James P. White
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View article: The CALERIE™ Genomic Data Resource
The CALERIE™ Genomic Data Resource Open
Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from CALERIE-2™ – the first ever randomized, controlled trial of long-term CR in healthy, non-obese humans – broadly supports a simi…
View article: Spring loaded locator pin assembly
Spring loaded locator pin assembly Open
This invention deals with spring loaded locator pins. Locator pins are sometimes referred to as captured pins. This is a mechanism which locks two items together with the pin that is spring loaded so that it drops into a locator hole on th…
View article: Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1 Open
The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinc…
View article: Author response: Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
Author response: Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1 Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstrac…
View article: Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis and muscle hypertrophy by Isthmin-1
Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis and muscle hypertrophy by Isthmin-1 Open
The secreted protein Isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinc…
View article: Biological age is increased by stress and restored upon recovery
Biological age is increased by stress and restored upon recovery Open
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal…
View article: The role of Meteorin‐like in skeletal development and bone fracture healing
The role of Meteorin‐like in skeletal development and bone fracture healing Open
Meteorin‐like protein (Metrnl), homologous to the initially identified neurotrophic factor Meteorin, is a secreted, multifunctional protein. Here we used mouse models to investigate Metrnl's role in skeletal development and bone fracture h…
View article: Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension
Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension Open
Heterochronic parabiosis is a powerful rejuvenation model in aging research. Due to limitations in the duration of blood sharing and/or physical attachment, it is currently unclear if parabiosis retards the molecular signatures of aging or…
View article: 836 Murine fecal microbiota transfer models colonize human microbes selectively and reveal transcriptional pathways associated with response to neoadjuvant checkpoint inhibitors
836 Murine fecal microbiota transfer models colonize human microbes selectively and reveal transcriptional pathways associated with response to neoadjuvant checkpoint inhibitors Open
Background Human gut microbial species found to associate with clinical responses to immune checkpoint inhibitors (ICIs) are often tested in murine models using fecal microbiota transfer (FMT), wherein tumor responses in recipient mice may…
View article: Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis
Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis Open
West Nile virus (WNV) is an emerging pathogen that causes disease syndromes ranging from a mild flu‐like illness to encephalitis. While the incidence of WNV infection is fairly uniform across age groups, the risk of lethal encephalitis inc…
View article: The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells
The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells Open
Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis. During periods of metabolic stress, the subcellular …
View article: Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand
Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand Open
Skeletal muscle protein synthesis is a highly complex process, influenced by nutritional status, mechanical stimuli, repair programs, hormones, and growth factors. The molecular aspects of protein synthesis are centered around the mTORC1 c…
View article: Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis
Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis Open
RA, even when controlled, is associated with skeletal muscle weakness and greater risk of cardiovascular disease (CVD). Using exercise as a therapeutic against, the progression of RA is often avoided due to fear of worsening RA pathology. …
View article: Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection
Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection Open
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection. However, the role of astrocytes in inna…
View article: AGS and NIA Bench‐to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders
AGS and NIA Bench‐to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders Open
This report summarizes the presentations and recommendations of the eleventh annual American Geriatrics Society and National Institute on Aging research conference, “Osteoporosis and Soft Tissue (Muscle/Fat) Disorders,” on March 11‐12, 201…
View article: Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation
Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation Open
Although both exercise and thyroid hormone (TH) status can cause cellular and metabolic changes in skeletal muscle, the impact of TH status on exercise-associated changes is not well understood. Here, we examined the effects of TH status o…
View article: Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques
Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques Open
Background Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the …
View article: Lowering circulating apolipoprotein E levels improves aged bone fracture healing
Lowering circulating apolipoprotein E levels improves aged bone fracture healing Open
Age is a well-established risk factor for impaired bone fracture healing. Here, we identify a role for apolipoprotein E (ApoE) in age-associated impairment of bone fracture healing and osteoblast differentiation, and we investigate the mec…
View article: Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy Open
Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend li…
View article: Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration Open
Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes …