wounds close and re-epithelialise faster in CAR-tre…
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Correction: The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex
Correction: The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex Open
The authors wish to make readers aware of possible errors in J. Cell Sci. (2017) 130, jcs200329 (doi:10.1242/jcs.200329).In early 2023, the authors sent the GFP–Sharpin plasmids used in the article for deposition at Addgene. Next-generatio…
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line
Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line Open
Background Focal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways that control cell proliferation, differentiation, survival…
View article: Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest Open
Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest lack mechanistic understanding. We previously showed that arterial shear stress up-regulates Cx37 in endothelial cells and activates a Notch/Cx37/p27 …
View article: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line
Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line Open
BackgroundFocal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways that control cell proliferation, differentiation, survival …
View article: A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion
A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion Open
Aims Endothelial erosion of plaques is responsible for ∼30% of acute coronary syndromes (ACS). Smoking is a risk factor for plaque erosion, which most frequently occurs on the upstream surface of plaques where the endothelium experiences e…
View article: The βI domain promotes active β1 integrin clustering into mature adhesion sites
The βI domain promotes active β1 integrin clustering into mature adhesion sites Open
Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. Integrin allosteric changes, clustering, and trafficking cooperate to regulate cell adhesion and motility on extr…
View article: Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry
Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry Open
Introduction Vasculogenic mimicry (VM), the process of tumor cell trans-differentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including smal…
View article: Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Open
CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has an inherent ability to promote wound healing; wounds close and re-epithelialise faster in CAR-…
View article: Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation
Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation Open
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together wit…