James M. Healy
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View article: Endoluminal vacuum-assisted closure for penetrating rectal injury in a pediatric patient
Endoluminal vacuum-assisted closure for penetrating rectal injury in a pediatric patient Open
View article: Tissue plasminogen activator for a rare case of neonatal empyema
Tissue plasminogen activator for a rare case of neonatal empyema Open
View article: Whole-Exome Sequencing of Syndromic Adrenocortical Carcinoma Reveals Distinct Mutational Profile From Sporadic ACC
Whole-Exome Sequencing of Syndromic Adrenocortical Carcinoma Reveals Distinct Mutational Profile From Sporadic ACC Open
Next-generation sequencing has provided genetic profiles of a large number of sporadic adrenocortical carcinomas (ACCs), but the applicability of these results to ACC cases associated with tumor predisposition syndromes is unclear. Althoug…
View article: Best Buy in Public Health or Luxury Expense?
Best Buy in Public Health or Luxury Expense? Open
Objective: To determine the cost-effectiveness of building and maintaining a dedicated pediatric operating room (OR) in Uganda from the societal perspective. Background: Despite the heavy burden of pediatric surgical disease in low-income …
View article: Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing
Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing Open
Lowering the default number of opioid pills prescribed in an EMR system is a simple, effective, cheap, and potentially scalable intervention to change prescriber behavior and decrease the amount of opioid medication prescribed after proced…
View article: A Cost-Effectiveness Analysis of a Pediatric Operating Room in Uganda
A Cost-Effectiveness Analysis of a Pediatric Operating Room in Uganda Open
View article: Comparison of Internal Medicine and General Surgery Residents' Assessments of Risk of Postsurgical Complications in Surgically Complex Patients
Comparison of Internal Medicine and General Surgery Residents' Assessments of Risk of Postsurgical Complications in Surgically Complex Patients Open
IMPORTANCE: Anticipating postsurgical complications is a vital physician skill, particularly when counseling surgically complex patients on their risks of intervention. Although internists and surgeons both counsel patients on surgical ris…
View article: A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis
A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis Open
DKK3 suppression observed in ACCs and the effects of manipulation of DKK3 expression in ACC cell lines suggest a FOXO1-mediated differentiation-promoting role for DKK3 in the adrenal cortex, silencing of which may allow adrenocortical dedi…
View article: DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma
DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma Open
View article: Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype
Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype Open
Summary Aldosterone‐producing adenomas ( APA s) and bilateral adrenal hyperplasia are important causes of secondary hypertension. Somatic mutations in KCNJ5 , CACNA1D , ATP1A1 , ATP2B3 and CTNNB1 have been described in APA s. Objective To …
View article: Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing
Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing Open
Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often unresponsive to available therapeutic strategies. The tumorigenesis of ATC and its relationship to the widely prevalent well-differentiated thyroid carcinom…