James I. MacDonald
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View article: Your Blood is Out for Delivery: Considerations of Shipping Time and Temperature on Degradation of RNA from Stabilized Whole Blood
Your Blood is Out for Delivery: Considerations of Shipping Time and Temperature on Degradation of RNA from Stabilized Whole Blood Open
Remote research studies are an invaluable tool for reaching populations with limited access to large medical centers or universities. To expand the remote study toolkit, we previously developed homeRNA, which allows for at-home self-collec…
View article: Your Blood is Out for Delivery: Considerations of Shipping Time and Temperature on Degradation of RNA from Stabilized Whole Blood
Your Blood is Out for Delivery: Considerations of Shipping Time and Temperature on Degradation of RNA from Stabilized Whole Blood Open
Remote research studies are an invaluable tool for reaching populations in geographical regions with limited access to large medical centers or universities. To expand the remote study toolkit, we have previously developed homeRNA, which a…
View article: Author response: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Author response: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
View article: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Author response: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Author response: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Joint Public Review: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Joint Public Review: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We utilized a susp…
View article: Reviewer #1 (Public Review): Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Reviewer #1 (Public Review): Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We utilized a susp…
View article: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Reviewer #2 (Public Review): Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Reviewer #2 (Public Review): Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We utilized a susp…
View article: Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells Open
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspe…
View article: Data from A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy
Data from A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy Open
Epithelial ovarian cancer (EOC) generates multicellular aggregates called spheroids that detach from the primary tumor and disseminate through ascites. Spheroids possess a number of characteristics of tumor dormancy including withdrawal fr…
View article: Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination
Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination Open
Multivalent presentation of ligands often enhances receptor activation and downstream signaling. DNA origami offers precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanoparticles. Here we introduce a “squa…
View article: Single-molecule mechanical fingerprinting with DNA nanoswitch calipers
Single-molecule mechanical fingerprinting with DNA nanoswitch calipers Open
View article: Phosphorylation of the RB C-terminus regulates condensin II release from chromatin
Phosphorylation of the RB C-terminus regulates condensin II release from chromatin Open
The retinoblastoma tumor suppressor protein (RB) plays an important role in biological processes such as cell cycle control, DNA damage repair, epigenetic regulation, and genome stability. The canonical model of RB regulation is that cycli…
View article: Phosphorylation of the RB C-terminus regulates condensin II release from chromatin
Phosphorylation of the RB C-terminus regulates condensin II release from chromatin Open
The retinoblastoma tumour suppressor protein (RB) plays an important role in biological processes such as cell cycle control, DNA damage repair, epigenetic regulation, and genome stability. The canonical model of RB regulation is that cycl…
View article: Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells
Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells Open
Macropinocytosis is a normal cellular process by which cells internalize extracellular fluids and nutrients from their environment and is one strategy that Ras-transformed pancreatic cancer cells use to increase uptake of amino acids to me…
View article: Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling
Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling Open
Silymarin, a characterized extract of the seeds of milk thistle (Silybum marianum), suppresses cellular inflammation. To define how this occurs, transcriptional profiling, metabolomics, and signaling studies were performed in human liver a…