Pavel Matousek
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View article: Feasibility of diffuse Raman spectroscopy to detect in-vivo molecular changes in the tissue induced by subcutaneous implants
Feasibility of diffuse Raman spectroscopy to detect in-vivo molecular changes in the tissue induced by subcutaneous implants Open
Biomaterials are being designed for a broad range of medical applications, but regardless of their endpoint use, they trigger host immune responses, also known as foreign body responses (FBR). This study investigates the feasibility of usi…
View article: Impact and mitigation of near infrared absorption in quantitative Transmission Raman Spectroscopy
Impact and mitigation of near infrared absorption in quantitative Transmission Raman Spectroscopy Open
Transmission Raman Spectroscopy is an analytical technique commonly used for uniformity content analysis of manufactured pharmaceutical products to quantify the active pharmaceutical ingredients and excipients in the final formulation. Suc…
View article: Simple and rapid low-cost assays to investigate ethylene glycol and diethylene glycol contamination in raw materials and medicinal syrups
Simple and rapid low-cost assays to investigate ethylene glycol and diethylene glycol contamination in raw materials and medicinal syrups Open
There have been hundreds of child deaths due to contamination of medicinal syrups with diethylene glycol (DEG) and ethylene glycol (EG). Detection of DEG and EG is usually performed by gas chromatography, a method that is costly, laborious…
View article: Handheld Spatially Offset Raman Spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups
Handheld Spatially Offset Raman Spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups Open
We investigate the potential of Spatially Offset Raman Spectroscopy (SORS) as a rapid, non-invasive screening tool deployable in the field to detect diethylene glycol (DEG) and ethylene glycol (EG) in medicinal syrups within closed contain…
View article: An All-in-One Nanoheater and Optical Thermometer Fabricated from Fractal Nanoparticle Assemblies
An All-in-One Nanoheater and Optical Thermometer Fabricated from Fractal Nanoparticle Assemblies Open
We designed and optimized a dual-functional photothermal agent that performs as a nanoheater and real-time optical thermometer by leveraging gold nanoparticle (AuNP) self-assembly and anti-Stokes thermometry. We engineered colloidally stab…
View article: Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges Open
The year 2024 marks the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity …
View article: Noninvasive Characterization of Preservation Fluids through Glass Container Using Spatially Offset Raman Spectroscopy: Potential in Heritage Science
Noninvasive Characterization of Preservation Fluids through Glass Container Using Spatially Offset Raman Spectroscopy: Potential in Heritage Science Open
The conservation and characterization of preservation fluids are crucial for maintaining specimen integrity in natural history fluid collections. However, characterizing these fluids analytically poses significant challenges, especially as…
View article: Developing a New Testing Methodology for Honey Authentication
Developing a New Testing Methodology for Honey Authentication Open
Honey is a valuable and nutritious food product, and its popularity is increasing globally driven by consumers demand for a healthier and more sustainable diet. However, honey is at risk of fraudulent practices such as the addition of exog…
View article: Gold Nanoraspberries for Surface-Enhanced Raman Scattering: Synthesis, Optimization, and Characterization
Gold Nanoraspberries for Surface-Enhanced Raman Scattering: Synthesis, Optimization, and Characterization Open
In this work, we demonstrate the synthesis of gold nanoraspberries (AuNRB) using a HEPES buffer at room temperature. The study aimed to identify and compare the physicochemical conditions of the AuNRB and gold nanospheres (AuNS) of similar…
View article: Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues
Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues Open
Many different types of nanoparticles have been developed for photothermal therapy (PTT), but directly comparing their efficacy as heaters and determining how they will perform when localized at depth in tissue remains complex. To choose t…
View article: Shifted-excitation Raman difference spectroscopy and charge-shifting detection coupled with spatially offset Raman spectroscopy for heritage science
Shifted-excitation Raman difference spectroscopy and charge-shifting detection coupled with spatially offset Raman spectroscopy for heritage science Open
SERDS and charge-shifting technologies can be combined with SORS for the non-invasive in situ investigations of the subsurface of cultural heritage materials while simultaneously rejecting ambient light and fluorescence interfering contrib…
View article: Unravelling hidden text and figures in paper-based archival documents with micro-spatially offset Raman spectroscopy imaging
Unravelling hidden text and figures in paper-based archival documents with micro-spatially offset Raman spectroscopy imaging Open
The preservation of paper-based archival documents is crucial for safeguarding historical and cultural heritage. Some records possess visually inaccessible text or images because of previous conservation measures, their method of construct…
View article: Theoretical and Practical Considerations of Spatially Offset Raman Spectroscopy (SORS) and Micro-SORS
Theoretical and Practical Considerations of Spatially Offset Raman Spectroscopy (SORS) and Micro-SORS Open
Spatially offset Raman spectroscopy (SORS) is typically used to non-invasively investigate stratified samples that possess features on a millimeter scale, whereas micro-SORS usually deals with micrometer-thick layered samples. However, the…
View article: Active Surface-Enhanced Raman Spectroscopy (SERS): A Novel Concept for Enhancing Signal Contrast in Complex Matrices Using External Perturbation
Active Surface-Enhanced Raman Spectroscopy (SERS): A Novel Concept for Enhancing Signal Contrast in Complex Matrices Using External Perturbation Open
Noninvasive detection of surface-enhanced Raman spectroscopy (SERS) signals from deep within tissue represents a common challenge in many biological and clinical applications including disease diagnosis and therapy monitoring. Such signals…
View article: Application of Spatial Offset Raman Spectroscopy (SORS) and Machine Learning for Sugar Syrup Adulteration Detection in UK Honey
Application of Spatial Offset Raman Spectroscopy (SORS) and Machine Learning for Sugar Syrup Adulteration Detection in UK Honey Open
Honey authentication is a complex process which traditionally requires costly and time-consuming analytical techniques not readily available to the producers. This study aimed to develop non-invasive sensor methods coupled with a multivari…
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View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Advanced portable micro-SORS prototype coupled with SERDS for heritage science
Advanced portable micro-SORS prototype coupled with SERDS for heritage science Open
Development of an advanced portable micro-SORS prototype combined with SERDS.
View article: Raman spectroscopy advancements in heritage science
Raman spectroscopy advancements in heritage science Open
Micro-Spatially Offset Raman Spectroscopy (micro-SORS) is an advanced Raman technique that allows the non-destructive analysis of inner portions of cultural heritage artefacts, providing insights on their composition in a non-destructive w…
View article: Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte
Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte Open
Here we propose Guided PCA, a simple approach to ensure the spectrum of a key target moiety is consistly provided in a high ranking principal component.
View article: Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model
Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model Open
Diffuse Raman spectroscopy (DRS) allows subsurface molecular analysis of optically turbid samples. Numerical modeling of light propagation was used as a method for improving the design of an DRS instrument to maximize the signal to noise r…