James N. Scott
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View article: Excised DNA circles from V(D)J recombination promote relapsed leukaemia
Excised DNA circles from V(D)J recombination promote relapsed leukaemia Open
View article: Consensus Approach for Standardization of the Timing of Brain Magnetic Resonance Imaging and Classification of Brain Injury in Neonates With Neonatal Encephalopathy/Hypoxic-Ischemic Encephalopathy: A Canadian Perspective
Consensus Approach for Standardization of the Timing of Brain Magnetic Resonance Imaging and Classification of Brain Injury in Neonates With Neonatal Encephalopathy/Hypoxic-Ischemic Encephalopathy: A Canadian Perspective Open
Once validated, the proposed radiological classification and scoring system can be applied across centers to facilitate consistent outcome comparisons, improve prognostication for neonates with NE/HIE, and enhance the quality of family cou…
View article: Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity
Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity Open
One of the most prominent symptoms in multiple sclerosis is pathological fatigue, often described by sufferers as one of the most debilitating symptoms, affecting quality of life and employment. However, the mechanisms of both, physical an…
View article: Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation
Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation Open
Transcription enhancers are essential activators of V(D)J recombination that orchestrate non-coding transcription through complementary, unrearranged gene segments. How transcription is coordinately increased at spatially distinct promoter…
View article: A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins
A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins Open
Broadly neutralizing antibodies have huge potential as novel antiviral therapeutics due to their ability to recognize highly conserved epitopes that are seldom mutated in viral variants. A subset of bovine antibodies possess an ultralong c…
View article: 24 Persistent pulmonary hypertension and short-term neurological outcomes in infants with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia
24 Persistent pulmonary hypertension and short-term neurological outcomes in infants with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia Open
Background Neonatal hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia is a serious clinical condition that may result in permanent neurologic deficits or death. There is an increased incidence of persistent pulmonary hypertens…
View article: An Ultralong Bovine CDRH3 that Targets a Conserved, Cryptic Epitope on SARS-CoV and SARS-CoV-2
An Ultralong Bovine CDRH3 that Targets a Conserved, Cryptic Epitope on SARS-CoV and SARS-CoV-2 Open
The ability of broadly neutralising antibodies to target conserved epitopes gives them huge potential as antibody-based therapeutics, particularly in the face of constant viral antigen evolution. Certain bovine antibodies are highly adept …
View article: Pneumococcal otogenic meningitis complicated by pneumocephalus, seizures, right-sided hemiplegia and cortical venous thrombosis
Pneumococcal otogenic meningitis complicated by pneumocephalus, seizures, right-sided hemiplegia and cortical venous thrombosis Open
View article: Neuroprotection Care Bundle Implementation is Associated with Improved Long-Term Neurodevelopmental Outcomes in Extremely Premature Infants
Neuroprotection Care Bundle Implementation is Associated with Improved Long-Term Neurodevelopmental Outcomes in Extremely Premature Infants Open
View article: Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective
Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective Open
Acquired brain injury remains common in very preterm infants and is associated with significant risks for short- and long-term morbidities. Cranial ultrasound has been widely adopted as the first-line neuroimaging modality to study the neo…
View article: Cognitive fatigue in multiple sclerosis is associated with alterations in the functional connectivity of monoamine circuits
Cognitive fatigue in multiple sclerosis is associated with alterations in the functional connectivity of monoamine circuits Open
Fatigue is a highly prevalent and debilitating symptom in multiple sclerosis, but currently the available treatment options have limited efficacy. The development of innovative and efficacious targeted treatments for fatigue in multiple sc…
View article: Impact of outreach education program on outcomes of neonates with hypoxic ischemic encephalopathy
Impact of outreach education program on outcomes of neonates with hypoxic ischemic encephalopathy Open
Aim To evaluate the impact of outreach education targeting neuroprotection on outcomes of outborn infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Methods A retrospective cohort study of infants admitted with moderate…
View article: Preferences of nursing and medical students for working with older adults and people with dementia: a systematic review
Preferences of nursing and medical students for working with older adults and people with dementia: a systematic review Open
Background A current issue in workforce planning is ensuring healthcare professionals are both competent and willing to work with older adults with complex needs. This includes dementia care, which is widely recognised as a priority. Yet r…
View article: Systematic review of the etiology behind patellar clunk syndrome
Systematic review of the etiology behind patellar clunk syndrome Open
The etiology of PCS is multifactorial, owing to the growing metrics that have associations with its incidence. This conclusion is validated by the significance of prosthesis design as the most likely parameter involved in developing PCS si…
View article: Adult New Onset Gelastic Seizures of Cortical Origin
Adult New Onset Gelastic Seizures of Cortical Origin Open
View article: Intraventricular Hemorrhage: Risk Factors and Association With Patent Ductus Arteriosus Treatment in Extremely Preterm Neonates
Intraventricular Hemorrhage: Risk Factors and Association With Patent Ductus Arteriosus Treatment in Extremely Preterm Neonates Open
Objectives: To assess maternal and neonatal risk factors for intraventricular hemorrhage (IVH). To examine the association of patent ductus arteriosus (PDA) and its treatment, with IVH and its severity. Study design: In this …
View article: The ESC: The Dangerous By-Product of V(D)J Recombination
The ESC: The Dangerous By-Product of V(D)J Recombination Open
V(D)J recombination generates antigen receptor diversity by mixing and matching individual variable (V), diversity (D), and joining (J) gene segments. An obligate by-product of many of these reactions is the excised signal circle (ESC), ge…
View article: Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability
Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability Open
V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single recombination sign…
View article: P.013 Convulsive status epilepticus due to intracranial hypotension
P.013 Convulsive status epilepticus due to intracranial hypotension Open
Background: Intracranial hypotension (IH) is typically characterized by an orthostatic headache. There have been limited case reports describing iatrogenic IH presenting with seizures. Methods: Case report. Results: A 71-year-old woman wit…
View article: SURG-15. INTEGRATING MOLECULAR MARKERS AND EXTENT OF RESECTION FOR RISK STRATIFICATION OF PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA: A MULTICENTRE STUDY
SURG-15. INTEGRATING MOLECULAR MARKERS AND EXTENT OF RESECTION FOR RISK STRATIFICATION OF PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA: A MULTICENTRE STUDY Open
View article: Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8
Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8 Open
View article: MTR-13EVALUATION OF p75 EXPRESSION AND PATTERNS OF RECURRENCE IN PATIENTS WITH MALIGNANT GLIOMAS TREATED WITH BEVACIZUMAB
MTR-13EVALUATION OF p75 EXPRESSION AND PATTERNS OF RECURRENCE IN PATIENTS WITH MALIGNANT GLIOMAS TREATED WITH BEVACIZUMAB Open
BACKGROUND: There is no standard treatment for patients with recurrent malignant gliomas (MGs) and after antiangiogenic therapy, 15% recur in a distant location suggesting the development of VEGF independent invasive mechanisms. We hypothe…
View article: Effect of Atlas Vertebrae Realignment in Subjects with Migraine: An Observational Pilot Study
Effect of Atlas Vertebrae Realignment in Subjects with Migraine: An Observational Pilot Study Open
Introduction . In a migraine case study, headache symptoms significantly decreased with an accompanying increase in intracranial compliance index following atlas vertebrae realignment. This observational pilot study followed eleven neurolo…