Explanipedia

Telehealth for rare disease care, research, and education across the globe: A review of the literature by the IRDiRC telehealth task force Open

Faye H Chen, Adam L. Hartman, Mary Catherine V. Letinturier, Victoria Antoniadou, Gareth Baynam , et al. · 2024

The International Rare Diseases Research Consortium (IRDiRC) Telehealth (TH) Task Force explored the use of TH for improving diagnosis, care, research, and education for rare diseases (RDs). The Task Force reviewed related literature publi…

Predicting Injury and Illness with Machine Learning in Elite Youth Soccer: A Comprehensive Monitoring Approach over 3 Months Open

Nils Haller, Stefan Kranzinger, Christina Kranzinger, Julia C. Blumkaitis, Tilmann Strepp , et al. · 2023

The search for monitoring tools that provide early indication of injury and illness could contribute to better player protection. The aim of the present study was to i) determine the feasibility of and adherence to our monitoring approach,…

Predicting Injury and Illness with Machine Learning in Elite Youth Soccer: A Comprehensive Monitoring Approach over 3 Months Open

Nils Haller, Stefan Kranzinger, Christina Kranzinger, Julia C. Blumkaitis, Tilmann Strepp , et al. · 2023

The search for monitoring tools that provide early indication of injury and illness could contribute to better player protection. The aim of the present study was to i) determine the feasibility of and adherence to our monitoring approach,…

A FRESH LOOK AT THE B1 - X0+ and A1 - X0+ TRANSITIONS IN TUNGSTEN OXIDE, WO: EVIDENCE OF AN AVOIDED CROSSING? Open

L. C. O’Brien, James J. O’Brien · 2023

Suppplementary Information from Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity Open

Yasmin Leshem, James J. O’Brien, Xiufen Liu, Tapan K. Bera, Masaki Terabe , et al. · 2023

Fig S1. Description of DNA constructs Fig S2. Distribution of intra-tumoral injected trypan blue Fig S3. Combination of intra-tumoral immunotoxins with anti-CTLA-4 is well tolerated by mice. Fig S4. Anti-tumor effect of anti-CTLA-4 and LMB…

Data from Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity Open

Yasmin Leshem, James J. O’Brien, Xiufen Liu, Tapan K. Bera, Masaki Terabe , et al. · 2023

Immune checkpoint blockade using antibodies to cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) benefits a limited number of cancer patients. SS1P and LMB-100 are immunotoxins that target mesothelin. We observed delayed responses to SS…

Suppplementary Information from Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity Open

Yasmin Leshem, James J. O’Brien, Xiufen Liu, Tapan K. Bera, Masaki Terabe , et al. · 2023

Fig S1. Description of DNA constructs Fig S2. Distribution of intra-tumoral injected trypan blue Fig S3. Combination of intra-tumoral immunotoxins with anti-CTLA-4 is well tolerated by mice. Fig S4. Anti-tumor effect of anti-CTLA-4 and LMB…

Reducing global health inequalities for a rare disorder: evaluating the international Prader–Willi Syndrome Organisation’s Echo® programme Open

Tanzil Rujeedawa, Nora McNairney, Shelly Cordner, James J. O’Brien, Georgina Loughnan , et al. · 2022

Comprehensive training load monitoring with biomarkers, performance testing, local positioning data, and questionnaires - first results from elite youth soccer Open

Nils Haller, Julia C. Blumkaitis, Tilmann Strepp, Anna Schmuttermair, Lorenz Aglas , et al. · 2022

Load management, i.e., prescribing, monitoring, and adjusting training load, is primarily aimed at preventing injury and maximizing performance. The search for objective monitoring tools to assess the external and internal load of athletes…

Increased DMSP availability during thermal stress influences DMSP-degrading bacteria in coral mucus Open

Stephanie G. Gardner, Matthew R. Nitschke, James J. O’Brien, Cherie A. Motti, Justin R. Seymour , et al. · 2022

Reef-building corals are among the largest producers of dimethylsulfoniopropionate (DMSP), an essential compound in marine biogeochemical cycles. DMSP can be catabolised in coral mucus by a wide diversity of coral-associated bacteria, wher…

The Microbiological Drivers of Temporally Dynamic Dimethylsulfoniopropionate Cycling Processes in Australian Coastal Shelf Waters Open

James J. O’Brien, Erin L. McParland, Anna R. Bramucci, Martin Ostrowski, Nachshon Siboni , et al. · 2022

