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View article: Analytical Dual Flip Angle R1 Calculation Outside the Small‐Angle Regime
Analytical Dual Flip Angle R1 Calculation Outside the Small‐Angle Regime Open
Purpose To evaluate a new analytical estimator for R1 and apparent proton density () from short‐TR dual flip angle data which does not rely on the small flip angle approximation and can thus be applied to a broader range of data, especiall…
View article: A unified <scp>3D</scp> reconstruction of microscopy and <scp>MRI</scp> in a brain showing Alzheimer's disease‐related neuropathology
A unified <span>3D</span> reconstruction of microscopy and <span>MRI</span> in a brain showing Alzheimer's disease‐related neuropathology Open
To bridge between detailed post‐mortem neuropathological assessments and Magnetic Resonance Imaging (MRI), we have created and share a three‐dimensional (3D) account of an entire human brain with an intermediate Alzheimer's disease neuropa…
View article: Ultra-high-field fMRI reveals layer-specific responses in the human spinal cord
Ultra-high-field fMRI reveals layer-specific responses in the human spinal cord Open
Developments in functional magnetic resonance imaging (fMRI) at ultra-high field (UHF) now allow for insights into human brain function at mesoscopic scale. However, similar progress has not been achieved for the human spinal cord, despite…
View article: High‐density MRI coil arrays with integrated field monitoring systems for human connectome mapping
High‐density MRI coil arrays with integrated field monitoring systems for human connectome mapping Open
Purpose To develop and test two high‐density MRI coil arrays with integrated field monitoring systems for enhanced diffusion imaging with strong diffusion‐sensitizing gradients. Methods Two multichannel head coils were constructed for firs…
View article: Blood Flow Velocity Analysis in Cerebral Perforating Arteries on 7T 2D Phase Contrast MRI with an Open-Source Software Tool (SELMA)
Blood Flow Velocity Analysis in Cerebral Perforating Arteries on 7T 2D Phase Contrast MRI with an Open-Source Software Tool (SELMA) Open
View article: Short-term BCI intervention enhances functional brain connectivity associated with motor performance in chronic stroke
Short-term BCI intervention enhances functional brain connectivity associated with motor performance in chronic stroke Open
Our findings suggest that BCI training can enhance brain connectivity, underlying the observed improvements in motor function. They provide a basis for developing novel rehabilitation approaches using non-invasive brain stimulation for tar…
View article: Short association fibres form topographic sheets in the human V1–V2 processing stream
Short association fibres form topographic sheets in the human V1–V2 processing stream Open
Despite the importance of short association fibres (SAF) for human brain function, their structures remain understudied. It is not known how SAF are organised across the brain, and how consistent their geometries and locations are across i…
View article: Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology
Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology Open
Chimpanzee brain maturation provides an invaluable framework for understanding the evolution of the human brain. We performed ultra-high resolution quantitative magnetic resonance imaging (qMRI) with histological validation on post mortem …
View article: Blood flow velocity analysis in cerebral perforating arteries on 7T 2D phase contrast MRI with an open-source software tool (SELMA)
Blood flow velocity analysis in cerebral perforating arteries on 7T 2D phase contrast MRI with an open-source software tool (SELMA) Open
View article: Mapping short association fibre connectivity up to V3 in the human brain <i>in vivo</i>
Mapping short association fibre connectivity up to V3 in the human brain <i>in vivo</i> Open
Short association fibres (SAF) are the most abundant fibre pathways in the human white matter. Until recently, SAF could not be mapped comprehensively in vivo because diffusion weighted magnetic resonance imaging with sufficiently high spa…
View article: <i>In Situ</i> Magnetometry of Iron in Human Dopaminergic Neurons Using Superresolution MRI and Ion-Beam Microscopy
<i>In Situ</i> Magnetometry of Iron in Human Dopaminergic Neurons Using Superresolution MRI and Ion-Beam Microscopy Open
Paramagnetic transition metals play a crucial role as cofactors in various cellular catalytic processes. However, their high concentrations in reactive oxidation states can induce oxidative stress, resulting in cell dysfunction or death. H…
View article: Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring
Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring Open
Purpose To compare MR axon radius estimation in human white matter using a multiband spiral sequence combined with field monitoring to the current state‐of‐the‐art echo‐planar imaging (EPI)‐based approach. Methods A custom multiband spiral…
View article: Connectivity at fine scale: mapping structural connective fields by tractography of short association fibres<i>in vivo</i>
Connectivity at fine scale: mapping structural connective fields by tractography of short association fibres<i>in vivo</i> Open
Summary The extraordinary number of short association fibres (SAF) connecting neighbouring cortical areas is a prominent feature of the large gyrified human brain. The contribution of SAF to the human connectome is largely unknown because …
View article: Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution
Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution Open
To decipher the evolution of the hominoid brain and its functions, it is essential to conduct comparative studies in primates, including our closest living relatives. However, strong ethical concerns preclude in vivo neuroimaging of great …
View article: Ultra‐high‐resolution quantitative MRI at the grey/white interface in Alzheimer’s disease and posterior cortical atrophy
Ultra‐high‐resolution quantitative MRI at the grey/white interface in Alzheimer’s disease and posterior cortical atrophy Open
