Thomas J. Smith
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View article: Automated phenotyping of congenital heart disease for dynamic patient aggregation and outcome reporting
Automated phenotyping of congenital heart disease for dynamic patient aggregation and outcome reporting Open
Objectives Accurate characterization of patients with congenital heart disease is fundamental to research, outcomes reporting, quality improvement, and clinical decision-making. Here we present an approach to computing the anatomy of patie…
View article: Notes on Contributors
Notes on Contributors Open
from 2019-22 and has published widely on the principality of Antioch and the political and cultural history of the crusader states, including a monograph, The Principality of Antioch and its Frontiers in the Twelfth Century (2017), three e…
View article: Vibrio fluvialis Bacteremia With Hemorrhagic Bullae: A Case Report
Vibrio fluvialis Bacteremia With Hemorrhagic Bullae: A Case Report Open
V. fluvialis is a pathogenic Gram-negative bacillus typically resulting in gastroenteritis in humans. It has recently been identified as a growing concern for public health. The case presented is an uncommon case of V. fluvialis causing ba…
View article: A critical appraisal of tools for delivery room assessment of the newborn infant
A critical appraisal of tools for delivery room assessment of the newborn infant Open
Assessment of an infant's condition in the delivery room represents a prerequisite to adequately initiate medical support. In her seminal paper, Virginia Apgar described five parameters to be used for such an assessment. However, since tha…
View article: Clinical Scene Segmentation with Tiny Datasets
Clinical Scene Segmentation with Tiny Datasets Open
Many clinical procedures could benefit from automatic scene segmentation and subsequent action recognition. Using Convolutional Neural Networks to semantically segment meaningful parts of an image or video is still an unsolved problem. Thi…
View article: Tuning the course of evolution on the biophysical fitness landscape of an RNA virus
Tuning the course of evolution on the biophysical fitness landscape of an RNA virus Open
Predicting viral evolution remains a major challenge with profound implications for public health. Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative descripti…
View article: Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures
Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures Open
Topical preexposure prophylaxis (PrEP) against HIV has been marginally successful in recent clinical trials with low adherence rates being a primary factor for failure. Controlled, sustained release of antiretroviral (ARV) drugs may help o…