James G. Marks
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View article: Poison Ivy Dermatitis Treatment Patterns and Utilization: A Retrospective Claims-based Analysis
Poison Ivy Dermatitis Treatment Patterns and Utilization: A Retrospective Claims-based Analysis Open
Introduction: Poison ivy (toxicodendron) dermatitis (TD) resulting from contact with poison ivy, oak, or sumac is a common form of allergic contact dermatitis that impacts millions of people in the United State every year and results in an…
View article: Safety Assessment of Bovine Milk Proteins and Protein Derivatives as Used in Cosmetics
Safety Assessment of Bovine Milk Proteins and Protein Derivatives as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 16 bovine milk proteins and protein-derived ingredients, which function mainly as skin and hair conditioning agents in personal care products. The Panel reviewe…
View article: Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 80 Citrus fruit-derived ingredients, which are most frequently reported to function in cosmetics as fragrances and/or skin-conditioning agents. The Panel review…
View article: Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of the mixture Methylchloroisothiazolinone (MCI)/Methylisothiazolinone (MI), which functions as a preservative in cosmetic products. The Panel reviewed relevant …
View article: Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics
Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Phosphoric Acid and its salts (31 ingredients), which are reported to function as buffering agents, corrosion inhibitors, chelating agents, and pH adjusters in …
View article: Final Amended Safety Assessment of Sodium Sulfate as Used in Cosmetics
Final Amended Safety Assessment of Sodium Sulfate as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) reopened the safety assessment of Sodium Sulfate, a cosmetic ingredient that is an inorganic salt reported to function in cosmetics as a viscosity increasing agent—aqueous. The Panel …
View article: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics Open
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, a…
View article: Table 1. Common Sources Associated with the Top 10 NACDG Allergens, Currently Relevant Supplemental (non-NACDG) Allergens, and Irritant Contact Dermatitis
Table 1. Common Sources Associated with the Top 10 NACDG Allergens, Currently Relevant Supplemental (non-NACDG) Allergens, and Irritant Contact Dermatitis Open
Mendeley Supplementary Table 1. Common Sources Associated with the Top 10 NACDG Allergens, Currently Relevant Supplemental (non-NACDG) Allergens, and Irritant Contact Dermatitis Allergen Sources Personal care products were the most common …
View article: Evaluation of Patch Test Findings in Patients With Anogenital Dermatitis
Evaluation of Patch Test Findings in Patients With Anogenital Dermatitis Open
For patients with anogenital involvement only who were referred for patch testing, male patients were more likely to have allergic contact dermatitis, whereas female patients were more likely to have other dermatoses. Common allergens or s…
View article: Facial Dermatitis in Male Patients Referred for Patch Testing
Facial Dermatitis in Male Patients Referred for Patch Testing Open
Although many allergens were similar in both groups, MFD were more likely to react to use of dimethylaminopropylamine and paraphenylenediamine, presumably owing to their higher prevalence in hair products. Most sources of allergic and irri…
View article: Safety Assessment of <i>Avena sativa</i> (Oat)-Derived Ingredients As Used in Cosmetics
Safety Assessment of <i>Avena sativa</i> (Oat)-Derived Ingredients As Used in Cosmetics Open
This is a safety assessment of Avena sativa (oat)–derived ingredients. The reported functions of these ingredients in cosmetics include abrasives, antioxidant, skin conditioning agents, absorbents, and bulking agents. The Panel reviewed re…
View article: Safety Assessment of <i>Camellia sinensis–</i>Derived Ingredients As Used in Cosmetics
Safety Assessment of <i>Camellia sinensis–</i>Derived Ingredients As Used in Cosmetics Open
Cosmetic ingredients derived from Camellia sinensis (tea) plant parts function as antioxidants and skin conditioning agents—humectant and miscellaneous. The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed relevant animal and…
View article: Safety Assessment of Sorbitan Esters as Used in Cosmetics
Safety Assessment of Sorbitan Esters as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 20 sorbitan esters; this report included sorbitan esters that were reviewed in 1985 and 2002, as well as 3 previously unreviewed sorbitan esters (sorbitan undecylen…
View article: Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics
Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of fatty acid amidopropyl dimethylamines, which function primarily as antistatic agents in cosmetic products. The relevant animal and human data reviewed for these ing…
View article: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics
Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 25 monosaccharides, disaccharides, and related ingredients and concluded these are safe in the present practices of use and concentration described in the safety as…
View article: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previou…
View article: Safety Assessment of Pentaerythrityl Tetra-Di<i>-t-</i>Butyl Hydroxyhydrocinnamate as Used in Cosmetics
Safety Assessment of Pentaerythrityl Tetra-Di<i>-t-</i>Butyl Hydroxyhydrocinnamate as Used in Cosmetics Open
Pentaerythrityl tetra-di -t-butyl hydroxyhydrocinnamate functions as an antioxidant in cosmetic products and is used at concentrations up to 0.8%. Given the high molecular weight of this ingredient, skin penetration is not likely. The avai…
View article: Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics
Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics Open
Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 function primarily as skin conditioning agents, and Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Tripeptide-1, Copper Tripeptide-…
View article: Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics
Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel assessed the safety of 47 polyethylene glycols (PEGs) cocamine and related ingredients, which are reported to function mostly as surfactants and antistatic agents. The Panel reviewed the relevant…
View article: Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics
Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics Open
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of tromethamine, aminomethyl propanediol, and aminoethyl propanediolas used in cosmetics. All 3 ingredients are reported to function in cosmetics as pH adjusters…
View article: Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics
Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics Open
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel deter…
View article: Safety Assessment of Magnesium Sulfate as Used in Cosmetics
Safety Assessment of Magnesium Sulfate as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of magnesium sulfate, which functions as a bulking agent in cosmetic products and is reportedly used at concentrations up to 11% and 25% in leave-on and rinse-off prod…
View article: Safety Assessment of Alkyl Betaines as Used in Cosmetics
Safety Assessment of Alkyl Betaines as Used in Cosmetics Open
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 11 alkyl betaines as used in cosmetics. These ingredients are reported to function as hair and skin conditioning agents, antistatic agents, surfactants-cleansing ag…
View article: Safety Assessment of Plant-Derived Fatty Acid Oils
Safety Assessment of Plant-Derived Fatty Acid Oils Open
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 244 plant-derived fatty acid oils as used in cosmetics. Oils are used in a wide variety of cosmetic products for their skin conditioning, occlusive, emollient, and …
View article: Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate
Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate Open
Benzyl alcohol, benzoic acid and its salts, and benzyl benzoate function mostly as fragrance ingredients/preservatives in cosmetic products. The Cosmetic Ingredient Review Expert Panel previously established concentration limits for benzyl…
View article: Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics
Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics Open
Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingre…