James Robert Brašić
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View article: The Safety and Efficacy of Glibenclamide in Managing Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis
The Safety and Efficacy of Glibenclamide in Managing Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis Open
Background/Objectives: We sought to determine if glibenclamide, a sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel blocker, reduces cerebral edema and improves neurological functioning in aneurysmal su…
View article: Optimization and individualization of dual antiplatelet therapy strategies for older patients with mild to moderate ischemic stroke: a meta-analysis
Optimization and individualization of dual antiplatelet therapy strategies for older patients with mild to moderate ischemic stroke: a meta-analysis Open
Although many interventions have been proposed to reduce morbidity and mortality following a transient ischemic attack or ischemic stroke, the optimal procedure is controversial. Since dual antiplatelet therapy with clopidogrel and aspirin…
View article: The Impact of Periprocedural Prosthetic Valve Leak After Transcatheter Aortic Valve Implantation
The Impact of Periprocedural Prosthetic Valve Leak After Transcatheter Aortic Valve Implantation Open
A periprocedural prosthetic valve leak (PVL) after transcatheter aortic valve implantation (TAVI), a minimally invasive treatment modality for patients with severe, symptomatic aortic stenosis, may entail serious morbidity. Cohorts hospita…
View article: The Efficacy of Medical Interventions for Free-Floating Thrombus in Cerebrovascular Events: A Systematic Review
The Efficacy of Medical Interventions for Free-Floating Thrombus in Cerebrovascular Events: A Systematic Review Open
Although free-floating thrombus (FFT) poses a significant risk of stroke or transient ischemic attack (TIA), optimal management strategies are uncertain. To determine the state-of-the-art of medical interventions for FFT, we conducted a sy…
View article: Oncolytic Viral Therapy with Gravity Approaching Zero to Ameliorate Glioblastoma Multiforme
Oncolytic Viral Therapy with Gravity Approaching Zero to Ameliorate Glioblastoma Multiforme Open
Glioblastoma multiforme (GBM) is the most common aggressive malignant primary brain tumor, afflicting approximately 3 in every 100,000 persons in the United States, with an incidence rate that is 1 [...]
View article: Optimal Antithrombotic Regimen After Cryptogenic Stroke: A Systematic Review and Network Meta-Analysis
Optimal Antithrombotic Regimen After Cryptogenic Stroke: A Systematic Review and Network Meta-Analysis Open
Although several antithrombotic strategies have been investigated for the management of cryptogenic strokes, ie, ischemic strokes without known etiologies, an optimal antithrombotic strategy for cryptogenic strokes is unknown. We aim to as…
View article: Istaroxime for Patients with Acute Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Istaroxime for Patients with Acute Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Istaroxime, an intravenous inotropic agent with a dual mechanism—increasing both cardiomyocyte contractility and relaxation—is a novel treatment for acute heart failure (AHF), the leading cause of morbidity and mortality in heart failure. …
View article: A Deep Learning Approach for Automatic and Objective Grading of the Motor Impairment Severity in Parkinson’s Disease for Use in Tele-Assessments
A Deep Learning Approach for Automatic and Objective Grading of the Motor Impairment Severity in Parkinson’s Disease for Use in Tele-Assessments Open
Wearable sensors provide a tool for at-home monitoring of motor impairment progression in neurological conditions such as Parkinson’s disease (PD). This study examined the ability of deep learning approaches to grade the motor impairment s…
View article: Corrigendum to “Feasibility of virtual low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson's disease” [MethodsX 11 (2023) 102230]
Corrigendum to “Feasibility of virtual low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson's disease” [MethodsX 11 (2023) 102230] Open
[This corrects the article DOI: 10.1016/j.mex.2023.102230.].
View article: Contact Force-Guided versus Contact Force-Blinded Cavo-Tricuspid Isthmus Ablation for Atrial Flutter: A Systematic Review and Meta-Analysis
Contact Force-Guided versus Contact Force-Blinded Cavo-Tricuspid Isthmus Ablation for Atrial Flutter: A Systematic Review and Meta-Analysis Open
Contact force (CF) is a novel approach developed to increase the safety and efficacy of catheter ablation. However, the value of CF-sensing technology for atrial flutter (AFL) cavo-tricuspid isthmus ablation (CTIA) is inconclusive. To gene…
View article: Milkshake Acutely Stimulates Dopamine Release in Ventral and Dorsal Striatum in Healthy-Weight Individuals and Patients with Severe Obesity Undergoing Bariatric Surgery: A Pilot Study
Milkshake Acutely Stimulates Dopamine Release in Ventral and Dorsal Striatum in Healthy-Weight Individuals and Patients with Severe Obesity Undergoing Bariatric Surgery: A Pilot Study Open
The overconsumption of palatable energy-dense foods drives obesity, but few human studies have investigated dopamine (DA) release in response to the consumption of a palatable meal, a putative mediator of excess intake in obesity. We image…
View article: Amelioration of Glioblastoma Multiforme via the Combination of Simulated Microgravity and Oncolytic Viral Therapy
Amelioration of Glioblastoma Multiforme via the Combination of Simulated Microgravity and Oncolytic Viral Therapy Open
Glioblastoma multiforme (GBM) is the most common aggressive malignant primary brain tumor, afflicting approximately 3.19 per 100,000 persons in the United States with an incidence 1.6 times higher in males compared to females. Arising from…
View article: Research Trends of Vitamin D Metabolism Gene Polymorphisms Based on a Bibliometric Investigation
Research Trends of Vitamin D Metabolism Gene Polymorphisms Based on a Bibliometric Investigation Open
Vitamin D requires activation to show its pharmacological effect. While most studies investigate the association between vitamin D and disease, only a few focus on the impact of vitamin D metabolism gene polymorphisms (vitDMGPs). This bibl…
View article: Replication Data for: Research trends of vitamin D metabolism gene polymorphisms based on a bibliometric investigation
Replication Data for: Research trends of vitamin D metabolism gene polymorphisms based on a bibliometric investigation Open
Combined raw data used for CiteSpace©, Bibliometrix©, and VOSviewer© to create the bibliometric map and cluster timeline
View article: The Efficacy and Safety of Direct Oral Anticoagulants versus Standard of Care in Patients without an Indication of Anti-Coagulants after Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Controlled Trials
The Efficacy and Safety of Direct Oral Anticoagulants versus Standard of Care in Patients without an Indication of Anti-Coagulants after Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Controlled Trials Open
Transcatheter aortic valve replacement (TAVR) is now considered the mainstay of aortic stenosis management; however, the optimal antithrombotic therapy in patent without indications for an oral anticoagulant (OAC) is yet to be identified. …
View article: Tic Reduction Following Heat-Induced Dehydration in Gilles de la Tourette Syndrome (TS)
Tic Reduction Following Heat-Induced Dehydration in Gilles de la Tourette Syndrome (TS) Open
A 24-year-old man with of Gilles de la Tourette (TS) syndrome experienced a marked remission of 2 years after heat-induced dehydration. Further investigation of the effects of heat and dehydration on TS may be useful.
View article: Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Helicobacter pylori (H. pylori) is the most prevalent etiology of gastritis worldwide. H. pylori management depends mainly on antibiotics, especially the triple therapy formed of clarithromycin, amoxicillin, and proton pump inhibitors. Lat…
View article: The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Irritable bowel syndrome (IBS), a gastrointestinal disorder affecting 7–12% of the population, is characterized by abdominal pain, bloating, and alternating bowel patterns. Data on risk and protective influences have yielded conflicting ev…
View article: Reply to Aljabali et al. Comment on “Abbas et al. The Safety and Efficacy of Nusinersen in the Treatment of Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina 2022, 58, 213”
Reply to Aljabali et al. Comment on “Abbas et al. The Safety and Efficacy of Nusinersen in the Treatment of Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina 2022, 58, 213” Open
We appreciate Ahmed Sami Aljabali and his colleagues for their interest and comments [...]
View article: Heat induced reduction of tics for Gilles de la Tourette Syndrome
Heat induced reduction of tics for Gilles de la Tourette Syndrome Open
Patients with Gilles de la Tourette syndrome (GTS) may exhibit decrements or increments of tics with heat. A 25 year old male presented for evaluation. Since 7 years of age, he experienced motor and phonic tics. At age 23 year, 5 months, h…
View article: Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study
Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study Open
Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) in the pathogenesis of fragile X syndrome (FXS), the most co…
View article: The Safety and Efficacy of Nusinersen in the Treatment of Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The Safety and Efficacy of Nusinersen in the Treatment of Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background and objectives: Spinal muscular atrophy (SMA) is a neurodegenerative disease that leads to progressive proximal muscle weakness and muscle atrophy. To assess the beneficial and adverse effects of nusinersen, a promising interven…
View article: Fragile X Mental Retardation Protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: a pilot study
Fragile X Mental Retardation Protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: a pilot study Open
Legends. Fragile X Mental Retardation Protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: a pilot study Table S1. Concomitant medications of participants from the Institute for Neuro…