James R. Bateman
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View article: Plasma biomarkers in neuropsychiatric syndromes: A narrative review
Plasma biomarkers in neuropsychiatric syndromes: A narrative review Open
Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding biomarkers. Further, emerging evidence describes the utility of systematic a…
View article: The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias
The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias Open
INTRODUCTION The Neighborhoods Study (TNS) is a novel investigation of adverse social exposome and brain health leveraging 22 Alzheimer's Disease Research Centers (ADRCs). TNS aims to understand if the adverse social exposures increase Alz…
View article: Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias
Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias Open
INTRODUCTION Relationships between place‐based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers are emerging. METHODS Linear regressions examined associations of area deprivation index (ADI), so…
View article: The Relationship of Alzheimer's Disease and Related Dementias Blood‐Based Biomarkers and Informant‐Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia
The Relationship of Alzheimer's Disease and Related Dementias Blood‐Based Biomarkers and Informant‐Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia Open
Objectives In a sample of community‐dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood‐based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e…
View article: Adverse childhood experiences influence markers of neurodegeneration risk in older adults
Adverse childhood experiences influence markers of neurodegeneration risk in older adults Open
INTRODUCTION Adverse childhood experiences (ACEs) disrupt brain development and increase vulnerability to Alzheimer's disease and related dementias (ADRD). We explored how ACEs impact neuroimaging, plasma biomarkers, and cognition in older…
View article: Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies
Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies Open
INTRODUCTION Current evidence supports the use of cholinesterase inhibitors (ChEIs) as the first‐line symptomatic treatment for improving cognition in dementia with Lewy bodies (DLB). Little is known about current prescribing patterns of C…
View article: Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort
Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort Open
INTRODUCTION Studies suggest excellent performance of plasma phosphorylated tau 217 (p‐tau217) for detecting amyloid pathology, though studies in more representative populations are needed to validate previously determined cutpoints. METHO…
View article: Evaluation of In-person versus Remote Cognitive Assessment in Cognitively Unimpaired Older Adults via Regression-Based Change Analysis
Evaluation of In-person versus Remote Cognitive Assessment in Cognitively Unimpaired Older Adults via Regression-Based Change Analysis Open
Objective Compare the changes in neuropsychological test scores between remote and in-person follow-up assessment over a 1-year period using standardized regression–based (SRB) change indices. Method Participants were from the Wake Forest …
View article: Chronic stress, social support, and Alzheimer's blood‐based biomarkers in the HABS‐HD study
Chronic stress, social support, and Alzheimer's blood‐based biomarkers in the HABS‐HD study Open
INTRODUCTION High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear. METHODS We included 2117 older adults (mean age 65.5 years) enrol…
View article: Evaluation of plasma p-tau217 for detecting amyloid pathology in a diverse and heterogeneous community-based cohort
Evaluation of plasma p-tau217 for detecting amyloid pathology in a diverse and heterogeneous community-based cohort Open
INTRODUCTION: Studies suggest excellent performance of plasma p-tau217 for detecting amyloid pathology, though studies in more diverse populations are needed to validate previously determined cutpoints. METHODS: Plasma p-tau217 utility for…
View article: Vascular‐based risk scores for the prediction of Alzheimer’s disease pathology biomarkers and cognitive status in older adults at‐risk for dementia: Exploratory analysis of sex and ethno‐racial differences
Vascular‐based risk scores for the prediction of Alzheimer’s disease pathology biomarkers and cognitive status in older adults at‐risk for dementia: Exploratory analysis of sex and ethno‐racial differences Open
Background Vascular‐based dementia risk scores (VDRS) which reliably predict risk of Alzheimer’s disease and related dementias (ADRDs), may be useful to identify at‐risk individuals for secondary prevention trials. Dementia risk scores hav…
View article: Differential whole‐brain patterns of cardiometabolic risk and blood biomarker using multi‐modal neuroimaging and explainable deep learning
Differential whole‐brain patterns of cardiometabolic risk and blood biomarker using multi‐modal neuroimaging and explainable deep learning Open
Background Cardiometabolic disorders are emerging risk factors for Alzheimer's disease (AD) and AD‐related dementia (ADRD). There is currently insufficient understanding of how different cardiometabolic profiles and blood biomarkers impact…
View article: Over‐Representation of Extremely Wealthy Neighborhood Social Exposomes for Brain Donors within Alzheimer’s Disease Research Center Brain Banks assessed by the Neighborhoods Study
Over‐Representation of Extremely Wealthy Neighborhood Social Exposomes for Brain Donors within Alzheimer’s Disease Research Center Brain Banks assessed by the Neighborhoods Study Open
Background Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80‐100 or ‘high ADI’) is linked to structural inequities and increased risk of Alzheimer’s disease neuropathology. Twenty percent of the US population res…
View article: Differential whole‐brain patterns of cardiometabolic risk and blood biomarker using multi‐modal neuroimaging and explainable deep learning
Differential whole‐brain patterns of cardiometabolic risk and blood biomarker using multi‐modal neuroimaging and explainable deep learning Open
Background Cardiometabolic disorders are emerging risk factors for Alzheimer's disease (AD) and AD‐related dementia (ADRD). There is currently insufficient understanding of how different cardiometabolic profiles and blood biomarkers impact…
View article: Screening for the Spectrum of Cognitive Impairment in Primary Care: Development of a Machine Learning Informed, Workflow‐Friendly Care Model
Screening for the Spectrum of Cognitive Impairment in Primary Care: Development of a Machine Learning Informed, Workflow‐Friendly Care Model Open
