James Lewsey
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View article: Frailty in COPD: an analysis of prevalence and clinical impact using UK Biobank
Frailty in COPD: an analysis of prevalence and clinical impact using UK Biobank Open
Background Frailty, a state of reduced physiological reserve, is common in people with chronic obstructive pulmonary disease (COPD). Frailty can occur at any age; however, the implications in younger people (eg, aged 65 years.
View article: A comparison of routine and case-managed pathways for recovery from musculoskeletal disorders in people in employment
A comparison of routine and case-managed pathways for recovery from musculoskeletal disorders in people in employment Open
People with musculoskeletal disorders who have poor baseline mental health status derive greatest benefit from active case-management. Case-management therefore contributes to reducing health inequalities and can help to minimise long-term…
View article: Risk assessments and structured care interventions for prevention of foot ulceration in diabetes: development and validation of a prognostic model
Risk assessments and structured care interventions for prevention of foot ulceration in diabetes: development and validation of a prognostic model Open
Background Diabetes-related foot ulcers give rise to considerable morbidity, generate a high monetary cost for health and social care services and precede the majority of diabetes-related lower extremity amputations. There are many clinica…
View article: Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions
Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions Open
Aims To investigate the population attributable fraction due to elevated lipoprotein (a) (Lp(a)) and the utility of measuring Lp(a) in cardiovascular disease (CVD) risk prediction. Methods and results In 413 734 participants from UK Bioban…
View article: Real-World Estimates of Adrenal Insufficiency–Related Adverse Events in Children With Congenital Adrenal Hyperplasia
Real-World Estimates of Adrenal Insufficiency–Related Adverse Events in Children With Congenital Adrenal Hyperplasia Open
Background Although congenital adrenal hyperplasia (CAH) is known to be associated with adrenal crises (AC), its association with patient- or clinician-reported sick day episodes (SDE) is less clear. Methods Data on children with classic 2…
View article: Evaluating the impact of Minimum Unit Pricing (MUP) on sales-based alcohol consumption in Scotland: controlled interrupted time series analyses.
Evaluating the impact of Minimum Unit Pricing (MUP) on sales-based alcohol consumption in Scotland: controlled interrupted time series analyses. Open
This study looks at the impact of minimum unit pricing (MUP) for alcohol that came into effect in Scotland in 2018. The report assesses the impact of MUP on population level alcohol consumption at one year post-MUP.
View article: Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions
Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions Open
Background Lipoprotein (a) (Lp(a)) is a CVD risk factor amenable to intervention and might help guide risk prediction. Objectives To investigate the population attributable fraction due to elevated Lp(a) and its utility in risk prediction.…
View article: MON-170 Real World Estimates of Adrenal Insufficiency Related Adverse Events in Children with Congenital Adrenal Hyperplasia: On Behalf of the I-CAH Consortium
MON-170 Real World Estimates of Adrenal Insufficiency Related Adverse Events in Children with Congenital Adrenal Hyperplasia: On Behalf of the I-CAH Consortium Open
Background Although congenital adrenal hyperplasia (CAH) is a rare condition, it is the commonest cause of early-onset primary adrenal insufficiency and places the patient at a life-long risk of sick day episodes (SDE) and adrenal crises (…
View article: Glycated Hemoglobin, Prediabetes, and the Links to Cardiovascular Disease: Data From UK Biobank
Glycated Hemoglobin, Prediabetes, and the Links to Cardiovascular Disease: Data From UK Biobank Open
OBJECTIVE HbA1c levels are increasingly measured in screening for diabetes; we investigated whether HbA1c may simultaneously improve cardiovascular disease (CVD) risk assessment, using QRISK3, American College of Cardiology/American Heart …
View article: How did a lower drink‐drive limit affect bar trade and drinking practices? A qualitative study of how alcohol retailers experienced a change in policy
How did a lower drink‐drive limit affect bar trade and drinking practices? A qualitative study of how alcohol retailers experienced a change in policy Open
Introduction and Aims Reducing the legal drink‐drive limit from 0.08% to 0.05% blood alcohol concentration (BAC) can reduce road traffic accidents and deaths if properly enforced. Reduced limits may be opposed by alcohol retail and manufac…
View article: Do age, period or cohort effects explain circulatory disease mortality trends, Scotland 1974–2015?
