James Lister
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View article: Supplementary Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Supplementary Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
Supplementary File comprising of Supplementary Material and Methods, Supplementary References and Supplementary Figures S1-S7. Figure S1: IHC of melanoma and proliferation markers; Figure S2: Images of fish used for bulk RNA-seq, Figure S3…
View article: Supplementary Tables S1-S8 from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Supplementary Tables S1-S8 from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
Supplementary file comprising Supplementary Tables S1-S8. Table S1: list of antibodies used in this study; Table S2: gene set from literature used for pathway analysis; Table S3: list of significantly enriched pathways from GSEA analysis b…
View article: Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
The melanocyte-inducing transcription factor (MITF)–low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking. Here, we used zeb…
View article: Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
The melanocyte-inducing transcription factor (MITF)–low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking. Here, we used zeb…
View article: Supplementary Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Supplementary Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
Supplementary File comprising of Supplementary Material and Methods, Supplementary References and Supplementary Figures S1-S7. Figure S1: IHC of melanoma and proliferation markers; Figure S2: Images of fish used for bulk RNA-seq, Figure S3…
View article: Supplementary Tables S1-S8 from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Supplementary Tables S1-S8 from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
Supplementary file comprising Supplementary Tables S1-S8. Table S1: list of antibodies used in this study; Table S2: gene set from literature used for pathway analysis; Table S3: list of significantly enriched pathways from GSEA analysis b…
View article: Lysophosphatidic acid signaling via <scp>LPA<sub>6</sub></scp>: A negative modulator of developmental oligodendrocyte maturation
Lysophosphatidic acid signaling via <span>LPA<sub>6</sub></span>: A negative modulator of developmental oligodendrocyte maturation Open
The developmental process of central nervous system (CNS) myelin sheath formation is characterized by well‐coordinated cellular activities ultimately ensuring rapid and synchronized neural communication. During this process, myelinating CN…
View article: The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor
The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor Open
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neura…
View article: Dataset for Petratou, Spencer, Kelsh and Lister 'The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor'
Dataset for Petratou, Spencer, Kelsh and Lister 'The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor' Open
The data consist of (1) iridophore counts in WT or tfec mutant embryos at 3 dpf (Fig. 3F); (2) iridophore counts from tfec mutants injected with tfec cDNA construct or uninjected controls (Fig. 3K); (3) iridophore counts from WT embryos in…
View article: Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure
Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure Open
A critical step in eye development is closure of the choroid fissure (CF), a transient structure in the ventral optic cup through which vasculature enters the eye and ganglion cell axons exit. While many factors have been identified that f…
View article: Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure
Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure Open
A critical step in eye development is closure of the choroid fissure (CF), a transient structure in the ventral optic cup through which vasculature enters the eye and ganglion cell axons exit. While many factors have been identified that f…
View article: The<i>MITF</i>paralog<i>tfec</i>is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor
The<i>MITF</i>paralog<i>tfec</i>is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor Open
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neura…
View article: Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease Open
The melanocyte-inducing transcription factor (MITF)–low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking. Here, we used zeb…
View article: A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest
A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest Open
Multipotent neural crest (NC) progenitors generate an astonishing array of derivatives, including neuronal, skeletal components and pigment cells (chromatophores), but the molecular mechanisms allowing balanced selection of each fate remai…
View article: PO-214 Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
PO-214 Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models Open
Introduction Melanoma is the most lethal type of skin cancer and its incidence continues to rise rapidly. While BRAFV600E inhibitors have led to significant improvements in outcomes for some patients, there are no targeted therapies avail…
View article: A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest
A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest Open
Multipotent neural crest (NC) progenitors generate an astonishing array of derivatives, including neuronal, skeletal components and pigment cells (chromatophores), but the molecular mechanisms allowing balanced selection of each fate remai…
View article: The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation
The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation Open
The formation of the axon insulating and supporting myelin sheath by differentiating oligodendrocytes (OLGs) in the CNS is considered an essential step during vertebrate development. In addition, loss and/or dysfunction of the myelin sheat…