James D. Nolin
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View article: Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma
Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma Open
The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant de…
View article: Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung Open
Secreted phospholipase A2 (sPLA2) enzymes release free fatty acids, including arachidonic acid, and generate lysophospholipids from phospholipids, including membrane phospholipids from cells and bacteria and surfactant phospholipids. We ha…
View article: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium
Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium Open
Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and the spike protein activator, TMPRSS2. Here we explore the role…
View article: Airway epithelium–shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling
Airway epithelium–shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling Open
Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of asthma is indirect airway hyperresponsiveness (AHR), and a prominent molecular e…
View article: The Effects of Genotype × Phenotype Interactions on Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells
The Effects of Genotype × Phenotype Interactions on Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells Open
Silver nanoparticles (AgNP) are used in multiple applications but primarily in the manufacturing of antimicrobial products. Previous studies have identified AgNP toxicity in airway epithelial cells, but no in vitro studies to date have use…
View article: Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen
Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen Open
Phospholipase A2 (PLA2) enzymes regulate the formation of eicosanoids and lysophospholipids that contribute to allergic airway inflammation. Secreted PLA2 group X (sPLA2-X) was recently found to be increased in the airways of asthmatics an…
View article: JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers
JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers Open
Background Lung remodeling and pulmonary fibrosis are serious, life‐threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that JNK enzyme functio…
View article: Identification of Epithelial Phospholipase A<sub>2</sub> Receptor 1 as a Potential Target in Asthma
Identification of Epithelial Phospholipase A<sub>2</sub> Receptor 1 as a Potential Target in Asthma Open
Secreted phospholipase A2s (sPLA2s) regulate eicosanoid formation and have been implicated in asthma. Although sPLA2s function as enzymes, some of the sPLA2s bind with high affinity to a C-type lectin receptor, called PLA2R1, which has fun…
View article: Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π
Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π Open
Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by excessive collagen production and fibrogenesis. Apoptosis in lung epithelial cells is critical in IPF pathogenesis, as heightened loss of these cells promo…
View article: Ablation of Glutaredoxin-1 Modulates House Dust Mite–Induced Allergic Airways Disease in Mice
Ablation of Glutaredoxin-1 Modulates House Dust Mite–Induced Allergic Airways Disease in Mice Open
Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein cysteines that impacts structure and function. The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutath…
View article: Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells
Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells Open
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or …
View article: Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein <i>S</i>-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice
Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein <i>S</i>-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice Open
S-glutathionylation has emerged as an oxidant-induced post-translational modification of protein cysteines that affects structure and function. The oxidoreductase glutaredoxin-1 (Glrx1), under physiological conditions, catalyzes deglutathi…
View article: Thiol Redox Chemistry: Role of Protein Cysteine Oxidation and Altered Redox Homeostasis in Allergic Inflammation and Asthma
Thiol Redox Chemistry: Role of Protein Cysteine Oxidation and Altered Redox Homeostasis in Allergic Inflammation and Asthma Open
Asthma is a pulmonary disorder, with an estimated 300 million people affected worldwide. While it is thought that endogenous reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as hydrogen peroxide and nitric oxide, are …
View article: Redox control of allergic airway disease: Impact of glutaredoxin-1 on epithelial driven inflammation and allergen-induced airway remodeling
Redox control of allergic airway disease: Impact of glutaredoxin-1 on epithelial driven inflammation and allergen-induced airway remodeling Open
Asthma is a multi-faceted chronic inflammatory disease accompanied by loss of airway epithelial integrity leading to remodeling of the airways. Perturbations to the lung redox environment, including alterations in glutathione (GSH) content…