James Mason
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View article: Vancomycin Exposure is Associated with Protection from Acute Graft-vs-Host Disease (aGVHD) Through Microbiome-dependent Mechanisms
Vancomycin Exposure is Associated with Protection from Acute Graft-vs-Host Disease (aGVHD) Through Microbiome-dependent Mechanisms Open
Backgound Enterococcu s and Akkermansia species enhance immune function through T-cell dependent mechanisms. This suggests vancomycin exposure and consequently the relative abundance of Enterococcus may have repercussions on immune-related…
View article: Identification of clinical, laboratory, and epidemiological characteristics to accelerate diagnosis of Crimean-Congo Hemorrhagic Fever in patients presenting to health centres in low-resource endemic settings: a systematic literature review
Identification of clinical, laboratory, and epidemiological characteristics to accelerate diagnosis of Crimean-Congo Hemorrhagic Fever in patients presenting to health centres in low-resource endemic settings: a systematic literature review Open
Background Crimean-Congo Hemorrhagic Fever (CCHF) is a viral hemorrhagic fever caused by an orthonairovirus transmitted to humans by infected ticks. The incidence of CCHF is vastly underestimated, in part due to frequent misdiagnosis and p…
View article: Dynamical patterns and nonreciprocal effective interactions in an active-passive mixture through exact hydrodynamic analysis
Dynamical patterns and nonreciprocal effective interactions in an active-passive mixture through exact hydrodynamic analysis Open
The formation of dynamical patterns is one of the most striking features of nonequilibrium physical systems. Recent work has shown that such patterns arise generically from forces that violate Newton’s third law, known as nonreciprocal int…
View article: Cost utility analysis of acute rehabilitation approaches in the management of traumatic anterior shoulder dislocation
Cost utility analysis of acute rehabilitation approaches in the management of traumatic anterior shoulder dislocation Open
Aims We aimed to conduct a cost-utility analysis comparing one session of advice, supporting materials, and option to self-refer to physiotherapy with the same advice and materials, plus an additional programme of physiotherapy for people …
View article: Two-Year Follow-up of a Group-Sequential, Multicenter Randomized Controlled Trial of a Subacromial Balloon Spacer for Irreparable Rotator Cuff Tears of the Shoulder (START:REACTS)
Two-Year Follow-up of a Group-Sequential, Multicenter Randomized Controlled Trial of a Subacromial Balloon Spacer for Irreparable Rotator Cuff Tears of the Shoulder (START:REACTS) Open
Background: The best management of irreparable rotator cuff tears remains uncertain, with multiple new techniques introduced over the past 2 decades. Two options for treatment are arthroscopic debridement and biceps tenotomy, or the subacr…
View article: A complex ePrescribing antimicrobial stewardship-based (ePAMS+) intervention for hospitals: mixed-methods feasibility trial results
A complex ePrescribing antimicrobial stewardship-based (ePAMS+) intervention for hospitals: mixed-methods feasibility trial results Open
View article: Dynamical patterns and nonreciprocal effective interactions in an active-passive mixture through exact hydrodynamic analysis
Dynamical patterns and nonreciprocal effective interactions in an active-passive mixture through exact hydrodynamic analysis Open
The formation of dynamical patterns is one of the most striking features of nonequilibrium physical systems. Recent work has shown that such patterns arise generically from forces that violate Newton's third law, known as nonreciprocal int…
View article: Infographic: Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures
Infographic: Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures Open
View article: Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures
Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures Open
Aims The aim of this trial was to assess the cost-effectiveness of a soft bandage and immediate discharge, compared with rigid immobilization, in children aged four to 15 years with a torus fracture of the distal radius. Methods A within-t…
View article: A protocol for the conduct of a multicentre, prospective, randomized superiority trial of surgical versus non-surgical interventions for humeral shaft fractures
A protocol for the conduct of a multicentre, prospective, randomized superiority trial of surgical versus non-surgical interventions for humeral shaft fractures Open
Aims Fractures of the humeral shaft represent 3% to 5% of all fractures. The most common treatment for isolated humeral diaphysis fractures in the UK is non-operative using functional bracing, which carries a low risk of complications, but…
View article: Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: A pragmatic randomised triaL (VITAL)
Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: A pragmatic randomised triaL (VITAL) Open
Background Improving outcomes after surgery is a major public health research priority for patients, clinicians and the NHS. The greatest burden of perioperative complications, mortality and healthcare costs lie amongst the population of p…
View article: Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial
Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial Open
Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve health related quality of life compared with usual care in adults with post-covid-19 condition (long covid).…
View article: Protocol for Surgery or Cast of the EpicoNdyle in Children’s Elbows (SCIENCE)
Protocol for Surgery or Cast of the EpicoNdyle in Children’s Elbows (SCIENCE) Open
Aims The management of fractures of the medial epicondyle is one of the greatest controversies in paediatric fracture care, with uncertainty concerning the need for surgery. The British Society of Children’s Orthopaedic Surgery prioritized…
View article: Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial
Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial Open