Do age, period or cohort effects explain circulatory disease mortality trends, Scotland 1974–2015? Open
Objective We aimed to explore whether age, period or cohort effects explain the trends and inequalities in ischaemic heart disease (IHD) and cerebrovascular disease (CeVD) mortality in Scotland. Methods We analysed IHD and CeVD deaths for …
View article: What causes the burden of stroke in Scotland? A comparative risk assessment approach linking the Scottish Health Survey to administrative health data
What causes the burden of stroke in Scotland? A comparative risk assessment approach linking the Scottish Health Survey to administrative health data Open
This study provides evidence for prioritising interventions that tackle socioeconomic inequalities as a means of achieving the greatest reduction in avoidable strokes in Scotland. Future work to disentangle the proportion of the effect of …
View article: Evidence synthesis for constructing directed acyclic graphs (ESC-DAGs): a novel and systematic method for building directed acyclic graphs
Evidence synthesis for constructing directed acyclic graphs (ESC-DAGs): a novel and systematic method for building directed acyclic graphs Open
Background Directed acyclic graphs (DAGs) are popular tools for identifying appropriate adjustment strategies for epidemiological analysis. However, a lack of direction on how to build them is problematic. As a solution, we propose using a…
View article: Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease
Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease Open
Background: Total cholesterol and high-density lipoprotein cholesterol (HDL-C) measurements are central to cardiovascular disease (CVD) risk assessment, but there is continuing debate around the utility of other lipids for risk prediction.…
View article: Association of Total and Differential Leukocyte Counts With Cardiovascular Disease and Mortality in the UK Biobank
Association of Total and Differential Leukocyte Counts With Cardiovascular Disease and Mortality in the UK Biobank Open
Objective— Elevated white blood cell count is associated with a higher risk of cardiovascular disease (CVD). We aimed to investigate whether specific leukocyte subpopulations, which may more closely indicate a specific inflammatory pathway…
View article: Synthetic control methodology as a tool for evaluating population-level health interventions
Synthetic control methodology as a tool for evaluating population-level health interventions Open
Background Many public health interventions cannot be evaluated using randomised controlled trials so they rely on the assessment of observational data. Techniques for evaluating public health interventions using observational data include…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
No abstract is available for this article.
View article: Additional file 2: of Drug-related deaths in Scotland 1979â 2013: evidence of a vulnerable cohort of young men living in deprived areas
Additional file 2: of Drug-related deaths in Scotland 1979â 2013: evidence of a vulnerable cohort of young men living in deprived areas Open
Regression models and interpretation of intrinsic estimator coefficients. Table S1. Goodness-of-fit statistics for single and two factor regression models and APC model. Table S2. Goodness-of-fit statistics for single and two factor regres…
View article: Do patients who die from an alcohol-related condition ‘drift’ into areas of greater deprivation? Alcohol-related mortality and health selection theory in Scotland
Do patients who die from an alcohol-related condition ‘drift’ into areas of greater deprivation? Alcohol-related mortality and health selection theory in Scotland Open
Background Health selection has been proposed to explain the patterning of alcohol-related mortality by area deprivation. This study investigated whether persons who die from alcohol-related conditions are more likely to experience social …
View article: Drug Related Deaths in Scotland
Drug Related Deaths in Scotland Open
This describes a study that involved age-period-cohort analyses to investigate whether cohort effects from exposure to the changing political context from the 1980s could explain the recent trends in drug-related deaths in Scotland. We pre…
View article: The short‐term impact of the alcohol act on alcohol‐related deaths and hospital admissions in Scotland: a natural experiment
The short‐term impact of the alcohol act on alcohol‐related deaths and hospital admissions in Scotland: a natural experiment Open
Background and aim The introduction of the Alcohol Act in Scotland on 1 October 2011, which included a ban on multi‐buy promotions, was probably associated with a fall in off‐trade alcohol sales in the year after its implementation. The ai…
View article: Drug Related Deaths in Scotland
Drug Related Deaths in Scotland Open
This describes a study that involved age-period-cohort analyses to investigate whether cohort effects from exposure to the changing political context from the 1980s could explain the recent trends in drug-related deaths in Scotland. We pre…