James Torpy
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View article: Pig carcass decomposition dynamics: Insights into carcass disposal for emergency animal disease management
Pig carcass decomposition dynamics: Insights into carcass disposal for emergency animal disease management Open
Australia is free from many economically devastating emergency animal diseases (EADs) that threaten livestock production in neighbouring countries. In Australia, an important consideration for EAD control is managing susceptible feral anim…
View article: A single-cell and spatially resolved atlas of human breast cancers
A single-cell and spatially resolved atlas of human breast cancers Open
Breast cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. However, our knowledge of their cellular composition and organization is limited. Here we pres…
View article: Quantitative ctDNA Detection in Hepatoblastoma: Implications for Precision Medicine
Quantitative ctDNA Detection in Hepatoblastoma: Implications for Precision Medicine Open
Hepatoblastoma is characterized by driver mutations in CTNNB1, making it an attractive biomarker for a liquid biopsy approach utilizing circulating tumor DNA (ctDNA). This prospective observational study sought to ascertain the feasibility…
View article: A quantitative universal NGS-based ctDNA assay for hepatoblastoma
A quantitative universal NGS-based ctDNA assay for hepatoblastoma Open
Driver mutations in CTNNB1 are a hallmark of hepatoblastoma and offer a common biomarker for a liquid biopsy approach based on the presence of CTNNB1 circulating tumor DNA (ctDNA). We developed and investigated the utility of a quantitativ…
View article: A single-cell and spatially resolved atlas of human breast cancers
A single-cell and spatially resolved atlas of human breast cancers Open
View article: Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance Open
View article: Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer Open
View article: Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer
Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer Open
The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple-negative breast cancers (TNBCs) remains poorly understood, limiting the development of stromal-targeted therapies. Single cell RNA-seque…
View article: Single cell copy number variation profiles reveal diverse heterogeneity in breast tumours
Single cell copy number variation profiles reveal diverse heterogeneity in breast tumours Open
View article: Intergenic disease-associated regions are abundant in novel transcripts
Intergenic disease-associated regions are abundant in novel transcripts Open
View article: Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets Open
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partiall…
View article: Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies Open