James Mukiibi
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View article: Long-term risk of tuberculosis among individuals with Xpert Ultra trace screening results in Uganda: a longitudinal follow-up study
Long-term risk of tuberculosis among individuals with Xpert Ultra trace screening results in Uganda: a longitudinal follow-up study Open
National Institutes of Health and the Gates Foundation.
View article: Evaluating Smartphone-Based Cough Monitoring for Tuberculosis Screening and Triage in Uganda: A Mixed-Methods Evaluation
Evaluating Smartphone-Based Cough Monitoring for Tuberculosis Screening and Triage in Uganda: A Mixed-Methods Evaluation Open
Symptom-based tuberculosis (TB) screening often relies on cough reporting, which may be unreliable. Passive cough monitoring via smartphone apps offers a less subjective alternative. This study evaluated the diagnostic accuracy and impleme…
View article: Diagnostic accuracy of tongue swab testing in persons with sputum Xpert Ultra Trace results
Diagnostic accuracy of tongue swab testing in persons with sputum Xpert Ultra Trace results Open
Background Molecular amplification of tongue swab samples is a non-sputum-based investigational approach to diagnose pulmonary tuberculosis (pTB). An improved manual qPCR method for tongue swabs recently achieved >90% sensitivity overall i…
View article: Patient experiences of tuberculosis treatment deferral after a trace Xpert Ultra result: a prospective cohort study
Patient experiences of tuberculosis treatment deferral after a trace Xpert Ultra result: a prospective cohort study Open
Background A “trace” result from the Xpert Ultra molecular tuberculosis test indicates Mycobacterium tuberculosis DNA detection but may not always signify tuberculosis disease. Little is known about the experiences of individuals with trac…
View article: Cumulative TB disease burden following sputum Xpert Ultra ‘Trace’ results in clinical settings: Results from a multi-site observational clinical study
Cumulative TB disease burden following sputum Xpert Ultra ‘Trace’ results in clinical settings: Results from a multi-site observational clinical study Open
Background Highly sensitive molecular tests, like Xpert Ultra, are reshaping TB diagnosis—detecting paucibacillary TB but sometimes creating uncertainty when they detect DNA in extremely low quantities that may not signal disease. This amb…
View article: The long-term risk of tuberculosis among individuals with Xpert Ultra “trace” screening results: a longitudinal follow-up study
The long-term risk of tuberculosis among individuals with Xpert Ultra “trace” screening results: a longitudinal follow-up study Open
Summary Background Systematic screening for tuberculosis using Xpert Ultra generates “trace” results of uncertain significance. Additional microbiological testing in this context is often negative, but untreated individuals might still pro…
View article: P-766. Patient Experiences of Deferring Treatment for Further Evaluation and Monitoring after a Trace Xpert Ultra Result
P-766. Patient Experiences of Deferring Treatment for Further Evaluation and Monitoring after a Trace Xpert Ultra Result Open
Background For people with “trace” sputum results (PWTS) on Xpert MTB/RIF Ultra, further evaluation and monitoring rather than reflex TB treatment may be appropriate. Patients’ preferences regarding treatment deferral have not been explore…
View article: Patient Experiences of Treatment Deferral for Evaluation and Monitoring after a Trace Xpert Ultra Result
Patient Experiences of Treatment Deferral for Evaluation and Monitoring after a Trace Xpert Ultra Result Open
Background A “trace” result from the Xpert Ultra molecular TB test indicates Mycobacterium tuberculosis DNA detection but may not always signify TB disease. Little is known about the experiences of individuals with trace results who are no…
View article: The potential yield of geographically targeted tuberculosis contact investigation in urban Uganda
The potential yield of geographically targeted tuberculosis contact investigation in urban Uganda Open
We investigated the potential yield of conducting active case finding for tuberculosis (TB) within a defined geographic radius (50 or 100 m) around the households of individuals diagnosed with TB at health facilities. In a well-defined geo…
View article: Accuracy of C-Reactive Protein for Tuberculosis Detection in General-Population Screening and Ambulatory-Care Triage in Uganda
Accuracy of C-Reactive Protein for Tuberculosis Detection in General-Population Screening and Ambulatory-Care Triage in Uganda Open
Rationale: C-reactive protein (CRP) has demonstrated utility as a point-of-care triage test for tuberculosis (TB) in clinical settings, particularly among people with human immunodeficiency virus (HIV), but its performance for gener…
View article: Decline in prevalence of tuberculosis following an intensive case finding campaign and the COVID-19 pandemic in an urban Ugandan community
Decline in prevalence of tuberculosis following an intensive case finding campaign and the COVID-19 pandemic in an urban Ugandan community Open
Background Systematic screening is a potential tool for reducing the prevalence of tuberculosis (TB) and counteracting COVID-19-related disruptions in care. Repeated community-wide screening can also measure changes in the prevalence of TB…
View article: Evidence for Tuberculosis in Individuals With Xpert Ultra “Trace” Sputum During Screening of High-Burden Communities
Evidence for Tuberculosis in Individuals With Xpert Ultra “Trace” Sputum During Screening of High-Burden Communities Open
Background “Trace” results on Xpert MTB/RIF Ultra (“Ultra”; Cepheid) —a molecular diagnostic test for tuberculosis (TB)—are often interpreted as an indication for TB treatment, but may also represent detection of nonviable bacilli or analy…