Objective To assess the effects of an additional programme of physiotherapy in adults with a first-time traumatic shoulder dislocation compared with single session of advice, supporting materials, and option to self-refer to physiotherapy.…
View article: Microbial Warriors: Using Predatory Bacteria to Combat Pathogens
Microbial Warriors: Using Predatory Bacteria to Combat Pathogens Open
View article: The development of a complex digital and behavioural Antimicrobial Stewardship intervention for hospitals in England
The development of a complex digital and behavioural Antimicrobial Stewardship intervention for hospitals in England Open
Background Computerised prescribing systems, which are becoming widely adopted, have the potential to improve antimicrobial stewardship, but often lack relevant in-built components to optimally facilitate good antimicrobial stewardship pra…
View article: Exact hydrodynamics and onset of phase separation for an active exclusion process
Exact hydrodynamics and onset of phase separation for an active exclusion process Open
We consider a lattice model of active matter with exclusion and derive its hydrodynamic description exactly. The hydrodynamic limit leads to an integro-differential equation for the density of particles with a given orientation. Volume exc…
View article: Randomised trial of the clinical and cost effectiveness of a supraglottic airway device compared with tracheal intubation for in-hospital cardiac arrest (AIRWAYS-3): Protocol, design and implementation
Randomised trial of the clinical and cost effectiveness of a supraglottic airway device compared with tracheal intubation for in-hospital cardiac arrest (AIRWAYS-3): Protocol, design and implementation Open
View article: Use of cast immobilization versus removable brace in adults with an ankle fracture: two-year follow-up of a multicentre randomized controlled trial
Use of cast immobilization versus removable brace in adults with an ankle fracture: two-year follow-up of a multicentre randomized controlled trial Open
Aims The aim of this study was to compare the longer-term outcomes of operatively and nonoperatively managed patients treated with a removable brace (fixed-angle removable orthosis) or a plaster cast immobilization for an acute ankle fract…
View article: pyOpenSci/software-peer-review: Release v0.5 - reorganization and cleanup of guide
pyOpenSci/software-peer-review: Release v0.5 - reorganization and cleanup of guide Open
Also moved to pydata_sphinx_theme!
View article: Expanding SPTAN1 monoallelic variant associated disorders: From epileptic encephalopathy to pure spastic paraplegia and ataxia
Expanding SPTAN1 monoallelic variant associated disorders: From epileptic encephalopathy to pure spastic paraplegia and ataxia Open
View article: Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs
Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs Open
Background Assessing the long term effects of many surgical interventions tested in pragmatic RCTs may require extended periods of participant follow-up to assess effectiveness and use patient-reported outcomes that require large sample si…
View article: Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK
Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK Open
UK National Institute for Health and Care Research.
View article: Cost-utility analysis of cast compared to removable brace in the management of adult patients with ankle fractures
Cost-utility analysis of cast compared to removable brace in the management of adult patients with ankle fractures Open
Aims To compare the cost-utility of removable brace compared with cast in the management of adult patients with ankle fracture. Methods A within-trial economic evaluation conducted from the UK NHS and personnel social services (PSS) perspe…
View article: Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study
Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study Open
Introduction People who sustain a hip fracture are typically elderly, frail and require urgent surgery. Hip fracture and the urgent surgery is associated with acute blood loss, compounding patients’ pre-existing comorbidities including ana…
View article: Stepped-wedge randomized controlled trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation
Stepped-wedge randomized controlled trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation Open
View article: A complex ePrescribing-based Anti-Microbial Stewardship (ePAMS+) intervention for hospitals combining technological and behavioural components: protocol for a feasibility trial
A complex ePrescribing-based Anti-Microbial Stewardship (ePAMS+) intervention for hospitals combining technological and behavioural components: protocol for a feasibility trial Open
Introduction Antimicrobial resistance is a leading global public health threat, with inappropriate use of antimicrobials in healthcare contributing to its development. Given this urgent need, we developed a complex ePrescribing-based Anti-…
View article: Macroscopic behaviour in a two-species exclusion process via the method of matched asymptotics
Macroscopic behaviour in a two-species exclusion process via the method of matched asymptotics Open
We consider a two-species simple exclusion process on a periodic lattice. We use the method of matched asymptotics to derive evolution equations for the two population densities in the dilute regime, namely a cross-diffusion system of part…
View article: “Sugar or Salt” (SOS) trial protocol summary
“Sugar or Salt” (SOS) trial protocol summary Open
Objective: Does hyperosmolar therapy (mannitol or hypertonic saline) in traumatic brain injury (TBI) improve neurological function clinically and cost- effectively at 6 months?
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\nDesign: Multi-centre, open label, randomised controlled c…
View article: TP6.1.5 The Importance of the Patient Voice in Metastatic Colorectal Cancer: A Qualitative Study
TP6.1.5 The Importance of the Patient Voice in Metastatic Colorectal Cancer: A Qualitative Study Open
Aims Colorectal cancer is the fourth commonest cancer in the UK with a third presenting with synchronous liver metastases. Although there is a large body of clinical cohort data, there is no research exploring patient perspectives of disea…