Nicholas J. Long
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View article: Metallocenium salts as tunable dopants for enhanced efficiency of perovskite solar cells
Metallocenium salts as tunable dopants for enhanced efficiency of perovskite solar cells Open
The generation of free carriers through doping is essential for transforming the electronic properties of organic semiconductors (OSCs). We show that metallocenium salts facilitate OSC doping, enabling high-performance perovskite solar cel…
View article: Tetrazine- <i>trans</i> -cyclooctene ligated lanthanide conjugates for biomedical imaging
Tetrazine- <i>trans</i> -cyclooctene ligated lanthanide conjugates for biomedical imaging Open
Tetrazine-functionalised lanthanide chelates and their catalyst-free ‘click’ reactions with a trans -cyclooctene-rhodamine fluorophore are reported. These probes were delivered across the blood–brain barrier using focused ultrasound and mi…
View article: A translatable evaluation tool to study the biodistribution of clinically-available doxorubicin liposomes: PET imaging of [<sup>89</sup>Zr]Zr-Doxil and [<sup>89</sup>Zr]Zr-Talidox
A translatable evaluation tool to study the biodistribution of clinically-available doxorubicin liposomes: PET imaging of [<sup>89</sup>Zr]Zr-Doxil and [<sup>89</sup>Zr]Zr-Talidox Open
INTRODUCTION Doxil/Caelyx is a PEGylated liposomal formulation of the chemotherapeutic doxorubicin used in the clinic for Kaposi’s sarcoma, advanced ovarian cancer, progressive multiple myeloma and metastatic breast cancer. Talidox ® , a s…
View article: Ferrocene Derivatives Enable Ultrasensitive Perovskite Photodetectors with Enhanced Reverse Bias Stability
Ferrocene Derivatives Enable Ultrasensitive Perovskite Photodetectors with Enhanced Reverse Bias Stability Open
Despite the great potential of lead‐halide perovskite photodetectors for broadband photodetection, ion migration in perovskites and parasitic charge injection from adjacent layers remain major challenges, ultimately leading to device failu…
View article: An Efficient Solid‐Phase Synthetic Approach to Prepare TACN‐Functionalized Peptides
An Efficient Solid‐Phase Synthetic Approach to Prepare TACN‐Functionalized Peptides Open
1,4,7‐triazacyclononane (TACN) derivatives play important roles in various metal‐based biomedical applications. However, the unmanageable functionalization of TACN remains a long‐standing challenge to yield useful partially substituted bui…
View article: Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High‐Performance Perovskite Solar Cells
Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High‐Performance Perovskite Solar Cells Open
Achieving rational control over chemical and energetic properties at the perovskite/electron transport layer (ETL) interface is crucial for realizing highly efficient and stable next‐generation inverted perovskite solar cells (PSCs). To ad…
View article: Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High‐Performance Perovskite Solar Cells
Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High‐Performance Perovskite Solar Cells Open
Achieving rational control over chemical and energetic properties at the perovskite/electron transport layer (ETL) interface is crucial for realizing highly efficient and stable next‐generation inverted perovskite solar cells (PSCs). To ad…
View article: NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1
NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1 Open
Heme oxygenase-1 (HO-1) catalyzes heme degradation on the consumption of NADPH and molecular oxygen. As an inducible enzyme, HO-1 is highly induced in various disease states, including cancer. Currently, two fluorescent probes for HO-1 hav…
View article: A pinch of silver salt to enable <i>rac</i>-lactide ring-opening polymerisation at room temperature using Ti-salen complexes
A pinch of silver salt to enable <i>rac</i>-lactide ring-opening polymerisation at room temperature using Ti-salen complexes Open
Exploiting non-covalent interactions (NCIs) has become a powerful tool in catalyst design, including those for polymerisation reactions.
View article: Light-driven molecular switching achieves 6-order magnitude conductance change in OPE dimers
Light-driven molecular switching achieves 6-order magnitude conductance change in OPE dimers Open
(a) OPE3 meta and para -junctions. (b) Transmission T ( E ) vs. energy.
View article: The synthesis and optical properties of Cu–In–S/ZnS nanocrystals in buffer solution for near-infrared fluorescence imaging
The synthesis and optical properties of Cu–In–S/ZnS nanocrystals in buffer solution for near-infrared fluorescence imaging Open
In this report, we describe the synthesis of infrared emitting CuInS 2 /ZnS quantum dots in buffer solution, the role of the buffer and the use of the particles in imaging.
View article: Lanthanide–tetrazine probes for bio-imaging and click chemistry
Lanthanide–tetrazine probes for bio-imaging and click chemistry Open
Lanthanide–tetrazine complexes were synthesised and evaluated via optical spectroscopy and relaxivity. A bio-orthogonal click reaction with a cyclic-RGD-peptide was successful and the resulting Gd complex demonstrated enhanced relaxivity.
View article: Bioorthogonal activation and mitochondrial targeting of a near-infrared-emitting iridium(<scp>iii</scp>) nitrone complex <i>via</i> cyclooctynylated phosphonium cations for enhanced cellular imaging and photodynamic therapy
Bioorthogonal activation and mitochondrial targeting of a near-infrared-emitting iridium(<span>iii</span>) nitrone complex <i>via</i> cyclooctynylated phosphonium cations for enhanced cellular imaging and photodynamic therapy Open
In this work, we present the bioorthogonal activation and mitochondria targeting of a near-infrared-emitting iridium( iii ) nitrone complex via cyclooctynylated phosphonium cations for enhanced cellular imaging and photodynamic therapy.
View article: Mass spectrometric imaging and quantitative analysis of the <i>in vivo</i> biodistribution of trastuzumab using a rhodium(<scp>iii</scp>) sarcophagine complex
Mass spectrometric imaging and quantitative analysis of the <i>in vivo</i> biodistribution of trastuzumab using a rhodium(<span>iii</span>) sarcophagine complex Open
A new immunoconjugate, Rh-sar-PD-trastuzumab, enables in vivo mapping of antibody biodistribution, and tissue imaging of HER2 expression, using ICP-MS methods.
View article: Site-specific π-clamp-mediated radiosynthesis of <sup>68</sup>Ga and <sup>18</sup>F PET radiopharmaceuticals
Site-specific π-clamp-mediated radiosynthesis of <sup>68</sup>Ga and <sup>18</sup>F PET radiopharmaceuticals Open
The π-clamp-mediated conjugation method, which enables site-specific modification of cysteine residues, is a promising strategy for developing well-defined radiolabelled biomolecules for positron emission tomography (PET) imaging.
View article: Conjugated molecular wires on indium-tin oxide: investigation of the electron transfer mechanism and application in tin perovskite solar cells
Conjugated molecular wires on indium-tin oxide: investigation of the electron transfer mechanism and application in tin perovskite solar cells Open
Electron transfer through ‘molecular wires’ underpins numerous research fields, ranging from single molecule electronics to fundamental biological processes and their application in (bio)electrocatalysis. Here, we report a series of 1-3 nm…
View article: Interface Engineering of Water-Dispersible Near-Infrared-Emitting CuInZnS/ZnSe/ZnS Quantum Dots
Interface Engineering of Water-Dispersible Near-Infrared-Emitting CuInZnS/ZnSe/ZnS Quantum Dots Open
We report the synthesis of near-infrared (IR)-emitting core/shell/shell quantum dots of CuInZnS/ZnSe/ZnS and their phase transfer to water. The intermediate ZnSe shell was added to inhibit the migration of ions from the standard ZnS shell …
View article: Highly Efficient and Scalable p-i-n Perovskite Solar Cells Enabled by Poly-metallocene Interfaces
Highly Efficient and Scalable p-i-n Perovskite Solar Cells Enabled by Poly-metallocene Interfaces Open
Inverted p-i-n perovskite solar cells (PSCs) are easy to process but need improved interface characteristics with reduced energy loss to prevent efficiency drops when increasing the active photovoltaic area. Here, we report a series of pol…
View article: Mitochondria-targeting biocompatible fluorescent BODIPY probes
Mitochondria-targeting biocompatible fluorescent BODIPY probes Open
Biocompatible fluorescent BODIPY probes with excellent quantum yields, demonstrating a high mitochondrial membrane potential (MMP)-sensitive localisation in the mitochondria. PEGylation improved biocompatibility and lowers cytotoxicity.
View article: Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy
Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy Open
Mitochondria-targeting BODIPY photosensitisers with excellent singlet oxygen generation efficiencies showed potent photocytotoxicity towards cancer cells through inducing reactive oxygen species overproduction and selective mitochondrial d…
View article: Aminocoumarin-based heme oxygenase activity fluorescence probe reveals novel aspects of HO-1 regulation
Aminocoumarin-based heme oxygenase activity fluorescence probe reveals novel aspects of HO-1 regulation Open
Heme oxygenase-1 (HO-1) is crucial for vascular health and heme homeostasis. Whilst protective, HO-1 is increased in numerous cardiovascular diseases, including atherosclerosis. We previously reported a prototype fluorescent probe for HO-1…
View article: Site-Specific <sup>68</sup>Ga Radiolabeling of Trastuzumab Fab via Methionine for ImmunoPET Imaging
Site-Specific <sup>68</sup>Ga Radiolabeling of Trastuzumab Fab via Methionine for ImmunoPET Imaging Open
Bioconjugates of antibodies and their derivatives radiolabeled with β+-emitting radionuclides can be utilized for diagnostic PET imaging. Site-specific attachment of radioactive cargo to antibody delivery vectors provides homogeneous, well…
View article: Evaluation of [18F]AlF-EMP-105 for Molecular Imaging of C-Met
Evaluation of [18F]AlF-EMP-105 for Molecular Imaging of C-Met Open
C-Met is a receptor tyrosine kinase that is overexpressed in a range of different cancer types, and has been identified as a potential biomarker for cancer imaging and therapy. Previously, a 68Ga-labelled peptide, [68Ga]Ga-EMP-100, has sho…
View article: raw data of "Homogeneous Surface Manipulation Enables Efficient and Scalable Inverted Perovskite Solar Cells"
raw data of "Homogeneous Surface Manipulation Enables Efficient and Scalable Inverted Perovskite Solar Cells" Open
Raw data of first-principles calculations for "Homogeneous Surface Manipulation Enables Efficient and Scalable Inverted Perovskite Solar Cells" from Gaussian (G16,version C01) calculations to reproduce electrostatic potential (ESP) results…
View article: Quantum Interference and Contact Effects in the Thermoelectric Performance of Anthracene-Based Molecules
Quantum Interference and Contact Effects in the Thermoelectric Performance of Anthracene-Based Molecules Open
We report on the single-molecule electronic and thermoelectric properties of strategically chosen anthracene-based molecules with anchor groups capable of binding to noble metal substrates, such as gold and platinum. Specifically, we study…