James M. Njunge
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View article: Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries
Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries Open
Childhood mortality remains high in low-resource settings, where environmental enteric dysfunction (EED) is prevalent. Peripheral blood bacterial lipopolysaccharides (LPS) are potential biomarkers of intestinal microbial translocation and …
View article: Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia
Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia Open
In resource-limited settings, children often experience poor growth following illness, but the mechanisms are poorly understood. This cohort study in six countries in sub-Saharan Africa and south Asia investigates pathways linking inflamma…
View article: Biological landscape of acute illness in children in sub-Saharan Africa and South Asia
Biological landscape of acute illness in children in sub-Saharan Africa and South Asia Open
SUMMARY Childhood illnesses including pneumonia, diarrhoea and malaria are leading causes of hospitalisation and mortality in resource-limited settings. However, we lack understanding of whether systemic responses to such diverse clinical …
View article: Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort
Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort Open
Background Chronic exposure to aflatoxins is associated with liver cancer, impaired child growth, and compromised immune function. The Childhood Acute Illness and Nutrition (CHAIN) Network cohort was established to identify risk factors fo…
View article: Ancestral trajectory of infant gut microbiome assembly in non-industrialised populations
Ancestral trajectory of infant gut microbiome assembly in non-industrialised populations Open
Infant gut microbiome assembly influences childhood growth and development. However, current understanding is based almost exclusively on infants from highly industrialised, high-income countries. Here, we present a high-resolution map of …
View article: An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial protocol
An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial protocol Open
Introduction Children discharged from hospital following management of complicated severe acute malnutrition (SAM) have a high risk of mortality, readmission and failed nutritional recovery. Current management approaches fail to sufficient…
View article: Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia
Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia Open
Childhood growth can be affected by acute illness, chronic conditions, diet and their home environment. In resource-poor settings, children often experience poor growth following illness, but the mechanisms are poorly understood. This coho…
View article: Persistent Immune, Coagulation and Cardiac Dysregulation Predict Late Post-Discharge Mortality in Children with Severe Malnutrition
Persistent Immune, Coagulation and Cardiac Dysregulation Predict Late Post-Discharge Mortality in Children with Severe Malnutrition Open
View article: Genomic Atlas of Early Life Bifidobacteria for Rational Development of Next-Generation Probiotics for Infant Health
Genomic Atlas of Early Life Bifidobacteria for Rational Development of Next-Generation Probiotics for Infant Health Open
View article: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV
Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV Open
In sub-Saharan Africa, children with severe malnutrition (SM) and HIV have substantially worse outcomes than children with SM alone, facing higher mortality risk and impaired nutritional recovery post-hospitalisation. Biological mechanisms…
View article: Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial)
Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial) Open
Introduction Children with moderate or severe wasting are at particularly high risk of recurrent or persistent diarrhoea, nutritional deterioration and death following a diarrhoeal episode. Lactoferrin and lysozyme are nutritional suppleme…
View article: Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis
Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis Open
Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating …
View article: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV
Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV Open
In sub-Saharan Africa, children with severe malnutrition (SM) and comorbid HIV (HIV-SM) have substantially worse outcomes than children with SM alone, facing higher mortality risk and impaired nutritional recovery post-hospitalisation. The…
View article: Barriers and enablers to the effective implementation of omics research in low- and middle-income countries
Barriers and enablers to the effective implementation of omics research in low- and middle-income countries Open
View article: Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohort
Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohort Open
View article: Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Open
View article: Discovery and validation of plasma-based protein biomarkers for the aetiological distinction of bacterial and non-bacterial febrile infections in African children
Discovery and validation of plasma-based protein biomarkers for the aetiological distinction of bacterial and non-bacterial febrile infections in African children Open
Background In many low resource settings, the clinical management of children with febrile infections is hindered by poor access to diagnostic tools to determine whether the cause of an infection is bacterial, viral or parasitic. As a resu…
View article: Aflatoxin Exposure is Associated with Mortality in Acutely Ill Children; Results from the CHAIN Network Cohort
Aflatoxin Exposure is Associated with Mortality in Acutely Ill Children; Results from the CHAIN Network Cohort Open
View article: Linking cerebral malaria pathogenesis to APOE-mediated amyloidosis
Linking cerebral malaria pathogenesis to APOE-mediated amyloidosis Open
Although most children with cerebral malaria fully recover, about a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neur…
View article: Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Open
Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate maintenance of chronic symptom…
View article: Inflammation: the driver of poor outcomes among children with severe acute malnutrition?
Inflammation: the driver of poor outcomes among children with severe acute malnutrition? Open
Severe acute malnutrition (SAM) is the most life-threatening form of undernutrition and underlies at least 10% of all deaths among children younger than 5 years in low-income countries. SAM is a complex, multisystem disease, with physiolog…
View article: The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia
The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia Open
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may…
View article: Commentary: Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies
Commentary: Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies Open
No abstract available.
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\nA Commentary on mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies. By Michael H, Amimo JO, Rajashekara G, Saif LJ and Vlasova AN (2022). Front. Immunol. 13:8262…
View article: The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia
The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia Open
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may…
View article: The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition
The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition Open
View article: Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition
Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition Open
Children admitted to hospital with an acute illness and concurrent severe malnutrition [complicated severe malnutrition (CSM)] have a high risk of dying. The biological processes underlying their mortality are poorly understood. In this ca…
View article: Characterization of Anopheles gambiae D7 salivary proteins as markers of human–mosquito bite contact
Characterization of Anopheles gambiae D7 salivary proteins as markers of human–mosquito bite contact Open
View article: Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition
Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition Open
This was a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with C…
View article: Replication Data for: Incidence and Mortality of childhood Non-Traumatic Coma of Unknown Cause in Kilifi County between 2002 to 2018
Replication Data for: Incidence and Mortality of childhood Non-Traumatic Coma of Unknown Cause in Kilifi County between 2002 to 2018 Open
This is a replication data package for the manuscript titled: "Incidence and Mortality of childhood Non-Traumatic Coma of Unknown Cause in Kilifi County between 2002 to 2018." This is a secondary analysis of data from children aged 2 month…
View article: Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor
Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor Open
This is a replication dataset for the manuscript titled: "Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor." Our aim was to determine albumin-independent differences in pathophysiology between Severe wasting and…