James Kolasinski
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View article: Association between tDCS induced GABA change and estimated electric field in the cortex
Association between tDCS induced GABA change and estimated electric field in the cortex Open
Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro- behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by inter-subject variability in responses, …
View article: tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel
tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel Open
Background and Objective Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inte…
A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming Open
Myelination has been increasingly implicated in the function and dysfunction of the adult human brain. Although it is known that axon myelination shapes axon physiology in animal models, it is unclear whether a similar principle applies in…
Multi-centre, multi-vendor 7 Tesla fMRI reproducibility of hand digit representation in the human somatosensory cortex Open
Whilst considerable progress has been made in using ultra-high field fMRI to study brain function at fine spatial resolution, methods are generally optimized at a single site and do not translate to studies where multiple sites are require…
View article: Chronic musculoskeletal impairment is associated with alterations in brain regions responsible for the production and perception of movement
Chronic musculoskeletal impairment is associated with alterations in brain regions responsible for the production and perception of movement Open
Key points Massive irreparable rotator cuff tear was used as a model to study the impact of chronic pain and motor impairment on the motor systems of the human brain using magnetic resonance imaging. Patients show markers of lower grey/whi…
Directional biases in whole hand motion perception revealed by mid-air tactile stimulation Open
Human machine interfaces are increasingly designed to reduce our reliance on the dominantly used senses of vision and audition. Many emerging technologies are attempting to convey complex spatiotemporal information via tactile percepts sho…
Spatially and Temporally Distinct Encoding of Muscle and Kinematic Information in Rostral and Caudal Primary Motor Cortex Open
The organizing principle of human motor cortex does not follow an anatomical body map, but rather a distributed representational structure in which motor primitives are combined to produce motor outputs. Electrophysiological recordings in …
A Role for the Action Observation Network in Apraxia After Stroke Open
Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right…
Relating diffusion tensor imaging measurements to microstructural quantities in the cerebral cortex in multiple sclerosis Open
To investigate whether the observed anisotropic diffusion in cerebral cortex may reflect its columnar cytoarchitecture and myeloarchitecture, as a potential biomarker for disease‐related changes, we compared postmortem diffusion magnetic r…
Spatially and temporally distinct encoding of muscle and kinematic information in rostral and caudal primary motor cortex Open
Hand movements are controlled by neuronal networks in primary motor cortex (M1). The organising principle in M1 does not follow an anatomical body map, but rather a distributed representational structure in which motor primitives are combi…
The dynamics of cortical GABA in human motor learning Open
The ability to learn novel motor skills is both a central part of our daily lives and can provide a model for rehabilitation after a stroke. However, there are still fundamental gaps in our understanding of the physiological mechanisms tha…
Perceptually relevant remapping of human somatotopy in 24 hours Open
Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human…
Author response: Perceptually relevant remapping of human somatotopy in 24 hours Open
Article Figures and data Abstract eLife digest Introduction Materials and methods References Decision letter Author response Article and author information Metrics Abstract Experience-dependent reorganisation of functional maps in the cere…
Author response: Revealing the neural fingerprints of a missing hand Open
Article Figures and data Abstract eLife digest Introduction Materials and methods References Decision letter Author response Article and author information Metrics Abstract The hand area of the primary somatosensory cortex contains detaile…
Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates Open
Extrastriate visual area V5/MT in primates is defined both structurally by myeloarchitecture and functionally by distinct responses to visual motion. Myelination is directly identifiable from postmortem histology but also indirectly by ima…
Investigating the Stability of Fine-Grain Digit Somatotopy in Individual Human Participants Open
Studies of human primary somatosensory cortex (S1) have placed a strong emphasis on the cortical representation of the hand and the propensity for plasticity therein. Despite many reports of group differences and experience-dependent chang…