Explanipedia

Videoconferencing for Large Animal Trauma Experiments During COVID-19: A Cross-Continent Experience Open

Nabil Ali-Mohamad, Massimo F. Cau, James R. Baylis, Hugh A. Semple, Christian J. Kastrup , et al. · 2022

Introduction COVID-19 shutdowns in many research facilities across North America impacted preclinical trauma-related research and development. Shutdown limited the speed and resources available for large animal experiments necessary for ad…

Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study Open

Nabil Ali-Mohamad, Massimo F. Cau, James R. Baylis, Veronika Zenova, Hugh A. Semple , et al. · 2021

Background and study aims Hemostatic powders have emerged recently to treat upper gastrointestinal bleeding (UGIB). Previously, we developed a novel self-propelling thrombin powder (SPTP) that effectively manages external pulsatile arteria…

The adhesion of clots in wounds contributes to hemostasis and can be enhanced by coagulation factor XIII Open

Karen Y. T. Chan, Alyssa S. M. Yong, Xu Wang, Kristyn M. Ringgold, Alexander E. St. John , et al. · 2020

Bleeding is increased in amyloid precursor protein knockout mouse Open

Nima Mazinani, Amy W. Strilchuk, James R. Baylis, Woosuk S. Hur, Wilfred A. Jefferies , et al. · 2020

Tu1478 NOVEL HEMOSTATIC POWDER STOPS BLEEDING IN A LIVE PROCINE MODEL OF UPPER GASTROINTESTINAL BLEEDING Open

Fergal Donnellan, Nabil Ali-Mohamad, Massimo F. Cau, James R. Baylis, Veronika Zenova , et al. · 2020

LO13: Development of a national, standardized simulation case template Open

James R. Baylis, C. Heyd, Brent Thoma, Adam Hall, T. Chaplin , et al. · 2020

Innovation Concept: A major barrier to the development of a national simulation case repository and multi-site simulation research is the lack of a standardized national case template. This issue was recently identified as a priority resea…

Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self‐propelling particles Open

James R. Baylis, Michael M. Lee, Alexander E. St. John, Xu Wang, Eric Simonson , et al. · 2019

Improving the efficacy of hemostatic agents by increasing their transport into wounds Open

James R. Baylis · 2019

Uncontrollable hemorrhage remains a leading cause of mortality in many situations, including during surgery and following trauma. Many hemostatic interventions have been developed, but mortality and morbidity remain high because they are i…

P014: Palliative and end of life care education in Canadian emergency medicine residency programs: a national cross-sectional survey Open

James R. Baylis, Devin Harris, C. Chen, D.K. Ting, Anthony Kwan , et al. · 2017

Table of contents Open

Kathleen Yaremchuk, Vigen Darian, Amy Williams, Joshua M. Levy, Timothy L. Smith , et al. · 2017

Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma Open

Ju Hun Yeon, Nima Mazinani, Travis S. Schlappi, Karen Y. T. Chan, James R. Baylis , et al. · 2017

Short-chain polyphosphate (polyP) is released from platelets upon platelet activation, but it is not clear if it contributes to thrombosis. PolyP has increased propensity to clot blood with increased polymer length and when localized onto …

Thrombolysis by chemically modified coagulation factor Xa Open

Edward L.G. Pryzdial, Scott C. Meixner, Kimberley Talbot, Louise J. Eltringham‐Smith, James R. Baylis , et al. · 2016

Halting hemorrhage with self-propelling particles and local drug delivery Open

James R. Baylis, Karen Y. T. Chan, Christian J. Kastrup · 2016

Self-propelled particles that transport cargo through flowing blood and halt hemorrhage Open

James R. Baylis, Ju Hun Yeon, Max H. Thomson, Amir Kazerooni, Xu Wang , et al. · 2015

Simple, water-reactive particles can carry enzymes upstream through aqueous solutions and into wounds to halt severe bleeding.

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