James R. Occean
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View article: Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging
Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging Open
Loss of regeneration is a key feature of aging organs, often linked to stem cell exhaustion. Skeletal muscle stem cells (MuSCs) undergo age‐related numerical and functional decline, contributing to reduced regenerative potential. Using low…
View article: Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter
Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter Open
View article: Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging Open
DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been imp…
View article: A hyper-quiescent chromatin state formed during aging is reversed by regeneration
A hyper-quiescent chromatin state formed during aging is reversed by regeneration Open
View article: Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging Open
DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been imp…
View article: A hyper-quiescent chromatin state formed during aging is reversed by regeneration
A hyper-quiescent chromatin state formed during aging is reversed by regeneration Open
Summary Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as a model and extending to other quiescent tissues, we find that aging is driven by temporal c…
View article: DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder Open
View article: DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder Open
Background The mechanisms through which exposure to differing trauma types become biologically embedded to shape the risk for subsequent post-traumatic stress disorder (PTSD) is unclear. DNA methylation (5-mC), particularly in stress-relev…
View article: Epigenetic dysregulation in cardiovascular aging and disease
Epigenetic dysregulation in cardiovascular aging and disease Open
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes, racial and ethnic groups. Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modu…