James Rioux
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View article: T1ρ$$ {}_{1\rho } $$ as a Biomarker for IDH1 Mutation Status in a Glioma Mouse Model
T1ρ$$ {}_{1\rho } $$ as a Biomarker for IDH1 Mutation Status in a Glioma Mouse Model Open
Glioma is a common and often aggressive malignant brain cancer for which treatment is in part dependent on the mutation status of the IDH gene. Current diagnostic methods require a biopsy and genetic analysis to obtain IDH status, which ca…
View article: Radiomics in preclinical imaging research: methods, challenges and opportunities
Radiomics in preclinical imaging research: methods, challenges and opportunities Open
Radiomics-based analyses are increasingly being applied to clinical studies. Radiomic features can be correlated with markers of disease severity or treatment success to improve early detection of disease and develop predictive models for …
View article: Nonuniform sliding-window reconstruction for accelerated dual contrast agent quantification with MR fingerprinting
Nonuniform sliding-window reconstruction for accelerated dual contrast agent quantification with MR fingerprinting Open
Objective MR fingerprinting (MRF) can enable preclinical studies of cell tracking by quantifying multiple contrast agents simultaneously, but faster scan times are required for in vivo applications. Sliding window (SW)-MRF is one option fo…
View article: Use of Magnetotactic Bacteria as an MRI Contrast Agent for In Vivo Tracking of Adoptively Transferred Immune Cells
Use of Magnetotactic Bacteria as an MRI Contrast Agent for In Vivo Tracking of Adoptively Transferred Immune Cells Open
Purpose In vivo immune cell tracking using MRI is a valuable tool for studying the mechanisms underlying successful cancer therapies. Current cell labeling methods using superparamagnetic iron oxide (SPIO) lack the specificity and persiste…
View article: Evaluation of Golden-Angle-Sampled Dynamic Contrast-Enhanced MRI Reconstruction Using Objective Image Quality Measures: A Simulated Phantom Study
Evaluation of Golden-Angle-Sampled Dynamic Contrast-Enhanced MRI Reconstruction Using Objective Image Quality Measures: A Simulated Phantom Study Open
We aim to extend the use of image quality metrics (IQMs) from static magnetic resonance imaging (MRI) applications to dynamic MRI studies. We assessed the use of 2 IQMs, the root mean square error and structural similarity index, in evalua…
View article: Mapping of fatty acid composition with free‐breathing MR spectroscopic imaging and compressed sensing
Mapping of fatty acid composition with free‐breathing MR spectroscopic imaging and compressed sensing Open
Nonalcoholic fatty liver disease (NAFLD) is a growing health problem, and a major challenge in NAFLD management is identifying which patients are at risk of progression to more serious disease. Simple measurements of liver fat content are …
View article: Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy
Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy Open
DPX is a unique T cell activating formulation that generates robust immune responses (both clinically and preclinically) which can be tailored to various cancers via the use of tumor-specific antigens and adjuvants. While DPX-based immunot…
View article: Comparison of Objective Image Quality Metrics to Expert Radiologists’ Scoring of Diagnostic Quality of MR Images
Comparison of Objective Image Quality Metrics to Expert Radiologists’ Scoring of Diagnostic Quality of MR Images Open
Image quality metrics (IQMs) such as root mean square error (RMSE) and structural similarity index (SSIM) are commonly used in the evaluation and optimization of accelerated magnetic resonance imaging (MRI) acquisition and reconstruction s…
View article: Cell Density Quantification with TurboSPI: R2* Mapping with Compensation for Off-Resonance Fat Modulation
Cell Density Quantification with TurboSPI: R2* Mapping with Compensation for Off-Resonance Fat Modulation Open
Tracking the migration of superparamagnetic iron oxide (SPIO) labeled immune cells in vivo is valuable for understanding the immunogenic response to cancer and therapies. Quantitative cell tracking using compressed sensing TurboSPI-based R…