James R. Platt
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View article: CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer
CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer Open
Objectives In the Fluorouracil, Oxaliplatin and Targeted Receptor pre-Operative Therapy (FOxTROT) trial, neoadjuvant chemotherapy (NAC) significantly reduced recurrence risk, compared to upfront surgery, in locally advanced colon cancer. T…
View article: Safe prescribing in cancer patients during the <scp>COVID</scp>‐19 pandemic and outcomes following restart of cancer care following <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection: The <scp>COV</scp>‐<scp>SPOT</scp> initiative
Safe prescribing in cancer patients during the <span>COVID</span>‐19 pandemic and outcomes following restart of cancer care following <span>SARS</span>‐<span>CoV</span>‐2 infection: The <span>COV</span>‐<span>SPOT</span> initiative Open
SARS‐CoV‐2 continues to spread across the world as a highly transmissible endemic disease. For many cancer patients, SARS‐CoV‐2 infection is unavoidable. It continues to disrupt cancer care, causing treatment delays and major psycho‐socio‐…
View article: Colon cancer biology and treatment in the era of precision oncology: A primer for Radiologists
Colon cancer biology and treatment in the era of precision oncology: A primer for Radiologists Open
In the era of precision oncology, systemic therapies for colon cancer are becoming increasingly biomarker-led, with implications for patients in the neoadjuvant, adjuvant and metastatic settings. As the landscape for colon cancer treatment…
View article: Risk of bowel obstruction in patients with colon cancer responding to immunotherapy: an international case series
Risk of bowel obstruction in patients with colon cancer responding to immunotherapy: an international case series Open
Bowel obstruction associated with immunotherapy response may represent a rare treatment-related complication in dMMR CC. Clinicians must recognise this safety signal and share experience to maintain patient safety.
View article: The impact of mismatch repair status and systemic inflammatory markers on radiological staging in colon cancer
The impact of mismatch repair status and systemic inflammatory markers on radiological staging in colon cancer Open
Objective: Mismatch repair (MMR) deficient (dMMR) colon cancer (CC) is distinct from MMR proficient (pMMR) CC, yet the impact of MMR status on radiological staging is unclear. The purpose of this study was to investigate how MMR status imp…
View article: A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP)
A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) Open
View article: The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research Open
View article: Personalizing neoadjuvant chemotherapy for locally advanced colon cancer: protocols for the international phase <scp>III FOxTROT2</scp> and <scp>FOxTROT3 randomized controlled</scp> trials
Personalizing neoadjuvant chemotherapy for locally advanced colon cancer: protocols for the international phase <span>III FOxTROT2</span> and <span>FOxTROT3 randomized controlled</span> trials Open
Aim FOxTROT1 established a new standard of care for managing locally advanced colon cancer (CC) with neoadjuvant chemotherapy (NAC). Six weeks of neoadjuvant oxaliplatin and fluoropyrimidine (OxFp) chemotherapy was associated with greater …
View article: Association of SARS-CoV-2 Spike Protein Antibody Vaccine Response With Infection Severity in Patients With Cancer
Association of SARS-CoV-2 Spike Protein Antibody Vaccine Response With Infection Severity in Patients With Cancer Open
Importance Accurate identification of patient groups with the lowest level of protection following COVID-19 vaccination is important to better target resources and interventions for the most vulnerable populations. It is not known whether …
View article: FOxTROT2: innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty
FOxTROT2: innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty Open
View article: Safe prescribing in cancer patients during the <scp>COVID</scp>‐19 pandemic: A new initiative from the <scp>UK</scp> Cancer Coronavirus Project (<scp>UKCCP</scp>) team
Safe prescribing in cancer patients during the <span>COVID</span>‐19 pandemic: A new initiative from the <span>UK</span> Cancer Coronavirus Project (<span>UKCCP</span>) team Open
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View article: COVID-19: Third dose booster vaccine effectiveness against breakthrough coronavirus infection, hospitalisations and death in patients with cancer: A population-based study
COVID-19: Third dose booster vaccine effectiveness against breakthrough coronavirus infection, hospitalisations and death in patients with cancer: A population-based study Open
View article: Vaccine effectiveness against COVID-19 breakthrough infections in patients with cancer (UKCCEP): a population-based test-negative case-control study
Vaccine effectiveness against COVID-19 breakthrough infections in patients with cancer (UKCCEP): a population-based test-negative case-control study Open