James E. Redman
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View article: Crystal structures of sulfonamide protected bicyclic guanidines: (<i>S</i>)-8-{[(<i>tert</i>-butyldimethylsilyl)oxy]methyl}-1-[(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl]-1,3,4,6,7,8-hexahydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-1-ium trifluoromethanesulfonate and (<i>S</i>)-8-(iodomethyl)-1-tosyl-1,3,4,6,7,8-hexahydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-1-ium iodide
Crystal structures of sulfonamide protected bicyclic guanidines: (<i>S</i>)-8-{[(<i>tert</i>-butyldimethylsilyl)oxy]methyl}-1-[(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl]-1,3,4,6,7,8-hexahydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-1-ium trifluoromethanesulfonate and (<i>S</i>)-8-(iodomethyl)-1-tosyl-1,3,4,6,7,8-hexahydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-1-ium iodide Open
Two compounds, ( S )-8-{[( tert -butyldimethylsilyl)oxy]methyl}-1-[(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl]-1,3,4,6,7,8-hexahydro-2 H -pyrimido[1,2- a ]pyrimidin-1-ium trifluoromethanesulfonate, C 27 H 46 N 3 O 4 SSi + ·…
View article: Data from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Data from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are esophageal squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomar…
View article: Figure S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Cumulative IHC scoring for normal esophagus from ESCC patients (NT) and ESCC (T) matched samples. CCL18 showed no statistical difference in staining between sample groups but TNC was significantly over-expressed in tumour samples (p<0.0002…
View article: Table S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Table S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Antibodies used and the conditions for immunohistochemistry.
View article: Figure S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Cumulative IHC scoring for normal esophagus from ESCC patients (NT) and ESCC (T) matched samples. CCL18 showed no statistical difference in staining between sample groups but TNC was significantly over-expressed in tumour samples (p<0.0002…
View article: Figure S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Representative examples of SVM separation score data selected from the 100 genes with the highest SVM scores using a random number generator. The x-axis shows the sample number; normal samples are on the left of each graph, tumour samples …
View article: Figure S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Representative examples of SVM separation score data selected from the 100 genes with the highest SVM scores using a random number generator. The x-axis shows the sample number; normal samples are on the left of each graph, tumour samples …
View article: Table S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Table S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Summary of known the functions and roles in cancer of the 20 genes overexpressed in tumour compared to normal tissue from normal patients. The p value indicates the level of significance for the difference in expression between normal from…
View article: Figure S3 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S3 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Representative images of immunohistochemistry staining for normal esophagus from ESCC patients (NT) and ESCC samples (T) for genes CTSL, TNC and COL3A1 at 100x magnification.
View article: Table S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Table S2 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Summary of known the functions and roles in cancer of the 20 genes overexpressed in tumour compared to normal tissue from normal patients. The p value indicates the level of significance for the difference in expression between normal from…
View article: Data from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Data from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are esophageal squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomar…
View article: Table S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Table S1 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Antibodies used and the conditions for immunohistochemistry.
View article: Figure S3 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Figure S3 from The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
Representative images of immunohistochemistry staining for normal esophagus from ESCC patients (NT) and ESCC samples (T) for genes CTSL, TNC and COL3A1 at 100x magnification.
View article: Explorations into Peptide Nucleic Acid Contrast Agents as Emerging Scaffolds for Breakthrough Solutions in Medical Imaging and Diagnosis
Explorations into Peptide Nucleic Acid Contrast Agents as Emerging Scaffolds for Breakthrough Solutions in Medical Imaging and Diagnosis Open
Peptide nucleic acids (PNAs, nucleic acid analogues with a peptide backbone rather than a phosphoribosyl backbone) have emerged as promising chemical agents in antigene or antisense therapeutics, as splicing modulators or in gene editing. …
View article: Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells
Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells Open
The human CD8+ T cell clone 6C5 has previously been shown to recognize the tert-butyl-modified Bax161–170 peptide LLSY(3-tBu)FGTPT presented by HLA-A*02:01. This nonnatural epitope was likely created as a by-product of fluorenylmethoxycarb…
View article: Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes
Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes Open
In this study we have developed an electrochemical microRNA biosensor sensitive to 17 fM and capable of detecting an established downregulation of urinary miR-192 in diabetic kidney disease patients.
View article: A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma
A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma Open
Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression are essential to optimize resource utilization. This study assessed the utility of a promi…
View article: The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma Open
The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are esophageal squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomar…