James T. Lim
YOU?
Author Swipe
View article: Doppler-Guided Haemorrhoidal Artery Ligation and Rectoanal Repair (HAL-RAR): An Institutional Experience
Doppler-Guided Haemorrhoidal Artery Ligation and Rectoanal Repair (HAL-RAR): An Institutional Experience Open
Background: Doppler-guided haemorrhoidal artery ligation with rectoanal repair (HAL-RAR) is a minimally invasive alternative to conventional haemorrhoidectomy. While associated with reduced postoperative pain and quicker recovery, data on …
View article: The Impact of Obesity on Intraoperative Complications in Rectal Cancer
The Impact of Obesity on Intraoperative Complications in Rectal Cancer Open
Background Obesity is a growing global health concern and poses significant challenges in rectal cancer surgery. Excess visceral fat can obscure surgical landmarks, complicate dissection, and increase the risk of intraoperative adverse eve…
View article: Right hemicolectomy for colon cancer: does the anastomotic configuration affect short‐term outcomes?
Right hemicolectomy for colon cancer: does the anastomotic configuration affect short‐term outcomes? Open
Objectives Right hemicolectomy is a common colorectal operation for resection of cancers of the right colon. The ileocolic anastomosis may be created using a stapled end‐to‐side, stapled side‐to‐side or handsewn technique. Anastomotic leak…
View article: Mechanical bowel preparation with pre‐operative oral antibiotics in elective colorectal resections: an Australian single institution experience
Mechanical bowel preparation with pre‐operative oral antibiotics in elective colorectal resections: an Australian single institution experience Open
Background Anastomotic leaks (AL) and surgical site infections (SSI) are serious complications after colorectal resection. Studies have shown the benefits of pre‐operative oral antibiotics (OAB) with mechanical bowel preparation (MBP) in r…
View article: Data from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Data from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Despite significant progress in understanding the genetic landscape of T-cell acute lymphoblastic leukemia (T-ALL), the discovery of novel therapeutic targets has been difficult. Our results demonstrate that the levels of PIM1 protein kina…
View article: Table S4-5 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S4-5 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S4: GSEA curated canonical pathway enrichment (FDR<0.25) Table S5: GSEA oncogenic signature enrichment of AZDR1 compared to Naïve HSB-2 (FDR<0.25)
View article: Table S11-14 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S11-14 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S11: RPPA differential abundance in AZD1208 resistant compared to DMSO treated HSB-2 cells. Table S12: RPPA differential abundance in AZD-1µM (AZD1208 sensitive) compared to AZDR1 HSB-2 cells. Table S13: RPPA differential abundance i…
View article: Table S6-10 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S6-10 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S6:Functional enrichment of KEGG pathways in RNA-seq active module. Table S7: Testing for protein-protein interaction network bias in active module analysis with KEGG pathway functional enrichment (Trial 1). Table S8: Testing for pro…
View article: Table S11-14 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S11-14 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S11: RPPA differential abundance in AZD1208 resistant compared to DMSO treated HSB-2 cells. Table S12: RPPA differential abundance in AZD-1µM (AZD1208 sensitive) compared to AZDR1 HSB-2 cells. Table S13: RPPA differential abundance i…
View article: Supplementary Appendix file from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Supplementary Appendix file from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Supplementary Materials and Methods, Tables and References
View article: Table S4-5 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S4-5 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S4: GSEA curated canonical pathway enrichment (FDR<0.25) Table S5: GSEA oncogenic signature enrichment of AZDR1 compared to Naïve HSB-2 (FDR<0.25)
View article: Supplementary Appendix file from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Supplementary Appendix file from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Supplementary Materials and Methods, Tables and References
View article: Table S2-3 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S2-3 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S2: GO terms enriched from hierarchical clustering with optimal cut tree on differentially expressed (FDR<0.01) genes in AZDR1 compared to Naïve HSB-2. Table S3: GO terms enriched from hierarchical clustering with cut tree at h=2 on …
View article: Data from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Data from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Despite significant progress in understanding the genetic landscape of T-cell acute lymphoblastic leukemia (T-ALL), the discovery of novel therapeutic targets has been difficult. Our results demonstrate that the levels of PIM1 protein kina…
View article: Table S2-3 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S2-3 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S2: GO terms enriched from hierarchical clustering with optimal cut tree on differentially expressed (FDR<0.01) genes in AZDR1 compared to Naïve HSB-2. Table S3: GO terms enriched from hierarchical clustering with cut tree at h=2 on …
View article: Table S6-10 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Table S6-10 from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis Open
Table S6:Functional enrichment of KEGG pathways in RNA-seq active module. Table S7: Testing for protein-protein interaction network bias in active module analysis with KEGG pathway functional enrichment (Trial 1). Table S8: Testing for pro…
View article: Does intra‐operative humidification with warmed <scp>CO<sub>2</sub></scp> reduce surgical site infection in open colorectal surgery? A randomized control trial
Does intra‐operative humidification with warmed <span>CO<sub>2</sub></span> reduce surgical site infection in open colorectal surgery? A randomized control trial Open
Backgrounds Surgical site infections (SSI) are a significant cause of postoperative morbidity and mortality, contributing to a considerable financial burden on the healthcare system. Insufflation of the open surgical wound with warm, humid…
View article: Endoscopic and surgical management of acute haemorrhagic rectal ulcers
Endoscopic and surgical management of acute haemorrhagic rectal ulcers Open
Acute haemorrhagic rectal ulcers are rare causes of acute large volume gastrointestinal bleeding in critically unwell patients. Patients affected by this condition are usually elderly, poorly functioning and highly comorbid. This condition…
View article: Endoscopic Removal of a Fecalith or Fecomucolith in a Rectal Stump or Pouch
Endoscopic Removal of a Fecalith or Fecomucolith in a Rectal Stump or Pouch Open
Fecaliths or fecomucoliths can form in rectal stumps after a Hartmann procedure or in a coloneovaginal conduit. They can cause significant distress to the patient by causing symptoms such as discharge and odor. We describe a novel and effe…
View article: Intramucosal carcinoma with submucosal lymphatic invasion—a case series
Intramucosal carcinoma with submucosal lymphatic invasion—a case series Open
Since the implementation of the National Bowel Cancer Screening Program, there is a rise in detection of early colorectal cancer, with that the diagnosis of intramucosal carcinoma. Intramucosal carcinoma or carcinoma in situ (Tis) is a ter…