Andrew H. Baker
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View article: The Medical Research Council/British Heart Foundation Centre of Research Excellence in Advanced Cardiac Therapies (REACT)
The Medical Research Council/British Heart Foundation Centre of Research Excellence in Advanced Cardiac Therapies (REACT) Open
View article: Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure
Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure Open
Coronary artery bypass graft (CABG) surgery remains the gold standard of care to prevent myocardial ischemia in patients with advanced atherosclerosis; however, poor long-term graft patency remains a considerable and long-standing problem.…
View article: The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination
The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination Open
Recent studies have described disease-associated expression patterns of long non-coding RNAs (lncRNAs) associated with neurodevelopment and neurodegeneration, highlighting their potential as regulators of function and therefore potential t…
View article: Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation
Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation Open
View article: The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes
The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes Open
Aims Vascular calcification is the abnormal deposition of calcium phosphates within blood vessels. This condition is significantly associated with the development of cardiovascular disease, yet the underlying mechanisms remain largely unkn…
View article: Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics
Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics Open
In the past decade, there has been substantive progress in gene therapy across disease indications. However, despite multiple gene therapies being approved for clinical use, none have a cardiovascular indication. Several reasons for this h…
View article: Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease
Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease Open
The cardiopulmonary vasculature and its associated endothelial cells (ECs) play an essential role in sustaining life by ensuring the delivery of oxygen and nutrients. Beyond these foundational functions, ECs serve as key regulators of immu…
View article: Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy
Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy Open
Aims The highly conserved long non-coding RNA (lncRNA) MIR505HG has been primarily recognized as a precursor for microRNAs (miR)-424 and miR-503. However, studies have since demonstrated that MIR503HG has distinct functions from its associ…
View article: ERC-funded Advanced Grant: creating molecular polypills
ERC-funded Advanced Grant: creating molecular polypills Open
View article: Targeted approach for next-generation coronary stents
Targeted approach for next-generation coronary stents Open
View article: Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction
Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction Open
Adiponectin is the most abundant hormone in the circulation. Plasma adiponectin decreases in obesity but increases in leanness, including during caloric restriction (CR) in animals and humans. In obesity, adiponectin deficiency promotes ca…
View article: Implications of a new clinical classification of acute myocardial infarction
Implications of a new clinical classification of acute myocardial infarction Open
Aims The diagnostic criteria for Type 2 myocardial infarction identify a heterogeneous group of patients with variable outcomes and no clear treatment implications. We aimed to determine the implications of a new clinical classification fo…
View article: Myocardial Fibroblast Activation After Acute Myocardial Infarction
Myocardial Fibroblast Activation After Acute Myocardial Infarction Open
Myocardial fibroblast activation peaks within a week of acute myocardial infarction and extends beyond the infarct region. It declines slowly with time, persists for years, and is associated with subsequent left ventricular remodeling. (PR…
View article: Functional screening identifies miRNAs with a novel function inhibiting vascular smooth muscle cell proliferation
Functional screening identifies miRNAs with a novel function inhibiting vascular smooth muscle cell proliferation Open
View article: Prediction of COVID‐19 severity using machine learning
Prediction of COVID‐19 severity using machine learning Open
View article: Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis
Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis Open
Aims Vein grafts are used for many indications, including bypass graft surgery and arteriovenous fistula (AVF) formation. However, patency following vein grafting or AVF formation is suboptimal for various reasons, including thrombosis, ne…
View article: Non‐coding RNAs to treat vascular smooth muscle cell dysfunction
Non‐coding RNAs to treat vascular smooth muscle cell dysfunction Open
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non‐coding RNAs (ncRNAs…
View article: Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality Open
View article: P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats
P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats Open
View article: Functional screening identifies novel miRNAs inhibiting Vascular Smooth Muscle Cell proliferation
Functional screening identifies novel miRNAs inhibiting Vascular Smooth Muscle Cell proliferation Open
Proliferation of vascular smooth muscle cells (vSMCs) following injury is a crucial contributor to pathological vascular remodelling. MicroRNAs (miRNAs) are powerful gene regulators and attractive therapeutic agents. Here, we aim to system…
View article: Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression
Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression Open
View article: The dual effects of miR-222 in cardiac hypertrophy: bridging pathological and physiological paradigms
The dual effects of miR-222 in cardiac hypertrophy: bridging pathological and physiological paradigms Open
View article: Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease
Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease Open
Endothelial cells (ECs) line the luminal surface of blood vessels and play a major role in vascular (patho)-physiology by acting as a barrier, sensing circulating factors and intrinsic/extrinsic signals. ECs have the capacity to undergo en…
View article: COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium
COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium Open
During COVID-19, the pMV undergoes significant remodelling, which is evident based on the functional, phenotypic, and transcriptional changes seen following exposure to COVID-19 plasma. The observed morphological variation may be responsib…
View article: Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490
Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490 Open
Background Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes c…
View article: Epigenetic control of vascular endothelial function revealed by multi-omics
Epigenetic control of vascular endothelial function revealed by multi-omics Open
View article: Extracellular vesicles from differentiated stem cells contain novel proangiogenic miRNAs and induce angiogenic responses at low doses
Extracellular vesicles from differentiated stem cells contain novel proangiogenic miRNAs and induce angiogenic responses at low doses Open
View article: Non-coding RNAs to treat vascular smooth cell dysfunction
Non-coding RNAs to treat vascular smooth cell dysfunction Open
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis, and vein graft failure. Recent advances have unveiled a fascinating breadth of non-coding RNAs (ncR…
View article: Colchicine promotes atherosclerotic plaque stability independently of inflammation
Colchicine promotes atherosclerotic plaque stability independently of inflammation Open
Atherosclerosis is a chronic inflammatory disease which is driven in part by the aberrant trans -differentiation of vascular smooth muscle cells (SMCs). No therapeutic drug has been shown to reverse detrimental SMC-derived cell phenotypes …
View article: Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490
Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490 Open
Background Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Non-invasive imaging using a radiotracer targeting these processes …