James P. Roach
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View article: Two roles for choice selective inhibition in decision-making circuits
Two roles for choice selective inhibition in decision-making circuits Open
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming choices. Recent work showed that excitatory and inhibitory neurons are equally selective for choice. However, functional consequences of inhibitory ch…
View article: Acetylcholine Mediates Dynamic Switching Between Information Coding Schemes in Neuronal Networks
Acetylcholine Mediates Dynamic Switching Between Information Coding Schemes in Neuronal Networks Open
Rate coding and phase coding are the two major coding modes seen in the brain. For these two modes, network dynamics must either have a wide distribution of frequencies for rate coding, or a narrow one to achieve stability in phase dynamic…
View article: How rhythms of the sleeping brain tune memory and synaptic plasticity
How rhythms of the sleeping brain tune memory and synaptic plasticity Open
Decades of neurobehavioral research has linked sleep-associated rhythms in various brain areas to improvements in cognitive performance. However, it remains unclear what synaptic changes might underlie sleep-dependent declarative memory co…
View article: Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks
Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks Open
Significance Networks of neurons need to reliably encode and replay patterns and sequences of activity. In the brain, sequences of spatially coding neurons are replayed in both the forward and reverse direction in time with respect to thei…
View article: Dataset For "Resonance With Subthreshold Oscillatory Drive Organizes Activity And Optimizes Learning In Neural Networks"
Dataset For "Resonance With Subthreshold Oscillatory Drive Organizes Activity And Optimizes Learning In Neural Networks" Open
This is the experimental dataset for the paper "Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks", doi/10.1073/pnas.1716933115.
View article: Dataset For "Resonance With Subthreshold Oscillatory Drive Organizes Activity And Optimizes Learning In Neural Networks"
Dataset For "Resonance With Subthreshold Oscillatory Drive Organizes Activity And Optimizes Learning In Neural Networks" Open
This is the experimental dataset for the paper "Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks", doi/10.1073/pnas.1716933115.
View article: Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure
Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure Open
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss‐of‐function mutations in ccm3 that result in dilated capillary beds that are susceptible to hemorrhage. Before hemorrhage,…
View article: Dynamic Control of Network Level Information Processing through Cholinergic Modulation
Dynamic Control of Network Level Information Processing through Cholinergic Modulation Open
Acetylcholine (ACh) release is a prominent neurochemical marker of arousal state within the brain. Changes in ACh are associated with changes in neural activity and information processing, though its exact role and the mechanisms through w…
View article: Sub-threshold resonance organizes activity and optimizes learning in neural networks
Sub-threshold resonance organizes activity and optimizes learning in neural networks Open
Network oscillations across and within brain areas are critical for learning and performance in memory tasks. While a large amount of work has focused on the generation of neural oscillations, their effects on neuronal populations’ spiking…
View article: Memory recall and spike-frequency adaptation
Memory recall and spike-frequency adaptation Open
The brain can reproduce memories from partial data; this ability is critical for memory recall. The process of memory recall has been studied using autoassociative networks such as the Hopfield model. This kind of model reliably converges …