James Knierim
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View article: Landmark Vector Cells in the Absence of Visual Input
Landmark Vector Cells in the Absence of Visual Input Open
View article: Explicit error coding can mediate gain recalibration in continuous bump attractor networks
Explicit error coding can mediate gain recalibration in continuous bump attractor networks Open
View article: Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells
Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells Open
Accurate spatial navigation relies on path integration, a process of tracking one’s location by integrating self-motion cues. Path integration uses a gain factor relating self-motion signals to displacement on the cognitive map. This gain …
View article: Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1
Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1 Open
The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatiotemporal framework encoding the location and temporal context of that experience. Previous work implies a distincti…
View article: Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model
Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model Open
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 perform a pattern completion or error co…
View article: Author response: Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1
Author response: Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1 Open
View article: Vector coding and place coding in hippocampus share a common directional signal
Vector coding and place coding in hippocampus share a common directional signal Open
View article: Multiplexing of temporal and spatial information in the lateral entorhinal cortex
Multiplexing of temporal and spatial information in the lateral entorhinal cortex Open
View article: Control and recalibration of path integration in place cells using optic flow
Control and recalibration of path integration in place cells using optic flow Open
View article: Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration
Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration Open
Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad rang…
View article: Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration
Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration Open
Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad rang…
View article: Multiplexing of temporal and spatial information in the lateral entorhinal cortex
Multiplexing of temporal and spatial information in the lateral entorhinal cortex Open
Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the specific mechanism by which LEC integrates spat…
View article: Object‐place‐context learning impairment correlates with spatial learning impairment in aged<scp>Long–Evans</scp>rats
Object‐place‐context learning impairment correlates with spatial learning impairment in aged<span>Long–Evans</span>rats Open
The hippocampal formation is vulnerable to the process of normal aging. In humans, the extent of this age‐related deterioration varies among individuals. Long–Evans rats replicate these individual differences as they age, and therefore the…
View article: Assessments of dentate gyrus function: discoveries and debates
Assessments of dentate gyrus function: discoveries and debates Open
View article: Conjunctive vector coding and place coding in hippocampus share a common directional signal
Conjunctive vector coding and place coding in hippocampus share a common directional signal Open
Vector coding is becoming increasingly understood as a major mechanism by which neural systems represent an animal’s location in both a global reference frame and a local, item-based reference frame. Landmark vector cells (LVCs) in the hip…
View article: Global remapping in granule cells and mossy cells of the mouse dentate gyrus
Global remapping in granule cells and mossy cells of the mouse dentate gyrus Open
Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, the dentate gyrus (DG) has two excitatory population…
View article: Superficial‐layer versus deep‐layer lateral entorhinal cortex: Coding of allocentric space, egocentric space, speed, boundaries, and corners
Superficial‐layer versus deep‐layer lateral entorhinal cortex: Coding of allocentric space, egocentric space, speed, boundaries, and corners Open
Entorhinal cortex is the major gateway between the neocortex and the hippocampus and thus plays an essential role in subserving episodic memory and spatial navigation. It can be divided into the medial entorhinal cortex (MEC) and the later…
View article: Global remapping in granule cells and mossy cells of the mouse dentate gyrus
Global remapping in granule cells and mossy cells of the mouse dentate gyrus Open
All data and analysis code is available on GitHub (GitHub: https://github.com/skim1011/KimGoodSmith_DG_remap ).
View article: Global remapping in granule cells and mossy cells of the mouse dentate gyrus
Global remapping in granule cells and mossy cells of the mouse dentate gyrus Open
SUMMARY Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, the dentate gyrus (DG) has two excitatory po…
View article: Closed-loop control and recalibration of place cells by optic flow
Closed-loop control and recalibration of place cells by optic flow Open
Understanding the interplay between sensory input, endogenous neural dynamics, and behavioral output is key toward understanding the principles of neural computation. Hippocampal place cells are an ideal system to investigate this closed-l…
View article: Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1
Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1 Open
The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatiotemporal framework encoding the location and temporal context of that experience. Previous work implies a distincti…
View article: Loss of functional heterogeneity along the CA3 transverse axis in aging
Loss of functional heterogeneity along the CA3 transverse axis in aging Open
View article: Flexible encoding of objects and space in single cells of the dentate gyrus
Flexible encoding of objects and space in single cells of the dentate gyrus Open
View article: Prospective Learning: Principled Extrapolation to the Future
Prospective Learning: Principled Extrapolation to the Future Open
Learning is a process which can update decision rules, based on past experience, such that future performance improves. Traditionally, machine learning is often evaluated under the assumption that the future will be identical to the past i…
View article: Wide-angle, monocular head tracking using passive markers
Wide-angle, monocular head tracking using passive markers Open
View article: Loss of functional heterogeneity along the CA3 transverse axis in aging
Loss of functional heterogeneity along the CA3 transverse axis in aging Open
Age-related deficits in pattern separation have been postulated to bias the output of hippocampal memory processing toward pattern completion, which can cause deficits in accurate memory retrieval. While the CA3 region of the hippocampus i…
View article: Wide-Angle, Monocular Head Tracking using Passive Markers
Wide-Angle, Monocular Head Tracking using Passive Markers Open
Camera images can encode large amounts of visual information of an animal and its environment, enabling high fidelity 3D reconstruction of the animal and its environment using computer vision methods. Most systems, both markerless (e.g. de…
View article: The Dome: A virtual reality apparatus for freely locomoting rodents
The Dome: A virtual reality apparatus for freely locomoting rodents Open
View article: Flexible encoding of objects and space in single cells of the dentate gyrus
Flexible encoding of objects and space in single cells of the dentate gyrus Open
Summary The hippocampus is involved in the formation of memories that require associations among stimuli to construct representations of space and the items and events within that space. Neurons in the dentate gyrus (DG), an initial input …
View article: Heterogeneity of Age-Related Neural Hyperactivity along the CA3 Transverse Axis
Heterogeneity of Age-Related Neural Hyperactivity along the CA3 Transverse Axis Open
Age-related memory deficits are correlated with neural hyperactivity in the CA3 region of the hippocampus. Abnormal CA3 hyperactivity in aged rats has been proposed to contribute to an imbalance between pattern separation and pattern compl…