James M. Mossner
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View article: From Acute Injury to Chronic Neurodegeneration: Molecular Mechanisms Linking Secondary Brain Injury to Long-Term Pathology
From Acute Injury to Chronic Neurodegeneration: Molecular Mechanisms Linking Secondary Brain Injury to Long-Term Pathology Open
Traumatic brain injury (TBI) initiates a complex cascade of pathophysiological events that have far-reaching consequences beyond the initial injury. This review examines the current state of the literature on the mechanisms underlying neur…
View article: Neurosurgical management for chronic and end‐of‐life pain in children: A systematic review
Neurosurgical management for chronic and end‐of‐life pain in children: A systematic review Open
Introduction Chronic and end‐of‐life pain in children is underreported and undermanaged. Current guidelines for pediatric chronic pain include medical and interventional modalities; however, the inclusion of neurosurgical treatments is unc…
View article: Combined intrathecal baclofen pump revision to the cervical level and lumbosacral ventral-dorsal rhizotomy for severe medically refractory hypertonia: illustrative cases
Combined intrathecal baclofen pump revision to the cervical level and lumbosacral ventral-dorsal rhizotomy for severe medically refractory hypertonia: illustrative cases Open
BACKGROUND Medically refractory hypertonia (MRH) within the pediatric population causes severe disability and is difficult to treat. Neurosurgery for mixed MRH includes intrathecal baclofen (ITB) and lumbosacral ventral-dorsal rhizotomy (V…
View article: Heterotopic Osteotomy for Intrathecal Baclofen Test Dose Administration in a Pediatric Patient With Spinal Fusion: A Technical Note
Heterotopic Osteotomy for Intrathecal Baclofen Test Dose Administration in a Pediatric Patient With Spinal Fusion: A Technical Note Open
BACKGROUND AND IMPORTANCE: Intrathecal baclofen (ITB) pumps are used for the treatment of pediatric movement disorders that are rapidly progressive or do not respond to medical management. An ITB test dose is indicated in patients who have…
View article: Feasibility of targeting the cingulate gyrus using high-intensity focused ultrasound on a cadaveric specimen: illustrative case
Feasibility of targeting the cingulate gyrus using high-intensity focused ultrasound on a cadaveric specimen: illustrative case Open
BACKGROUND Cancer is commonly associated with pain. For patients with advanced cancer and intractable pain, ablative neurosurgical procedures can significantly improve pain and transition patients out of inpatient settings. These procedure…
View article: Cervicothoracic ventral-dorsal rhizotomy for treatment of brachial hypertonia in cerebral palsy
Cervicothoracic ventral-dorsal rhizotomy for treatment of brachial hypertonia in cerebral palsy Open
View article: Safety and efficacy of continuous intrathecal baclofen via cervical catheter tip: a retrospective case series
Safety and efficacy of continuous intrathecal baclofen via cervical catheter tip: a retrospective case series Open
OBJECTIVE Intrathecal baclofen (ITB) is an effective treatment for hypertonia in children involving the implantation of a pump and catheter system. The highest concentration of ITB is at the catheter tip. The catheter tip location is most …
View article: Nonselective lumbosacral ventral-dorsal rhizotomy for the management of lower-limb hypertonia in nonambulatory children with cerebral palsy
Nonselective lumbosacral ventral-dorsal rhizotomy for the management of lower-limb hypertonia in nonambulatory children with cerebral palsy Open
OBJECTIVE Children with cerebral palsy (CP) often experience medically refractory hypertonia, for which there are surgical therapies including neuromodulation and rhizotomy. Traditional surgical treatment for medically refractory mixed hyp…
View article: Occipital nerve stimulation in pediatric patients with refractory occipital neuralgia
Occipital nerve stimulation in pediatric patients with refractory occipital neuralgia Open
View article: Cervicothoracic Ventral-Dorsal Rhizotomy for Treatment of Brachial Hypertonia in Cerebral Palsy
Cervicothoracic Ventral-Dorsal Rhizotomy for Treatment of Brachial Hypertonia in Cerebral Palsy Open
Purpose Cervicothoracic ventral-dorsal rhizotomy (VDR) is a potential treatment of medically refractory hypertonia in children who are not candidates for intrathecal baclofen, particularly in cases of severe upper limb hypertonia with limi…
View article: Cancer-associated fibroblast–secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas
Cancer-associated fibroblast–secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas Open
View article: Reversible Vagal Nerve Stimulation-Induced Vocal Cord Paralysis and Intractable Neck Pain Following a Syncopal Fall: A Case Report
Reversible Vagal Nerve Stimulation-Induced Vocal Cord Paralysis and Intractable Neck Pain Following a Syncopal Fall: A Case Report Open
View article: Safety and efficacy of intrathecal baclofen trials for the treatment of hypertonia: a retrospective cohort study
Safety and efficacy of intrathecal baclofen trials for the treatment of hypertonia: a retrospective cohort study Open
OBJECTIVE Intrathecal baclofen (ITB) is an effective treatment for refractory hypertonia in children. ITB has long been effective for the treatment of spasticity, and indications have naturally evolved to include dystonia and mixed pediatr…
View article: Cingulate Gyrus Access with Focused Ultrasound Ablation
Cingulate Gyrus Access with Focused Ultrasound Ablation Open
Cancer is associated with pain in a high number of patients. The higher the stage of cancer the more likely there is an associated pain condition. With terminally ill cancer pain patients, ablative neurosurgical procedures can significantl…
View article: Longitudinal scoliosis behavior in Chiari malformation with and without syringomyelia
Longitudinal scoliosis behavior in Chiari malformation with and without syringomyelia Open
OBJECTIVE The objective of this study was to understand the natural history of scoliosis in patients with Chiari malformation type I (CM-I) with and without syringomyelia. METHODS A retrospective review of data was conducted. Patients with…
View article: Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior
Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior Open
Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MECP2. Mutations of Mecp2 that are restricted to GABAergic cell types largely replicate the behavioral phenotypes associated with mouse models …
View article: Author response: Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior
Author response: Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior Open
View article: Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits
Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits Open
View article: Distinct contributions of three GABAergic interneuron populations to a mouse model of Rett Syndrome
Distinct contributions of three GABAergic interneuron populations to a mouse model of Rett Syndrome Open
Background Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MeCP2. MeCP2 is a transcriptional regulator active in many cell types throughout the brain. However, mutations of MeCP2 restricted t…
View article: Evaluating Surgeon Scorecards
Evaluating Surgeon Scorecards Open