View article: Higher yield using an event-based vs. door-to-door approach for active case-finding for TB
Higher yield using an event-based vs. door-to-door approach for active case-finding for TB Open
View article: Decline in prevalence of tuberculosis following an intensive case-finding campaign and the COVID-19 pandemic in an urban Ugandan community
Decline in prevalence of tuberculosis following an intensive case-finding campaign and the COVID-19 pandemic in an urban Ugandan community Open
Background Systematic screening is a potential tool for reducing the prevalence of tuberculosis and counteracting COVID-related disruptions in care. Repeated community-wide screening can also measure changes in the prevalence of tuberculos…
View article: Cost to perform door-to-door universal sputum screening for TB in a high-burden community
Cost to perform door-to-door universal sputum screening for TB in a high-burden community Open
BACKGROUND: Population-based active case-finding (ACF) identifies people with TB in communities but can be costly. METHODS: We conducted an empiric costing study within a door-to-door household ACF campaign in an urban community in Uganda,…
View article: The impact of time at home on potential yield of home-based TB contact investigation
The impact of time at home on potential yield of home-based TB contact investigation Open
BACKGROUND: The yield of TB contact tracing is often limited by challenges in reaching individuals during the screening process. We investigated the times at which index patients and household contacts were typically at home and the potent…
View article: Accuracy of C-Reactive Protein for General-Population Tuberculosis Screening in a Community Setting and Triage in Ambulatory Care Settings in Kampala, Uganda
Accuracy of C-Reactive Protein for General-Population Tuberculosis Screening in a Community Setting and Triage in Ambulatory Care Settings in Kampala, Uganda Open
View article: Low prevalence of diabetes mellitus in TB patients and the community in urban Uganda
Low prevalence of diabetes mellitus in TB patients and the community in urban Uganda Open
View article: Spatial distribution of TB among individuals with a history of incarceration
Spatial distribution of TB among individuals with a history of incarceration Open
View article: Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda
Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda Open
Background International and internal migration are recognized risk factors for tuberculosis (TB). Geographic mobility, including travel for work, education, or personal reasons, may also play a role in TB transmission, but this relationsh…
View article: Data and code associated with the publication: Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda
Data and code associated with the publication: Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda Open
This dataset is an anonymized subset of the data collected by the STOMP-TB study (A Comprehensive Snapshot of Tuberculosis Transmission in an Urban Ugandan Community). The dataset includes records from: 1. patients who were diagnosed with …
View article: Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis
Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis Open
Background When evaluating symptomatic patients for tuberculosis (TB) without access to same-day diagnostic test results, clinicians often make empiric decisions about starting treatment. The number of TB symptoms and/or underweight status…
View article: The Spectrum of Tuberculosis Disease in an Urban Ugandan Community and Its Health Facilities
The Spectrum of Tuberculosis Disease in an Urban Ugandan Community and Its Health Facilities Open
Background New, sensitive diagnostic tests facilitate identification and investigation of milder forms of tuberculosis (TB) disease. We used community-based TB testing with the Xpert MTB/RIF Ultra assay (“Ultra”) to characterize individual…
View article: Spatial distribution of people diagnosed with tuberculosis through routine and active case finding: a community-based study in Kampala, Uganda
Spatial distribution of people diagnosed with tuberculosis through routine and active case finding: a community-based study in Kampala, Uganda Open
View article: Data associated with the publication: Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis
Data associated with the publication: Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis Open
This dataset is an anonymized subset of the data collected by the STOMP-TB study (A Comprehensive Snapshot of Tuberculosis Transmission in an Urban Ugandan Community). The included records are from patients who were diagnosed with pulmonar…
View article: Empiric treatment of pulmonary TB in the Xpert era: Correspondence of sputum culture, Xpert MTB/RIF, and clinical diagnoses
Empiric treatment of pulmonary TB in the Xpert era: Correspondence of sputum culture, Xpert MTB/RIF, and clinical diagnoses Open
Judged against sputum culture in a routine care setting of high HIV prevalence, the accuracy of Xpert was high. Clinical judgment identified a small number of additional culture-positive cases, but with poor specificity. Although clinician…
View article: Nutritional and physicochemical properties of stored solar-dried cowpea leafy vegetables
Nutritional and physicochemical properties of stored solar-dried cowpea leafy vegetables Open
Preservation techniques for cowpea (Vigna unguiculata L.) leaves, a green leafy vegetable mainly consumed in the eastern and northern parts of Uganda, are still lacking. The study aimed at determining the effect of blanching, open sun and …