Background Cortical grey matter (CGM) and superficial white matter (SWM) undergo pathological changes, but standard MRI spatial resolutions make interpreting disease‐related effects at their interface challenging. We present findings from …
View article: Fiber-orientation independent component of R2* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm
Fiber-orientation independent component of R2* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm Open
The effective transverse relaxation rate (R 2 *) is sensitive to the microstructure of the human brain like the g-ratio which characterises the relative myelination of axons. However, the fibre-orientation dependence of R 2 * degrades its …
View article: High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex
High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex Open
The characterization of cortical myelination is essential for the study of structure-function relationships in the human brain. However, knowledge about cortical myelination is largely based on post-mortem histology, which generally render…
View article: Sourcing high tissue quality brains from deceased wild primates with known socio‐ecology
Sourcing high tissue quality brains from deceased wild primates with known socio‐ecology Open
The selection pressures that drove dramatic encephalisation processes through the mammal lineage remain elusive, as does knowledge of brain structure reorganisation through this process. In particular, considerable structural brain changes…
View article: Author response: High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex
Author response: High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Appendix 6 Appendix 7 Data availability References Decision letter Author re…
View article: B1+$$ {B}_1^{+} $$‐correction of magnetization transfer saturation maps optimized for 7T postmortem MRI of the brain
B1+$$ {B}_1^{+} $$‐correction of magnetization transfer saturation maps optimized for 7T postmortem MRI of the brain Open
Purpose Magnetization transfer saturation () is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased ‐inhomogeneity at T and significantly larger saturation pulse flip angles which are often us…
View article: Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis
Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis Open
Quantitative magnetic resonance imaging (qMRI) allows extraction of reproducible and robust parameter maps. However, the connection to underlying biological substrates remains murky, especially in the complex, densely packed cortex. We inv…
View article: Swallow Tail Sign: Revisited
Swallow Tail Sign: Revisited Open
The loss of the radiologic swallow tail sign on MRI scans of the substantia nigra is a promising diagnostic marker of Parkinson disease (1), although its anatom-ic underpinning is unclear. An early influential study showed that the hyperin…
View article: Error quantification in multi-parameter mapping facilitates robust estimation and enhanced group level sensitivity
Error quantification in multi-parameter mapping facilitates robust estimation and enhanced group level sensitivity Open
View article: <i>B</i><sub>1</sub><sup>+</sup>-correction of MT saturation maps optimized for 7T<i>postmortem</i>MRI of the brain
<i>B</i><sub>1</sub><sup>+</sup>-correction of MT saturation maps optimized for 7T<i>postmortem</i>MRI of the brain Open
Purpose Magnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased -inhomogeneity at ≥ 7T and significantly larger saturation pulse flip angles which are …
View article: High resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex
High resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex Open
The characterization of cortical myelination is essential for the study of structure-function relationships in the human brain. However, knowledge about cortical myelination is largely based on post mortem histology, which generally render…
View article: A unified 3D map of microscopic architecture and MRI of the human brain
A unified 3D map of microscopic architecture and MRI of the human brain Open
We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens.…
View article: Combining navigator and optical prospective motion correction for <scp>high‐quality</scp> 500 μm resolution quantitative <scp>multi‐parameter</scp> mapping at <scp>7T</scp>
Combining navigator and optical prospective motion correction for <span>high‐quality</span> 500 μm resolution quantitative <span>multi‐parameter</span> mapping at <span>7T</span> Open
Purpose High‐resolution quantitative multi‐parameter mapping shows promise for non‐invasively characterizing human brain microstructure but is limited by physiological artifacts. We implemented corrections for rigid head movement and respi…
View article: Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis
Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis Open
Quantitative MRI (qMRI) allows extraction of reproducible and robust parameter maps. However, the connection to underlying biological substrates remains murky, especially in the complex, densely packed cortex. We investigated associations …
View article: Deciphering the fibre-orientation independent component of R<sub>2</sub>* (R<sub>2,iso</sub>*) in the human brain with a single multi-echo gradient-recalled-echo measurement under varying microstructural conditions
Deciphering the fibre-orientation independent component of R<sub>2</sub>* (R<sub>2,iso</sub>*) in the human brain with a single multi-echo gradient-recalled-echo measurement under varying microstructural conditions Open
The effective transverse relaxation rate (R 2 *) is sensitive to the microstructure of the human brain, e.g. the g-ratio characterising the relative myelination of axons. However, R 2 * depends on the orientation of the fibres relative to …
View article: Error quantification in multi-parameter mapping facilitates robust estimation and enhanced group level sensitivity
Error quantification in multi-parameter mapping facilitates robust estimation and enhanced group level sensitivity Open
Multi-Parameter Mapping (MPM) is a comprehensive quantitative neuroimaging protocol that enables estimation of four physical parameters (longitudinal and effective transverse relaxation rates R 1 and , proton density PD , and magnetization…