James I. Hearn
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View article: Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function
Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function Open
Clinical features in patients with the B-cell lymphoma, Waldenström macroglobulinemia (WM), include cytopenias, immunoglobulin M (IgM)–mediated hyperviscosity, fatigue, bleeding, and bruising. Therapeutics such as Bruton's tyrosine kinase …
View article: L-plastin associated syndrome of immune deficiency and hematologic cytopenia
L-plastin associated syndrome of immune deficiency and hematologic cytopenia Open
We describe a unique human hematopoietic defect affecting neutrophils, lymphocytes, and platelets arising from partial LCP1 deficiency.
View article: Is glycoprotein VI involved in contractual negotiations?
Is glycoprotein VI involved in contractual negotiations? Open
Glycoprotein (GP) VI is the primary signaling receptor for collagen and is found exclusively on platelets and megakaryocytes. GPVI engagement by exposed collagen within a damaged vascular space initiates thrombus formation, and subsequent …
View article: N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1
N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1 Open
Peripheral circadian clocks control cell proliferation and survival, but little is known about their role and regulation in megakaryocytic cells. N-methyl-D-aspartate receptor (NMDAR) regulates the central clock in the brain. The purpose o…
View article: N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1
N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1 Open
Peripheral circadian clocks control cell proliferation and survival, but little is known about their role and regulation in megakaryocytic cells. N-methyl-D-aspartate receptor (NMDAR) regulates the central clock in the brain. The purpose o…
View article: The Chondrogenic Potential of First-Trimester and Term Placental Mesenchymal Stem/Stromal Cells
The Chondrogenic Potential of First-Trimester and Term Placental Mesenchymal Stem/Stromal Cells Open
Objectives Mesenchymal stem/stromal cells (MSCs) are a well-established cell source for cartilage engineering, but challenges remain as differentiation often results in chondrocyte hypertrophy. Chondrogenic potential also varies with MSC s…
View article: N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?
N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned? Open
The N-methyl-D-aspartate receptor (NMDAR) provides a pathway for glutamate-mediated inter-cellular communication, best known for its role in the brain but with multiple examples of functionality in non-neuronal cells. Data previousl…
View article: N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation
N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation Open
The release of calcium ions (Ca2+) from the endoplasmic reticulum (ER) and related store-operated calcium entry (SOCE) regulate maturation of normal megakaryocytes. The N-methyl-D-aspartate (NMDA) receptor (NMDAR) provides an additional me…
View article: Micropatterned Growth Surface Topography Affects Extracellular Vesicle Production
Micropatterned Growth Surface Topography Affects Extracellular Vesicle Production Open
View article: Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes
Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes Open
View article: Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas
Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas Open
Merkel Cell Carcinoma (MCC) is a rare skin tumour with an incidence of 0.88 per 100,000 people in New Zealand (NZ), one of the highest in the world 1 and almost on par with close neighbours Australia 2 .Current local diagnostic guidelines …
View article: N‐methyl‐d‐aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines
N‐methyl‐d‐aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines Open
View article: Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis
Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis Open
GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence for relevance in peripheral tissues, including platelets. Certain anti-GluN1 antibodies …
View article: Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis
Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis Open
GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence for relevance in peripheral tissues, including platelets. Certain anti-GluN1 antibodies …
View article: A novel EGR‐1 dependent mechanism for YB‐1 modulation of paclitaxel response in a triple negative breast cancer cell line
A novel EGR‐1 dependent mechanism for YB‐1 modulation of paclitaxel response in a triple negative breast cancer cell line Open
Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a prop…