James S. Pankow
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View article: Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis Open
View article: Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey
Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey Open
Background Although periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease me…
View article: Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia
Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia Open
View article: Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study
Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study Open
Background Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory hospitalizations and deaths, and all-cause mortality. Proteomics may provide further insights i…
View article: Detecting hyperglycemia using biomarkers versus continuous glucose monitoring
Detecting hyperglycemia using biomarkers versus continuous glucose monitoring Open
Objective: To evaluate the concordance of glycated albumin, fructosamine, 1,5-anhydroglucitol (1,5-AG), and HbA1c with continuous glucose monitor (CGM) metrics of hyperglycemia and glycemic control in a diverse population of adults with ty…
View article: Detecting hyperglycemia using biomarkers versus continuous glucose monitoring
Detecting hyperglycemia using biomarkers versus continuous glucose monitoring Open
Objective: To evaluate the concordance of glycated albumin, fructosamine, 1,5-anhydroglucitol (1,5-AG), and HbA1c with continuous glucose monitor (CGM) metrics of hyperglycemia and glycemic control in a diverse population of adults with ty…
View article: Reverse translational target nomination identifies DLK1 as a potential protective factor in atrial myopathy
Reverse translational target nomination identifies DLK1 as a potential protective factor in atrial myopathy Open
View article: Effects of hearing intervention on falls in older adults: findings from a secondary analysis of the ACHIEVE randomised controlled trial
Effects of hearing intervention on falls in older adults: findings from a secondary analysis of the ACHIEVE randomised controlled trial Open
View article: Reply: Comment on “Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis”
Reply: Comment on “Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis” Open
View article: Hearing Intervention, Social Isolation, and Loneliness
Hearing Intervention, Social Isolation, and Loneliness Open
Importance Promoting social connection among older adults is a public health priority. Addressing hearing loss may reduce social isolation and loneliness among older adults. Objective To describe the effect of a best-practice hearing inter…
View article: DNA methylation markers of insulin resistance surrogate measures in the Atherosclerosis Risk in Communities (ARIC) study
DNA methylation markers of insulin resistance surrogate measures in the Atherosclerosis Risk in Communities (ARIC) study Open
Insulin resistance (IR) is a risk factor for cardiovascular diseases and type 2 diabetes. Associations between DNA methylation (DNAm) and IR have been less studied in African ancestry (AA) populations than those of European ancestry (EA). …
View article: Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial
Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial Open
INTRODUCTION Results from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial suggest hearing intervention may not reduce 3‐year cognitive decline in all older adults with hearing loss but may be beneficial in certain group…
View article: Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele Open
View article: Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants
Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants Open
View article: Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the <scp>ACHIEVE</scp> Study
Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the <span>ACHIEVE</span> Study Open
Background Hearing loss is prevalent in older adults and is associated with reduced daily physical activity, but whether hearing intervention attenuates declines in physical activity is unknown. We investigated the 3‐year effect of a heari…
View article: Measuring weak effects in high dimensional mediation analysis
Measuring weak effects in high dimensional mediation analysis Open
Existing mediation analysis methods have often fallen short in accurately quantifying the contribution of omics mediators, particularly those with weak effects. To address this issue, we propose two new variance-based causal measures for t…
View article: Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population‐based studies
Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population‐based studies Open
Contains fulltext : 318280.pdf (Publisher’s version ) (Open Access)
View article: Proteomics-based aging clocks in midlife and late-life and risk of dementia
Proteomics-based aging clocks in midlife and late-life and risk of dementia Open
View article: The Association between Proteomic Aging Clocks and the Risk of Cancer in Midlife Individuals
The Association between Proteomic Aging Clocks and the Risk of Cancer in Midlife Individuals Open
Background To measure the aging process before a cancer diagnosis, we developed the first cancer-specific proteomic aging clock (CaPAC) and examined its association with cancer risk in the Atherosclerosis Risk in Communities (ARIC) and Mul…
View article: Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis
Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis Open
Our findings illustrate participants with 2021 eGFR < 60 compared with those with eGFR > 90 mL/min/1.73 m2 have higher risk of dementia in both African American and non-African American participants, but not of stroke.
View article: Effect of hearing intervention on three‐year change in brain morphology
Effect of hearing intervention on three‐year change in brain morphology Open
Background Prior longitudinal studies among older adults have documented associations between hearing loss and changes in brain morphology. Whether interventions involving hearing aids can reduce age‐related atrophy is unknown. A substudy …
View article: Effect of a hearing intervention on 3‐year cognitive change is greater among older adults at high risk of cognitive decline: ACHIEVE randomized trial
Effect of a hearing intervention on 3‐year cognitive change is greater among older adults at high risk of cognitive decline: ACHIEVE randomized trial Open
Background The Aging and Cognitive Health Evaluation in Elders (ACHIEVE, Clinicaltrials.gov Identifier: NCT03243422) randomized trial investigated the effect of hearing intervention versus health education control on 3‐year cognitive chang…
View article: A Hearing Intervention and Health-Related Quality of Life in Older Adults
A Hearing Intervention and Health-Related Quality of Life in Older Adults Open
Importance Health-related quality of life is a critical health outcome and a clinically important patient-reported outcome in clinical trials. Hearing loss is associated with poorer health-related quality-of-life in older adults. Objective…
View article: Multimodal data integration to predict atrial fibrillation
Multimodal data integration to predict atrial fibrillation Open
Aims Many studies have utilized data sources such as clinical variables, polygenic risk scores, electrocardiogram (ECG), and plasma proteins to predict the risk of atrial fibrillation (AF). However, few studies have integrated all four sou…
View article: A Hearing Intervention and Health-Related Quality of Life in Older Adults
A Hearing Intervention and Health-Related Quality of Life in Older Adults Open
Importance: Health-related quality of life is a critical health outcome and a clinically important patient-reported outcome in clinical trials. Hearing loss is associated with poorer health-related quality-of-life in older adults. Objectiv…
View article: Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts
Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts Open
Background Biological age may be estimated by proteomic aging clocks (PACs). Previous published PACs were constructed either in smaller studies or mainly in white individuals, and they used proteomic measures from only one-time point. In t…
View article: Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis
Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis Open
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF). We sought to identify plasma proteins cross‐sectionally asso…
View article: Effect of hearing intervention on communicative function: A secondary analysis of the <scp>ACHIEVE</scp> randomized controlled trial
Effect of hearing intervention on communicative function: A secondary analysis of the <span>ACHIEVE</span> randomized controlled trial Open
Background The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Study was designed to determine the effects of a best‐practice hearing intervention on cognitive decline among community‐dwelling older adults. Here, we conducted a s…
View article: Effect of hearing intervention on communicative function: A secondary analysis of the ACHIEVE randomized controlled trial
Effect of hearing intervention on communicative function: A secondary analysis of the ACHIEVE randomized controlled trial Open
BACKGROUND: The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Study was designed to determine the effects of a best-practice hearing intervention on cognitive decline among community-dwelling older adults. Here, we conducted a …
View article: LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes Open