Introduction Over 9 million Americans are projected to have dementia by 2030, and adults with mild cognitive impairment (MCI), a potential pre‐cursor to dementia, will also rise. With recent and emerging clinical trial evidence for interve…
View article: Characterizing dementia risk in individuals with mild cognitive impairment using manifold learning, blood biomarkers, cognitive and imaging data
Characterizing dementia risk in individuals with mild cognitive impairment using manifold learning, blood biomarkers, cognitive and imaging data Open
Background Uniform manifold approximation and projection (UMAP) is a technique for dimension reduction and visualization of high‐dimensional (HD) data. Here, we apply UMAP to represent in two dimensions, data from members of the Wake Fores…
View article: The Relationship of Neuropsychiatric Symptoms and ADRD Pathologies
The Relationship of Neuropsychiatric Symptoms and ADRD Pathologies Open
Background Neuropsychiatric symptoms (NPS) in the Alzheimer’s Disease (AD) clinical spectrum are common, yet the pathological underpinnings are unclear. Prior research has been inconsistent, attributed in part to concomitant co‐pathologies…
View article: The Relationship of Neuropsychiatric Symptoms and ADRD Pathologies
The Relationship of Neuropsychiatric Symptoms and ADRD Pathologies Open
Background Neuropsychiatric symptoms (NPS) in the Alzheimer’s Disease (AD) clinical spectrum are common, yet the pathological underpinnings are unclear. Prior research has been inconsistent, attributed in part to concomitant co‐pathologies…
View article: Heart rate variability during routine cognitive testing: preliminary analyses of time and frequency domain metrics
Heart rate variability during routine cognitive testing: preliminary analyses of time and frequency domain metrics Open
Background Early autonomic function changes in Alzheimer’s disease (AD) may represent a biomarker for early affective changes in prodromal disease. We report preliminary differences in metrics of heart rate variability (HRV) before and dur…
View article: Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community‐dwelling cohort
Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community‐dwelling cohort Open
INTRODUCTION Neighborhood disadvantage may be an important determinant of cardiometabolic health and cognitive aging. However, less is known about relationships among individuals with mild cognitive impairment (MCI). METHODS The objective …
View article: Social genomics, cognition, and well‐being during the COVID‐19 pandemic
Social genomics, cognition, and well‐being during the COVID‐19 pandemic Open
INTRODUCTION Adverse psychosocial exposure is associated with increased pro‐inflammatory gene expression and reduced type‐1 interferon gene expression known as the conserved transcriptional response to adversity (CTRA). CTRA is not well‐st…
View article: The protean presentations of XK disease (McLeod syndrome): a case series with new observations and updates on previously reported families
The protean presentations of XK disease (McLeod syndrome): a case series with new observations and updates on previously reported families Open
XK disease is a very rare, multi-system disease, which can present with a wide spectrum of symptoms. This disorder can also be identified pre-symptomatically with the incidental detection of serological abnormalities when typing erythrocyt…
View article: A neural network for religious fundamentalism derived from patients with brain lesions
A neural network for religious fundamentalism derived from patients with brain lesions Open
Religious fundamentalism, characterized by rigid adherence to a set of beliefs putatively revealing inerrant truths, is ubiquitous across cultures and has a global impact on society. Understanding the psychological and neurobiological proc…
View article: Depressive Symptoms Affect Cognitive Functioning from Middle to Late Adulthood: Ethnoracial Minorities Experience Greater Repercussions
Depressive Symptoms Affect Cognitive Functioning from Middle to Late Adulthood: Ethnoracial Minorities Experience Greater Repercussions Open
View article: Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities in a community‐dwelling cohort
Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities in a community‐dwelling cohort Open
INTRODUCTION We evaluated associations between plasma and neuroimaging‐derived biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities. METHODS We examined plasma biomarkers (neurofilament lig…
View article: Examining a Preclinical Alzheimer’s Cognitive Composite for Telehealth Administration for Reliability Between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers
Examining a Preclinical Alzheimer’s Cognitive Composite for Telehealth Administration for Reliability Between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers Open
Background: The preclinical Alzheimer’s cognitive composite (PACC) was developed for in-person administration to capture subtle cognitive decline. At the outset of the COVID-19 pandemic, cognitive testing was increasingly performed remotel…
View article: Peripheral Blood Cells From Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function
Peripheral Blood Cells From Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function Open
Blood-based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use 2 complementary r…
View article: Differential diagnosis of frontotemporal dementia subtypes with explainable deep learning on structural MRI
Differential diagnosis of frontotemporal dementia subtypes with explainable deep learning on structural MRI Open
Background Frontotemporal dementia (FTD) represents a collection of neurobehavioral and neurocognitive syndromes that are associated with a significant degree of clinical, pathological, and genetic heterogeneity. Such heterogeneity hinders…
View article: Biopsychosocial contexts influence adult cognitive function concurrently and longitudinally
Biopsychosocial contexts influence adult cognitive function concurrently and longitudinally Open
The relationships among physiological risk factors, social protective factors and cognitive functioning appear to be temporally different during mid-adulthood. Given many of the whole sample findings were not replicated within the racial m…
View article: Feasibility of Remote Administration of the Uniform Data Set-Version 3 for Assessment of Older Adults With Mild Cognitive Impairment and Alzheimer’s Disease
Feasibility of Remote Administration of the Uniform Data Set-Version 3 for Assessment of Older Adults With Mild Cognitive Impairment and Alzheimer’s Disease Open
Objective Assess the feasibility and concurrent validity of a modified Uniform Data Set version 3 (UDSv3) for remote administration for individuals with normal cognition (NC), mild cognitive impairment (MCI), and early dementia. Method Par…