J. Bradley Layton
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View article: Temporal Changes in SGLT2 Inhibitor and GLP-1 Receptor Agonist Use in Patients with Chronic Kidney Disease and Type 2 Diabetes, 2012–2023: A US Cohort Study
Temporal Changes in SGLT2 Inhibitor and GLP-1 Receptor Agonist Use in Patients with Chronic Kidney Disease and Type 2 Diabetes, 2012–2023: A US Cohort Study Open
These findings inform and contextualize future studies assessing cardiorenal outcomes for these and additional treatments, including finerenone, for individuals with CKD and type 2 diabetes.
View article: Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States
Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States Open
Introduction Neurologic or immune-mediated conditions have been evaluated as potential adverse events (AEs) in coronavirus disease 2019 (COVID-19) vaccine safety surveillance. To contextualize United States (US) surveillance findings, it i…
View article: Pneumococcal Vaccine Use and Immunogenicity in Patients with Glomerular Disease: A Scoping Review and Analysis of Healthcare Claims Data
Pneumococcal Vaccine Use and Immunogenicity in Patients with Glomerular Disease: A Scoping Review and Analysis of Healthcare Claims Data Open
Introduction: Streptococcus pneumoniae infections are a preventable cause of morbidity and mortality in individuals with glomerular disease. There is limited immunogenicity data to inform the effectiveness of vaccination in this high-risk …
View article: Effectiveness over time of a primary series of the original monovalent COVID-19 vaccines in adults in the United States
Effectiveness over time of a primary series of the original monovalent COVID-19 vaccines in adults in the United States Open
With data from 2 US claims databases (Optum, CVS Health) supplemented with Immunization Information System COVID-19 vaccine records, we evaluated overall and time-specific vaccine effectiveness (VE) of an initial primary series for 3 monov…
View article: Evaluation of Mortality in Users of Pimavanserin Compared with Other Atypical Antipsychotics in Patients with Parkinson’s Disease Psychosis: An Update
Evaluation of Mortality in Users of Pimavanserin Compared with Other Atypical Antipsychotics in Patients with Parkinson’s Disease Psychosis: An Update Open
In the overall PDP cohort, mortality risk was lower among pimavanserin initiators than comparator antipsychotic initiators.
View article: Remote Phenotyping Strategies for Sunflower Flowering Assessments Using Deep Learning Approaches
Remote Phenotyping Strategies for Sunflower Flowering Assessments Using Deep Learning Approaches Open
The flowering date of sunflowers is a crucial trait that significantly influences crop management practices and product placement. Traditional ground methods for data collection are labor-intensive and subjective, requiring field scientist…
View article: Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study
Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study Open
During 2012-2021, GLP-1 RA use steadily increased across multinational cohorts of patients with T2D and CKD, and persistence with treatment was high. GLP-1 use was independent of CKD severity.
View article: Inhalation anesthesia and total intravenous anesthesia (TIVA) regimens in patients with obesity: an updated systematic review and meta-analysis of randomized controlled trials
Inhalation anesthesia and total intravenous anesthesia (TIVA) regimens in patients with obesity: an updated systematic review and meta-analysis of randomized controlled trials Open
Background Obesity is a global epidemic, projected to affect 4 billion people by 2035. Anesthesia regimens, including volatile anesthetics and total intravenous anesthesia (TIVA), impact postoperative outcomes, particularly in obese patien…
View article: A Comparative Real‐World Study Evaluating the Safety of Immune Globulin Infusion (Human) 10% Solution and Other Intravenous Immunoglobulin Therapies for the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
A Comparative Real‐World Study Evaluating the Safety of Immune Globulin Infusion (Human) 10% Solution and Other Intravenous Immunoglobulin Therapies for the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open
Purpose Immune globulin infusion (human) 10% solution (GAMMAGARD LIQUID; GGL), an intravenous immunoglobulin (IVIG), has recently received U.S. approval for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We evaluated thr…
View article: Change in Urine Albumin-Creatinine Ratio and Occurrence of Hyperkalemia in Patients Initiating Finerenone in the USA: A Cohort Study from the FOUNTAIN Platform
Change in Urine Albumin-Creatinine Ratio and Occurrence of Hyperkalemia in Patients Initiating Finerenone in the USA: A Cohort Study from the FOUNTAIN Platform Open
Introduction: In 2021, finerenone – a novel, selective nonsteroidal mineralocorticoid receptor antagonist – was approved in the USA to treat adults with chronic kidney disease (CKD) and type 2 diabetes (T2D). This study aimed to describe c…
View article: Adapting the European Concerted Action on Congenital Anomalies and Twins (<scp>EUROCAT</scp>) Guide 1.5 for Use in Post‐Authorisation Safety Studies Using US Data
Adapting the European Concerted Action on Congenital Anomalies and Twins (<span>EUROCAT</span>) Guide 1.5 for Use in Post‐Authorisation Safety Studies Using US Data Open