The organic sulfur compounds dimethylsulfoniopropionate (DMSP) and dimethyl sulfoxide (DMSO) play major roles in the marine microbial food web and have substantial climatic importance as sources and sinks of dimethyl sulfide (DMS). Seasona…

Reducing Global Health Inequalities For A Rare Disorder: Evaluating The International Prader-Willi Syndrome Organisation's Echo® Program Open

Tanzil Rujeedawa, Nora McNairney, Shelly Cordner, James J. O’Brien, Georgina Loughnan , et al. · 2022

Background: people with rare disorders face significant global health inequalities, the challenge is how to raise awareness and develop a nucleus of experts in a country who are then able to provide guidance to others in that country. The …

Biogeographical and seasonal dynamics of the marine Roseobacter community and ecological links to DMSP-producing phytoplankton Open

James J. O’Brien, Erin L. McParland, Anna R. Bramucci, Nachshon Siboni, Martin Ostrowski , et al. · 2022

Ecological interactions between marine bacteria and phytoplankton play a pivotal role in governing the ocean’s major biogeochemical cycles. Among these, members of the marine Roseobacter Group (MRG) can establish mutualistic relationships …

Diatom Biogeography, Temporal Dynamics, and Links to Bacterioplankton across Seven Oceanographic Time-Series Sites Spanning the Australian Continent Open

Nine Le Reun, Anna R. Bramucci, James J. O’Brien, Martin Ostrowski, Mark V. Brown , et al. · 2022

Diatom communities significantly influence ocean primary productivity and carbon cycling, but their spatial and temporal dynamics are highly heterogeneous and are governed by a complex diverse suite of abiotic and biotic factors. We examin…

Addressing underwater noise in Europe: Current state of knowledge and future priorities Open

Frank Thomsen, Sergio C. Mendes, Frédéric Bertucci, Monika Breitzke, Elena Ciappi , et al. · 2021

The Ocean presents a cacophony of sounds originating from natural as well as anthropogenic sources. Marine organisms heavily rely on sound to communicate and understand the world around them, and are therefore potentially impacted by anthr…

OBSERVATION AND SPECTRAL ANALYSIS OF THE A Ω=1 – X Ω=0+ ELECTRONIC TRANSITION OF DIATOMIC PLATINUM SULFIDE, PtS, BY INTRACAVITY LASER ABSORPTION SPECTROSCOPY WITH FOURIER TRANSFORM DETECTION (ILS-FTS) Open

L. C. O’Brien, Wenli Zou, James J. O’Brien, Jack Harms · 2021

Using ILS-FTS, we have recorded the $\\it{A}$ $\\Omega$=1 – $\\it{X}$ $\\Omega$=0$^{+}$ transition of diatomic PtS. Strong bands were observed at 15,520 and 15,910 \\wn, which have been identified as the (0,0) and (1,0) vibrational bands. …

Shifts in dimethylated sulfur concentrations and microbiome composition in the red-tide causing dinoflagellate Alexandrium minutum during a simulated marine heatwave Open

Elisabeth Deschaseaux, James J. O’Brien, Nachshon Siboni, Katherina Petrou, Justin R. Seymour · 2019

The biogenic sulfur compounds dimethyl sulfide (DMS), dimethyl sulfoniopropionate (DMSP) and dimethyl sulfoxide (DMSO) are produced and transformed by diverse populations of marine microorganisms and have substantial physiological, ecologi…

Shifts in organic sulfur cycling and microbiome composition in the red-tide causing dinoflagellate Alexandrium minutum during a simulated marine heat wave Open

Elisabeth Deschaseaux, James J. O’Brien, Nachshon Siboni, Katherina Petrou, Justin R. Seymour · 2018

The biogenic sulfur compounds dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP) and dimethylsulfoxide (DMSO) are produced and transformed by diverse populations of marine microorganisms and have substantial physiological, ecological…

High Temperature Solid-Oxide Electrolyzer 2500 Hour Test Results At The Idaho National Laboratory Open

C. M. Stoots, James J. O’Brien, Stephen Herring, K. G. Condie, L. Moore-McAteer , et al. · 2016

The Idaho National Laboratory (INL) has been developing the concept of using solid oxide fuel cells as electrolyzers for large-scale, high-temperature (efficient), hydrogen production. This program is sponsored by the U.S. Department of En…

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