James Phung
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View article: Clonal Hematopoiesis and Cardiovascular Disease and Bleeding Risk and the Effectiveness of Aspirin
Clonal Hematopoiesis and Cardiovascular Disease and Bleeding Risk and the Effectiveness of Aspirin Open
Importance Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with increased risk of cardiovascular disease (CVD) events and mortality. However, there are no approved therapies for preventing or treating CHIP. Objec…
View article: Low-Dose Aspirin for Individualized Cancer Prevention in Older Adults
Low-Dose Aspirin for Individualized Cancer Prevention in Older Adults Open
Importance The role of low-dose aspirin (LDA) in cancer prevention among older adults is unclear. Identifying individuals likely to experience benefit or harm is crucial for guiding personalized prevention strategies. Objective To identify…
View article: The impact of pre-analytical factors on plasma biomarkers for Alzheimer's disease: The ASPREE Healthy Ageing Biobank
The impact of pre-analytical factors on plasma biomarkers for Alzheimer's disease: The ASPREE Healthy Ageing Biobank Open
Following standard operating procedures, AD biomarkers can be measured in plasma from biobanks stored for up to 13 years, with minimal impact from long-term storage or other pre-analytical factors.
View article: Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration
Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration Open
Importance Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in old age. There is no proven intervention to prevent AMD and, apart from lifestyle, nutritional, and supplement advice, there is no interv…
View article: The ASPREE Healthy Ageing Biobank: Methodology and participant characteristics
The ASPREE Healthy Ageing Biobank: Methodology and participant characteristics Open
ASPirin in Reducing Events in the Elderly (ASPREE), a placebo-controlled prevention trial of low dose aspirin, provided the opportunity to establish a biospecimen biobank from initially healthy persons aged 70+ years for future research. T…
View article: DNA Methylation Analysis of Candidate Genes Associated with Dementia in Peripheral Blood
DNA Methylation Analysis of Candidate Genes Associated with Dementia in Peripheral Blood Open
Aim: To investigate whether genes implicated in dementia pathogenesis are differently methylated in peripheral blood. Materials & methods: Participants included 160 cognitively healthy individuals aged 70+ years: 73 who were subsequently d…
View article: Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms
Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms Open
Discernible blood DNAm signatures are in dementia cases before the appearance of overt clinical symptoms. Blood-based methylation may serve as a potential biomarker of dementia, but further investigation is needed to determine their true c…
View article: Resilience to dominant genetic disease in the healthy elderly
Resilience to dominant genetic disease in the healthy elderly Open
Here we describe genomic screening of the healthy elderly to identify those resilient to adult-onset genetic disease, despite being at exceptionally high genetic risk. We sequenced 13,131 individuals aged 70 or older (mean age 75 years) fr…
Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study Open
Context There is a lack of understanding of what is normal in terms of sex steroid levels in older women. Objective To determine whether sex steroid levels vary with age in and establish reference ranges for women >70 years of age. Design …
View article: Development and validation of a deep‐learning algorithm for the detection of neovascular age‐related macular degeneration from colour fundus photographs
Development and validation of a deep‐learning algorithm for the detection of neovascular age‐related macular degeneration from colour fundus photographs Open
Importance Detection of early onset neovascular age‐related macular degeneration (AMD) is critical to protecting vision. Background To describe the development and validation of a deep‐learning algorithm (DLA) for the detection of neovascu…