James Stampley
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View article: Advances and limitations of semi-elastic pneumatic cuffs in blood flow restriction training: a narrative review
Advances and limitations of semi-elastic pneumatic cuffs in blood flow restriction training: a narrative review Open
Semi-elastic pneumatic (SEP) blood flow restriction (BFR) cuffs, such as the original KAATSU and the B Strong/B3 cuffs, have gained popularity as practical, user-friendly tools for low-load BFR exercise. However, their efficacy and optimal…
View article: Ketone monoester ingestion preserves working memory during loaded exercise in the heat
Ketone monoester ingestion preserves working memory during loaded exercise in the heat Open
Background Special Operations Forces (SOF) often operate in extreme heat, where sustained physical exertion may degrade cognition. Exercise-heat stress can reduce cerebral blood flow (CBF) and oxygenation, increasing the risk of catastroph…
View article: Beta-hydroxybutyrate ingestion with caffeine improves time to exhaustion performance following loaded exercise in the heat
Beta-hydroxybutyrate ingestion with caffeine improves time to exhaustion performance following loaded exercise in the heat Open
Background Special Operations Forces operate in hot conditions under heavy loads, which impairs thermoregulation and performance and risks mission success. Exogenous ketone monoesters, such as beta-hydroxybutyrate (BHB), may enhance cerebr…
View article: Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction
Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction Open
View article: Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer’s model
Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer’s model Open
Reduced nitric oxide (NO) bioavailability is a pathological link between obesity and Alzheimer's disease (AD). Obesity-associated metabolic and mitochondrial bioenergetic dysfunction are key drivers of AD pathology. The hypothalamus is a c…
View article: Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF
Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF Open
Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a "2-hit" model of HFpEF, we investigated the ability …
View article: Impact of low‐load resistance exercise with and without blood flow restriction on muscle strength, endurance, and oxidative capacity: A pilot study
Impact of low‐load resistance exercise with and without blood flow restriction on muscle strength, endurance, and oxidative capacity: A pilot study Open
Low‐load resistance exercise (LLRE) to failure can increase muscle mass, strength, endurance, and mitochondrial oxidative capacity (OXPHOS). However, the impact of adding blood flow restriction to low‐load resistance exercise (LLBFR) when …
View article: Acute Exercise Increases NK Cell Mitochondrial Respiration and Cytotoxicity against Triple-Negative Breast Cancer Cells under Hypoxic Conditions
Acute Exercise Increases NK Cell Mitochondrial Respiration and Cytotoxicity against Triple-Negative Breast Cancer Cells under Hypoxic Conditions Open
Purpose Triple-negative breast cancer (TNBC) is an aggressive, highly metastatic malignancy with high recurrence rates. Hypoxia is a hallmark of the TNBC tumor microenvironment, which promotes tumor growth while impairing natural killer (N…
View article: Impact of maximal exercise on immune cell mobilization and bioenergetics
Impact of maximal exercise on immune cell mobilization and bioenergetics Open
Acute aerobic exercise increases the number and proportions of circulating peripheral blood mononuclear cells (PMBC) and can alter PBMC mitochondrial bioenergetics. In this study, we aimed to examine the impact of a maximal exercise bout o…
View article: Monitoring body composition change for intervention studies with advancing 3D optical imaging technology in comparison to dual-energy X-ray absorptiometry
Monitoring body composition change for intervention studies with advancing 3D optical imaging technology in comparison to dual-energy X-ray absorptiometry Open
View article: Monitoring Body Composition Change for Intervention Studies with Advancing 3D Optical Imaging Technology in Comparison to Dual-Energy X-Ray Absorptiometry
Monitoring Body Composition Change for Intervention Studies with Advancing 3D Optical Imaging Technology in Comparison to Dual-Energy X-Ray Absorptiometry Open
Background Recent three-dimensional optical (3DO) imaging advancements have provided more accessible, affordable, and self-operating opportunities for assessing body composition. 3DO is accurate and precise with respect to clinical measure…
View article: Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults
Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults Open
Regular exercise is associated with changes in peripheral blood mononuclear cell (PBMC) proportions that have enhanced effector functions in young and old adults; however, the effects of acute exercise on PBMC nutrient sensors and metaboli…
View article: Corrigendum to: Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence
Corrigendum to: Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence Open
View article: Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise
Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise Open
Circulating immune cell numbers and phenotypes are impacted by high-intensity acute bouts of exercise and infection history with the latent herpesviruses cytomegalovirus (CMV). In particular, CMV infection history impairs the exercise-indu…
View article: The Association between Poor Diet Quality, Physical Fatigability and Physical Function in the Oldest-Old from the Geisinger Rural Aging Study
The Association between Poor Diet Quality, Physical Fatigability and Physical Function in the Oldest-Old from the Geisinger Rural Aging Study Open
More perceived physical fatigability and poor diet quality are associated with impairments in physical function in older adults. However, the degree to which more perceived fatigability explains the association between poor diet quality an…
View article: An Ethanolic Extract of Artemisia dracunculus L. Enhances the Metabolic Benefits of Exercise in Diet-induced Obese Mice
An Ethanolic Extract of Artemisia dracunculus L. Enhances the Metabolic Benefits of Exercise in Diet-induced Obese Mice Open
Purpose The purpose of this study was to determine the effect of an ethanolic extract of Artemisia dracunculus L. (5011) combined with exercise on in vivo glucose and fat metabolism in diet-induced obese male mice. Methods After 8 wk of hi…