Purpose Many post‐authorization safety studies focus on congenital malformations and rely on diagnosis codes found in US data sources. However, no authoritative standards exist for identifying and classifying malformations in these data. T…
View article: Evaluating the Risk of Cardiovascular Adverse Events and Appendicitis After COVID-19 Diagnosis in Adults in the United States: Implications of the Start of Follow-Up
Evaluating the Risk of Cardiovascular Adverse Events and Appendicitis After COVID-19 Diagnosis in Adults in the United States: Implications of the Start of Follow-Up Open
Purpose This study evaluated the association between coronavirus disease 2019 (COVID-19) diagnosis and adverse events (AEs), including cardiovascular AEs and appendicitis, in US adults before the introduction of COVID-19 vaccines. Real-wor…
View article: Effectiveness Over Time of a Primary Series of the Original Monovalent COVID-19 Vaccines in Adults in the United States
Effectiveness Over Time of a Primary Series of the Original Monovalent COVID-19 Vaccines in Adults in the United States Open
With data from 2 US claims databases (Optum, CVS Health) supplemented with Immunization Information System COVID 19 vaccine records, we evaluated overall and time-specific vaccine effectiveness (VE) of an initial primary series for 3 monov…
View article: Risk of Neurologic or Immune-Mediated Adverse Events After COVID-19 Diagnosis in the United States
Risk of Neurologic or Immune-Mediated Adverse Events After COVID-19 Diagnosis in the United States Open
Background Many neurologic or immune-mediated conditions have been evaluated as potential adverse events (AEs) in coronavirus disease 2019 (COVID-19) vaccine safety surveillance. To contextualize United States (US) surveillance findings, i…
View article: #2022 Clinical outcomes in US patients initiating finerenone – a report from the FOUNTAIN platform
#2022 Clinical outcomes in US patients initiating finerenone – a report from the FOUNTAIN platform Open
Background and Aims Evidence from clinical trials demonstrates that finerenone reduces the risk of cardiovascular and renal complications among patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). What is lacking is the ev…
View article: Effectiveness of BNT162b2 COVID-19 primary series vaccination in children aged 5–17 years in the United States: a cohort study
Effectiveness of BNT162b2 COVID-19 primary series vaccination in children aged 5–17 years in the United States: a cohort study Open
Background COVID-19 vaccines are authorized for use in children in the United States; real-world assessment of vaccine effectiveness in children is needed. This study’s objective was to estimate the effectiveness of receiving a complete pr…
View article: Accuracy of Self-Reported Heart Failure. The Atherosclerosis Risk in Communities (ARIC) Study
Accuracy of Self-Reported Heart Failure. The Atherosclerosis Risk in Communities (ARIC) Study Open
Objective The aim of this work was to estimate agreement of self-reported heart failure (HF) with physician-diagnosed HF and compare the prevalence of HF according to method of ascertainment. Methods and Results ARIC cohort members (60–83 …
View article: Misinterpretation of the comparative safety of testosterone dosageforms-reply
Misinterpretation of the comparative safety of testosterone dosageforms-reply Open
We appreciate the point of view expressed by Dr. Schooling and agree that given widespread use of testosterone products, a thorough investigation of its cardiovascular safety is crucial. Understanding whether testosterone treatment (in any…
View article: The comparative risk of acute kidney injury of vancomycin relative to other common antibiotics
The comparative risk of acute kidney injury of vancomycin relative to other common antibiotics Open
The glycopeptide antibiotic vancomycin is a mainstay in the treatment of Gram-positive infection. While its association with acute kidney injury (AKI) has waxed and waned, recent data suggest nephrotoxicity, even as mono-therapy. Our study…
View article: Injection testosterone and adverse cardiovascular events: A case-crossover analysis
Injection testosterone and adverse cardiovascular events: A case-crossover analysis Open
Context: Exogenous testosterone administration may affect blood clotting, polycythaemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies hav…
View article: Association Between an Acute, Drug-Induced Decrease in High-Density Lipoprotein Cholesterol Levels and Risk of Cardiovascular Events
Association Between an Acute, Drug-Induced Decrease in High-Density Lipoprotein Cholesterol Levels and Risk of Cardiovascular Events Open
Background and Objective: The literature describing the long-term effect of an acute, drug-induced decrease in high-density lipoprotein cholesterol (HDL-C) and cardiovascular (CV) risk is limited. We aimed to further explore this potential…
View article: Influenza Vaccine Administration and Effectiveness Among Children and Adults With Glomerular Disease
Influenza Vaccine Administration and Effectiveness Among Children and Adults With Glomerular Disease Open
Rates of influenza vaccination are suboptimal among patients with GD. Protection from influenza after vaccination may be poor, leading to excess infection-related morbidity in this vulnerable population.