James R. Larkin
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View article: Figure 2 from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Figure 2 from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Microvascular and tumor cell biology at the tumor rim in U87MG glioblastoma. Representative histologic sections of rat brains, intrastriatally injected with U87MG tumor cells, from the tumor core, tumor rim, and the contralateral striatum,…
View article: Figure 2 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Figure 2 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
A, Mean NMR spectra for samples from unwell patients with either confirmed solid tumor diagnoses (red, n = 17) or confirmed noncancer diagnoses (black, n = 175). B, Difference spectrum showing regions that were …
View article: Figure 1 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Figure 1 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
Study schematic showing patient recruitment into the study, exclusions, biofluid collection, and confirmed diagnoses.
View article: Figure 3 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Figure 3 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
A, OPLS-DA plot showing separation of unwell patients with solid tumor diagnoses (blue, filled) from unwell patients with noncancer diagnoses (black, open). B, Sensitivity (dots), specificity (dashes), and F1 score…
View article: Figure 5 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Figure 5 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
Example patient journeys showing how metabolomics and multidisciplinary diagnostic center workup provided different diagnoses.
View article: Figure 6 from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Figure 6 from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Peritumoral vasculature is characterized by upregulated endothelial VCAM-1 expression. Representative histologic sections of peritumoral brain tissue, from breast cancer (A), lung adenocarcinoma (B), and melanoma brain metast…
View article: Tumor‐infiltrating lymphocyte therapy and the mucosal melanoma treatment landscape
Tumor‐infiltrating lymphocyte therapy and the mucosal melanoma treatment landscape Open
View article: Classification of glioma grade and Ki-67 level prediction in MRI data: A SHAP-driven interpretation
Classification of glioma grade and Ki-67 level prediction in MRI data: A SHAP-driven interpretation Open
This study focuses on artificial intelligence-driven classification of glioma and Ki-67 leveling using T2w-FLAIR MRI, exploring the association of Ki-67 biomarkers with deep learning (DL) features through explainable artificial intelligenc…
View article: Investigation of relayed nuclear Overhauser enhancement effect at −1.6 ppm in an ischemic stroke model
Investigation of relayed nuclear Overhauser enhancement effect at −1.6 ppm in an ischemic stroke model Open
Using CEST coupled with ADC and CBF, the ischemic tissue may thus potentially be separated into four zones to better understand the pathophysiology after stroke and improve ischemic tissue fate definition. Further verification of the poten…
View article: Post-stroke rapamycin treatment improves post-recanalization cerebral blood flow and outcome in rats
Post-stroke rapamycin treatment improves post-recanalization cerebral blood flow and outcome in rats Open
Ischaemic stroke treatment is limited to recanalizing the occluded vessel, while there is no approved adjunctive cerebroprotective therapy to protect either the neurons and parenchyma or the neurovascular unit. Pharmacological inhibition o…
View article: Issue Information: Astron. Nachr. 08/2023
Issue Information: Astron. Nachr. 08/2023 Open
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View article: Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using α <sub>v</sub> β <sub>3</sub> ‐targeted iron oxide microparticles
Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using α <sub>v</sub> β <sub>3</sub> ‐targeted iron oxide microparticles Open
Brain metastasis is responsible for a large proportion of cancer mortality, and there are currently no effective treatments. Moreover, the impact of treatments, particularly antiangiogenic therapeutics, is difficult to ascertain using curr…
View article: Supplementary material and methods and Tables 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Supplementary material and methods and Tables 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
Supplementary material and methods. Supplementary table 1: cell lines and growth conditions. Supplementary table 2: Notch ligands and control protein for plate coating. Supplementary table 3: qPCR primers. Supplementary table 4: flow cytom…
View article: Supplementary Figures 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Supplementary Figures 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
1: JAG1 antibody characterization. 2: antibody inhibition of JAG1 mediated Notch signalling in tumor cell lines. 3: antibody inhibition of JAG1 signalling in vascular cells. 4: antibody inhibition of JAG1 signalling in HUVEC-HUVSMC co-cult…
View article: Supplementary Figures 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Supplementary Figures 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
1: JAG1 antibody characterization. 2: antibody inhibition of JAG1 mediated Notch signalling in tumor cell lines. 3: antibody inhibition of JAG1 signalling in vascular cells. 4: antibody inhibition of JAG1 signalling in HUVEC-HUVSMC co-cult…
View article: Data from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Data from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology has been firmly established, making them appealing therapeutic targets for cancer treatment. Here, we report the development and characterization of human/rat-speci…
View article: Supplementary material and methods and Tables 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Supplementary material and methods and Tables 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
Supplementary material and methods. Supplementary table 1: cell lines and growth conditions. Supplementary table 2: Notch ligands and control protein for plate coating. Supplementary table 3: qPCR primers. Supplementary table 4: flow cytom…
View article: Data from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Data from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy Open
The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology has been firmly established, making them appealing therapeutic targets for cancer treatment. Here, we report the development and characterization of human/rat-speci…
View article: Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
Purpose:Early diagnosis of cancer is critical for improving patient outcomes, but cancers may be hard to diagnose if patients present with nonspecific signs and symptoms. We have previously shown that nuclear magnetic resonance (NMR) metab…
View article: Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Purpose:Despite optimal local therapy, tumor cell invasion into normal brain parenchyma frequently results in recurrence in patients with solid tumors. The aim of this study was to determine whether microvascular inflammation can be target…
View article: Supplementary Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Supplementary Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
View article: Data from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Data from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction Open
Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphologic changes in response to brain metastasis, switching to a reactive phenotype, w…
View article: Figure S6 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Figure S6 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction Open
Additional info regarding OX42
View article: Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Purpose:Despite optimal local therapy, tumor cell invasion into normal brain parenchyma frequently results in recurrence in patients with solid tumors. The aim of this study was to determine whether microvascular inflammation can be target…
View article: Data from Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging
Data from Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging Open
Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet mul…
View article: Supplementary Info from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Supplementary Info from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction Open
Supplementary Methods, Figure Legends and Tables
View article: Supplementary Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Supplementary Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
Supplementary Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
View article: Supplementary Table from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Table from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface Open
Supplementary Table from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
View article: Figure S4 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Figure S4 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction Open
Additional info regarding colocalisation studies
View article: Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms Open
Purpose:Early diagnosis of cancer is critical for improving patient outcomes, but cancers may be hard to diagnose if patients present with nonspecific signs and symptoms. We have previously shown that nuclear magnetic resonance (NMR) metab…